Anti-idiotypic antibodies and the induction of specific tumor immunity

Towards a network theory of the immune system.

1974 • 3,379 citations

A New Approach to the Adoptive Immunotherapy of Cancer with Tumor-Infiltrating Lymphocytes

1986 • 1,787 citations

Treatment of B-Cell Lymphoma with Monoclonal Anti-Idiotype Antibody

1982 • 1,001 citations

Search for tumor-specific immune reactions in Burkitt lymphoma patients by the membrane immunofluorescence reaction.

1966 • 312 citations

Implications of the presence of an internal image of the antigen in anti-idiotypic antibodies: Possible application to vaccine production

1981 • 296 citations

Neonatal administration of idiotype or antiidiotype primes for protection against Escherichia coli K13 infection in mice.

1984 • 265 citations

Localization of 131I-labeled p97-specific Fab fragments in human melanoma as a basis for radiotherapy.

1983 • 264 citations

Genetics, Expression, and Function of Idiotypes

1983 • 264 citations

Emergence of Idiotype Variants during Treatment of B-Cell Lymphoma with Anti-Idiotype Antibodies

1985 • 257 citations

Human anti-idiotype antibodies in cancer patients: Is the modulation of the immune response beneficial for the patient?

1984 • 247 citations

Cell surface antigens of human malignant melanoma. II. Serological typing with immune adherence assays and definition of two new surface antigens.

1976 • 238 citations

Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.

1986 • 232 citations

Idiotypic-anti-idiotypic regulation of antibody synthesis in rabbits.

1977 • 219 citations

Structural characterization of human melanoma-associated antigen p97 with monoclonal antibodies.

1981 • 203 citations

Idiotype-anti-idiotype regulation. I. Immunization with a levan-binding myeloma protein leads to the appearance of auto-anti-(anti-idiotype) antibodies and to the activation of silent clones.

1981 • 190 citations

Immunization of mice against African trypanosomiasis using anti-idiotypic antibodies.

1982 • 188 citations

STUDIES OF IDIOTYPIC ANTIBODIES

1974 • 160 citations

Syngeneic monoclonal antiidiotype can induce cellular immunity to reovirus.

1984 • 144 citations

Induction of neutralizing antibody in mice against poliovirus type II with monoclonal anti-idiotypic antibody.

1985 • 128 citations

Anti-Idiotypic Antibodies Bear the Internal Image of a Human Tumor Antigen

1986 • 126 citations

Mechanisms of regulation of cell-mediated immunity. IV. Azobenzenearsonate-specific suppressor factor(s) bear cross-reactive idiotypic determinants the expression of which is linked to the heavy-chain allotype linkage group of genes.

1979 • 121 citations

Counteraction of the blocking of cell‐mediated tumor immunity by inoculation of unblocking sera and splenectomy: immunotherapeutic effects on primary polyoma tumors in rats

1972 • 115 citations

Control of Idiotope Expression by Monoclonal Anti-Idiotope Antibodies

1980 • 112 citations

Anti-immunoglobulin antibodies. III. Properties of sequential anti-idiotypic antibodies to heterologous anti-gamma globulins. Detection of reactivity of anti-idiotype antibodies with epitopes of Fc fragments (homobodies) and with epitopes and idiotopes (epibodies).

1982 • 104 citations

“Unblocking” Serum Activity in vitro in the Polyoma System may Correlate with Antitumour Effects of Antiserum in vivo

1971 • 89 citations

Regulation of Immunity to the Azobenzenearsonate Hapten

1982 • 89 citations

Spontaneous Alteration of Idiotype in a Monoclonal B-Cell Lymphoma

1985 • 81 citations

Specific blocking factors — are they important?

1977 • 80 citations

Reciprocal expansions of idiotypic and anti-idiotypic clones following antigen stimulation

1979 • 77 citations

Suppression of in vivo tumor formation induced by simian virus 40-transformed cells in mice receiving antiidiotypic antibodies.

1985 • 75 citations

Idiotypes, recurrent idiotypes and internal images.

1982 • 74 citations

Suppression of tumor rejection by autologous anti-idiotypic immunity

1980 • 68 citations

Specific detection of anti-idiotypic immune responses in cancer patients treated with murine monoclonal antibody

1985 • 66 citations

Induction of anti-tobacco mosaic virus antibodies in mice by rabbit antiidiotypic antibodies.

1984 • 65 citations

Induction of immunity to a human tumor marker by in vivo administration of anti-idiotypic antibodies in mice.

1984 • 64 citations

Definition of T cell idiotypes using anti-idiotypic antisera produced by immunization with T cell clones.

1982 • 63 citations

Monoclonal antiidiotypic antibodies related to a murine oncofetal bladder tumor antigen induce specific cell-mediated tumor immunity.

1985 • 55 citations

Reduced tumor growth after low-dose irradiation or immunization against blastic suppressor T cells.

1981 • 52 citations

Immunization to a syngeneic sarcoma by a monoclonal auto-anti-idiotypic antibody

1983 • 51 citations

Immunotherapy of murine sarcomas with auto-anti-idiotypic monoclonal antibodies which bind to tumor-specific T cells.

1987 • 46 citations

Identification of idiotypic receptors on reovirus-specific cytolytic T cells.

1982 • 46 citations

Suppressor mechanisms in tumor immunity

1983 • 28 citations

Antigen-specific purification of blocking factors from sera of mice with chemically induced tumors.

1977 • 27 citations

Induction or elimination of tumor‐specific immunity against a chemically‐induced rat tumor using auto‐anti‐idiotypic immunity

1982 • 24 citations

Internal images of antigens within the immune network

1983 • 23 citations

Enhancement of viral hepatitis B antibody (anti-HBs) response to a synthetic cyclic peptide by priming with anti-idiotype antibodies

1984 • 20 citations

Idiotypic interactions in immune responses to tumor-associated antigens

1986 • 15 citations

Poly(Glu⁶⁰, Ala³⁰, Tyr¹⁰) (GAT)‐specific T cells do not express B cell public idiotopes but can be primed by monoclonal anti‐idiotypic antibodies

1984 • 15 citations

Inhibition of in vivo growth of murine plasmacytoma MOPC-460 by monoclonal anti-idiotypic antibodies directed at distinct idiotypes of the immunoglobulin on the surface of MOPC-460.

1984 • 13 citations

Monoclonal antibodies coupled to LPS specifically induce synthesis of immunoglobulins with complementary variable region determinants.

1982 • 13 citations

T cell development in B cell-deficient mice. V. Stopping anti-mu treatment results in Igh-restricted expansion of the T suppressor cell repertoire concomitant with the development of normal immunoglobulin levels.

1986 • 12 citations

The influence of B-cell idiotypes on the repertoire of suppressor T cells

1986 • 12 citations

Tumor-specific idiotopes on suppressor factors and suppressor cells revealed by monoclonal anti-idiotope antibodies

1987 • 11 citations

Induction of suppressor T cells by monoclonal anti-idiotope antibody in strains of mice not expressing the idiotope in hyperimmune serum.

1983 • 10 citations

The expression and functional involvement of nuclease‐specific idiotype on nuclease‐primed helper T cells

1982 • 9 citations

Antibodies to murine leukemia virus gp70 and p15(E) in sera of BALB/c mice immunized with syngeneic chemically induced sarcomas.

1980 • 8 citations

Idiotype-specific T lymphocytes. II. capability of generation of idiotype-specific T lymphocytes is determined by corresponding VH gene.

1983 • 4 citations

Idiotype Regulation in the Antibody Response to Phosphocholine

1984 • 3 citations

Induction of Anti-Viral Immunity by an Anti-Idiotypic Antibody Directed to a Sendai Virus Specific T Helper Cell Clone

1986 • 3 citations