Human papillomavirus type 16 E6 and E7 oncogenes abrogate radiation-induced DNA damage responses in vivo through p53-dependent and p53-independent pathways

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

Tumor spectrum analysis in p53-mutant mice

1994 • 2,034 citations

Testing Statistical Hypotheses

1986 • 1,765 citations

Papillomavirus infections — a major cause of human cancers

1996 • 1,536 citations

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

1989 • 1,345 citations

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.

1989 • 1,186 citations

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.

1995 • 1,114 citations

Testing Statistical Hypotheses.

1988 • 996 citations

E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway.

1996 • 904 citations

The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A

1988 • 657 citations

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.

1992 • 617 citations

Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.

1993 • 526 citations

Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

1997 • 506 citations

p53 in growth control and neoplasia

1996 • 488 citations

The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21^Cip1-mediated inhibition of cdk2

1997 • 461 citations

p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.

1994 • 347 citations

Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses.

1992 • 327 citations

Comparison of the in vitro transforming activities of human papillomavirus types.

1988 • 303 citations

Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene

1996 • 264 citations

Destabilization of the RB Tumor Suppressor Protein and Stabilization of p53 Contribute to HPV Type 16 E7-Induced Apoptosis

1997 • 260 citations

Immortalization of human foreskin keratinocytes by various human papillomavirus DNAs corresponds to their association with cervical carcinoma

1989 • 247 citations

Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.

1994 • 243 citations

Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development.

1995 • 234 citations

Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein

1997 • 183 citations

Identification of human papillomavirus type 18 transforming genes in immortalized and primary cells

1989 • 171 citations

Abrogation of growth arrest signals by human papillomavirus type 16 E7 is mediated by sequences required for transformation

1996 • 126 citations

Tumorigenicity by human papillomavirus type 16 E6 and E7 in transgenic mice correlates with alterations in epithelial cell growth and differentiation

1993 • 126 citations

The human papillomavirus-16 E6 oncoprotein decreases the vigilance of mitotic checkpoints

1997 • 121 citations

Cellular transformation by papilomavirus oncorproteins

1993 • 77 citations

Neuroepithelial carcinomas in mice transgenic with human papillomavirus type 16 E6/E7 ORFs.

1993 • 74 citations

Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity

1992 • 72 citations

Mutational Analysis of Human Papillomavirus Type 16 E6 Protein: Transforming Function for Human Cells and Degradation of p53 in Vitro

1995 • 65 citations

Initiation of DNA synthesis by human papillomavirus E7 oncoproteins is resistant to p21-mediated inhibition of cyclin E-cdk2 activity

1997 • 64 citations

Human papillomavirus type 16 E6 gene cooperates with EJ-ras to immortalize primary mouse cells.

1993 • 63 citations

Both conserved region 1 (CR1) and CR2 of the human papillomavirus type 16 E7 oncogene are required for induction of epidermal hyperplasia and tumor formation in transgenic mice

1997 • 59 citations

Perturbation of the p53 response by human papillomavirus type 16 E7

1997 • 44 citations

Nonradioactive RNA in situ hybridization detection of human papillomavirus 16-E7 transcripts in squamous cell carcinomas of the uterine cervix using confocal laser scan microscopy.

1991 • 40 citations

Degradation of p53 only is not sufficient for the growth stimulatory effect of human papillomavirus 16 E6 oncoprotein in human embryonic fibroblasts

1994 • 19 citations

E6 and E7 expression from the HPV 18 LCR: development of genital hyperplasia and neoplasia in transgenic mice.

1995 • 17 citations