Suppressor mechanisms in tumor immunity

Towards a network theory of the immune system.

1974 • 3,379 citations

Immunity to Methylcholanthrene-Induced Sarcomas

1957 • 1,241 citations

Suggestive Evidence That the “Blocking Antibodies” of Tumor-Bearing Individuals May Be Antigen-Antibody Complexes

1971 • 691 citations

T Cell Control of Antibody Production

1974 • 582 citations

Suppressor T Lymphocytes Control the Development of Primary Skin Cancers in Ultraviolet-Irradiated Mice

1982 • 395 citations

Immunological enhancement of tumor homografts in mice: a review.

1958 • 346 citations

Immunologic Mechanisms in UV Radiation Carcinogenesis

1981 • 295 citations

Blocking of Lymphocyte-mediated Cytotoxicity for Rat Hepatoma Cells by Tumour-specific Antigen-Antibody Complexes

1972 • 295 citations

Serum Mediated Inhibition of the Immunological Reactions of the Patient to his Own Tumour: A Possible Role for Circulating Antigen

1972 • 289 citations

Foetal “Antigens” in Cancer

1972 • 268 citations

SERUM-MEDIATED PROTECTION OF NEOPLASTIC CELLS FROM INHIBITION BY LYMPHOCYTES IMMUNE TO THEIR TUMOR-SPECIFIC ANTIGENS

1969 • 264 citations

The Role of Antigen-Specific T Cell Factors in the Immune Response

1980 • 250 citations

Regulation of the immune response to tumor antigens. II. The nature of immunosuppressor cells in tumor-bearing hosts.

1976 • 239 citations

The Nature of Immune Complexes in Human Cancer Sera

1977 • 204 citations

Immunological circuits: cellular composition.

1979 • 200 citations

Antigen- and receptor-driven regulatory mechanisms. IV. Idiotype-bearing I-J+ suppressor T cell factors induce second-order suppressor T cells which express anti-idiotypic receptors.

1980 • 166 citations

Suppressor Cells: Permitters and Promoters of Malignancy?

1979 • 162 citations

Inhibition of hepatoma‐immune lymph‐node cell cytotoxicity by tumour‐bearer serum, and solubilized hepatoma antigen

1973 • 157 citations

Ex vivo removal of serum igg in a patient with colon carcinoma.Some biochemical, immunological and histological observations

1978 • 141 citations

Properties of Primed Suppressor T Cells and their Products

1975 • 140 citations

Active suppression of 1-fluoro-2,4-dinitrobenzene-immune T cells. Requirement of an auxiliary T cell induced by antigen.

1979 • 126 citations

Immunological Facilitation, a Broadening of the Concept of the Enhancement Phenomenon

2015 • 124 citations

Reduction of syngeneic tumor growth by an anti-I-J-alloantiserum.

1977 • 120 citations

In Vitro Induction of Cytotoxicity against Syngeneic Mastocytoma and Its Suppression by Spleen and Thymus Cells from Tumor-Bearing Mice

1976 • 118 citations

Regression and inhibition of sarcoma growth by interference with a radiosensitive T-cell population.

1978 • 118 citations

Helper and suppressor T cell factors

1980 • 117 citations

Activation of suppressor T cells by tumour cells and specific antibody

1974 • 117 citations

Regulation of the Immune Response to Tumor Antigens

1976 • 114 citations

Effect on Tumour Growth in Syngeneic Recipients of Antibodies Against Tumour-Specific Antigens in Methylcholanthrene-Induced Mouse Sarcomas

1964 • 104 citations

Extensive necrosis of spontaneous canine mammary adenocarcinoma after extracorporeal perfusion over Staphylococcus aureus Cowans I. I. Description of acute tumoricidal response: morphologic, histologic, immunohistochemical, immunologic, and serologic findings.

1980 • 102 citations

IMMUNOLOGICAL ENHANCEMENT OF TUMOR GROWTH BY SYNGENEIC THYMUS-DERIVED LYMPHOCYTES

1974 • 98 citations

SUPPRESSOR T CELLS IN CELL-MEDIATED IMMUNITY

1976 • 93 citations

Regulation of immune responses by suppressor T cells.

1976 • 91 citations

Regulation of the immune response to tumor antigens. III. Characterization of thymic suppressor factor(s) produced by tumor-bearing hosts.

1977 • 89 citations

Cellular interaction between cytotoxic and suppressor T cells against syngeneic tumors in the mouse

1978 • 86 citations

The locus coeruleus: actions of psychoactive drugs

1983 • 80 citations

Specific blocking factors — are they important?

1977 • 80 citations

Circulating immune complexes in sera of patients with Burkitt's lymphoma and nasopharyngeal carcinoma

1976 • 76 citations

Immunological Facilitation, a Broadening of the Concept of the Enhancement Phenomenon (Part 1 of 3)

1971 • 74 citations

Treatment of feline leukemia and reversal of FeLV byex vivo removal of IgG: A preliminary report

1980 • 69 citations

Antigen-specific T-cell-mediated suppression. I. Induction of L-glutamic acid(60)-L-alanine(30)-L-tyrosine(10) specific suppressor T cells in vitro requires both antigen-specific T-cell-suppressor factor and antigen

1978 • 68 citations

Effects of blocking helper T cell induction in vivo with anti-Ia antibodies. Possible role of I-A/E hybrid molecules as restriction elements.

1980 • 68 citations

Suppression of tumor rejection by autologous anti-idiotypic immunity

1980 • 68 citations

Tolerance and contact sensitivity to DNFB in mice. VI. Inhibition of afferent sensitivity by suppressor T cells in adoptive tolerance.

1976 • 64 citations

In vivo effects of antibodies to immune response gene products. I. Haplotype-specific suppression of humoral immune responses with a monoclonal anti-I-A.

1981 • 60 citations

Cellular consequences in the suppression of antibody response by the antigen-specific T-cell factor.

1980 • 56 citations

Correlation between immune complexes and prognostic factors in Hodgkin's disease.

1978 • 55 citations

Evidence that tumor antigens enhance tumor growth in vivo by interacting with a radiosensitive (suppressor?) cell population.

1978 • 54 citations

Reduced tumor growth after low-dose irradiation or immunization against blastic suppressor T cells.

1981 • 52 citations

The Genetic and Cellular Basis of Regulation of the Immune Response to Tumor Antigens

1980 • 49 citations

Regulation of the Immune Response to Tumor Antigens

1977 • 47 citations

Specific desensitization of resistance against a syngeneic methylcholanthrene-induced sarcoma in C3Hf mice.

1972 • 47 citations

Antigen-antibody complexes generate Lyt 1 inducers of suppressor cells.

1980 • 41 citations

Loss of Ia-bearing splenic adherent cells after whole body ultraviolet irradiation.

1980 • 40 citations

Circulating immune complexes in sera of children with neuroblastoma: correlation with stage of disease.

1978 • 40 citations

Regulation of the Immune Response to Tumor Antigen

1978 • 39 citations

Genetic control of the immune response to myoglobins. IV. Inhibition of determinant-specific Ir gene-controlled antigen presentation and induction of suppression by pretreatment of presenting cells with anti-Ia antibodies.

1981 • 39 citations

Regulation of the immune response to tumor antigen. VI. Differential specificities of suppressor T cells or their products and effector T cells.

1978 • 37 citations

Immune Complexes in Cancer: Demonstration of Complexes in Mice Bearing Neuroblastomas2

1975 • 34 citations

Regression of polyoma tumor metastasis by combined unblocking and bcg treatment‐correlation with induced alterations in tumor immunity status

1973 • 34 citations

Regulation of immune response to tumor antigen: interference with syngeneic tumor immunity by anti-IA alloantisera.

1979 • 33 citations

Sequential quantitation of circulating immune complexes in syngeneic and allogeneic rats bearing Moloney sarcomas.

1977 • 32 citations

Tumor-enhancing suppressor activator T cells in spleens and thymuses of tumor immune mice.

1979 • 32 citations

Immunity to murine sarcoma virus induced tumours. IV. Direct cellular cytolysis of 51Cr labelled target cells in vitro and analysis of blocking factors which modulate cytotoxicity

1975 • 30 citations

Proceedings: Implications of the fetal antigen theory for fetal transplantation.

1974 • 30 citations

Specific anti‐tumor responses of cultured immune spleen cells III. Further characterization of cells which synthesize factors with blocking and antiserum‐dependent cellular cytotoxic (ADC) activities

1975 • 30 citations

Specific anti‐tumor responses by cultured immune spleen cells. I. In vitro culture method and initial characterization of factors which block immune cell‐mediated cytotoxicity in vitro

1975 • 30 citations

Antigen-specific suppressor T cell interactions. I. Induction of an MHC-restricted suppressor factor specific for L-glutamic acid50-L-tyrosine50.

1982 • 29 citations

Antigen-specific purification of blocking factors from sera of mice with chemically induced tumors.

1977 • 27 citations

Tolerance and Contact Sensitivity to DNFB in Mice

1976 • 27 citations

Proceedings: Proposed mechanisms by which autochthonous neoplasms escape immune rejection.

1974 • 26 citations

Purification and Partial Characterization of a Tumor-Specific Blocking Factor from Sera of Mice with Growing Chemically Induced Sarcomas

1976 • 25 citations

T cell subset interactions in the regulation of syngeneic tumor immunity.

1981 • 24 citations

Regulation of the immune response to tumor antigen

1980 • 23 citations

Suppression of Cytotoxic Lymphocyte Responses in Vitro by Soluble Products of Alloantigen-Activated Spleen Cells

1978 • 23 citations

Sequential Quantitation of Circulating Immune Complexes in Syngeneic and Allogeneic Rats Bearing Moloney Sarcomas

1977 • 21 citations

In vitro synthesis of tumor‐specific factors with blocking and antibody‐dependent cellular cytotoxicity (ADC) activities

1975 • 20 citations

The genetic and cellular basis of antigen and receptor stimulated regulation

1980 • 20 citations

The physiological regulation of immunity: Differential regulatory contributions of peripheral and central lymphon compartments

1979 • 19 citations

Production of T‐cell lines with inhibitory or stimulatory activity against syngeneic tumors in vivo. A preliminary report

1981 • 17 citations

Human Blood T Lymphocytes That Suppress the Mixed Leukocyte Culture Reactivity of Lymphocytes from HLA-B14 Bearing Individuals

1979 • 17 citations

T-T hybridoma product specifically suppresses tumor immunity.

1980 • 17 citations

Regulation of Cell-Mediated Immunologic Reactivity to Moloney Murine Sarcoma Virus-Induced Tumors. II. Nature of Blocking and Unblocking Factors in Serum2, 3

1981 • 16 citations

T–T cell collaboration in rejection of a syngeneic SV40-induced sarcoma in mice

1978 • 14 citations

Cell‐mediated suppression of tumor immunity has a non‐specific component. I. Evidence from transplantation tests

1981 • 10 citations

DISCUSSION PAPER: SPECIFIC PARALYSIS OF THE ANTITUMOR CELLULAR IMMUNE RESPONSE PRODUCED BY GROWING TUMORS STUDIED WITH A RADIOISOTOPE FOOTPAD ASSAY

1976 • 7 citations

Suppressor pathways in tumor immunity: A requirement for Qa‐1 positive tumor‐bearer spleen t cells in suppression of the afferent immune response to tumor antigens

1981 • 6 citations

Studies on the Mechanisms of Tumor Immunity: Some Recent Data on Cellular Immunity to Common, Possibly Embryonic Antigens in Mouse Sarcomas

1975 • 6 citations

Hapten-coupled monoclonal anti-I-A antibodies provide a first signal for the induction of suppression.

1982 • 5 citations

Deleted Work

1955 • 0 citations