Specific blocking factors — are they important?

Lymphocyte-Mediated Cytotoxicity And Blocking Serum Activity To Tumor Antigens

1974 • 651 citations

Immunology of Experimental Tumors

1964 • 487 citations

Cellular Immunity Against Tumor Antigens

1969 • 474 citations

Blocking of cell‐mediated tumor immunity by sera from patients with growing neoplasms

1971 • 423 citations

Immunological enhancement of tumor homografts in mice: a review.

1958 • 346 citations

Regualtion of the immune response to tumor antigens. I. Immunosuppressor cells in tumor-bearing hosts.

1976 • 339 citations

Immunological Enhancement as Studied by Cell Culture Techniques

1970 • 325 citations

Studies on cellular immunity and its serum‐mediated inhibition in moloney‐virus‐induced mouse sarcomas

1969 • 316 citations

Blocking of Lymphocyte-mediated Cytotoxicity for Rat Hepatoma Cells by Tumour-specific Antigen-Antibody Complexes

1972 • 295 citations

Serum Mediated Inhibition of the Immunological Reactions of the Patient to his Own Tumour: A Possible Role for Circulating Antigen

1972 • 289 citations

Foetal “Antigens” in Cancer

1972 • 268 citations

Regulation of the immune response to tumor antigens. II. The nature of immunosuppressor cells in tumor-bearing hosts.

1976 • 239 citations

Immunological Aspects Of Chemical Carcinogenesis

1973 • 225 citations

THE ROLE OF PRODUCTS OF THE HISTOCOMPATIBILITY GENE COMPLEX IN IMMUNE RESPONSES

1975 • 223 citations

Colony inhibition studies on blocking and non‐blocking serum effects on cellular immunity to moloney sarcomas

1970 • 197 citations

Carcinoembryonic Antigen-Antibody Complexes in a Patient with Colonic Carcinoma and Nephrotic Syndrome

1973 • 195 citations

Elution of “blocking factors” from human tumors, capable of abrogating tumor‐cell destruction by specifically immune lymphocytes

1972 • 190 citations

Serum mediated inhibition of cellular immunity to methylcholanthrene-induced murine sarcomas

1970 • 180 citations

IMMUNOLOGICAL STUDIES IN NEPHROTIC SYNDROME ASSOCIATED WITH EXTRARENAL MALIGNANT DISEASE

1971 • 170 citations

Inhibition of hepatoma‐immune lymph‐node cell cytotoxicity by tumour‐bearer serum, and solubilized hepatoma antigen

1973 • 157 citations

Sequential studies on cell‐mediated tumor immunity and blocking serum activity in ten patients with malignant melanoma

1973 • 148 citations

Evidence for an Immunological Reaction of the Host Directed Against Its Own Actively Growing Primary Tumor<xref ref-type="fn" rid="FN1">2</xref>

1966 • 148 citations

Immunity to murine sarcoma virus-inducted tumors. II. Suppression of T cell-mediated immunity by cells from progressor animals.

1974 • 134 citations

In vitro studies of immune reactions against autochthonous and syngeneic mouse tumors induced by methylcholanthrene and plastic discs

1968 • 127 citations

Circulating immune complexes in human neuroblastoma: Direct assay and role in blocking specific cellular immunity

1974 • 126 citations

In vitro methods in cell-mediated immunity

1970 • 125 citations

On Concomitant Immunity in Tumour-bearing Hamsters

1967 • 120 citations

Immunological Enhancement: A Study of Blocking Antibodies

1972 • 120 citations

Problems Associated With Study of Cell-Mediated Immunity to Human Tumors by Microcytotoxicity Assays

1975 • 119 citations

In Vitro Induction of Cytotoxicity against Syngeneic Mastocytoma and Its Suppression by Spleen and Thymus Cells from Tumor-Bearing Mice

1976 • 118 citations

Activation of suppressor T cells by tumour cells and specific antibody

1974 • 117 citations

Cross-reacting tumor-associated antigen (s) among chemically induced rat colon carcinomas.

1974 • 115 citations

Counteraction of the blocking of cell‐mediated tumor immunity by inoculation of unblocking sera and splenectomy: immunotherapeutic effects on primary polyoma tumors in rats

1972 • 115 citations

Cellular immunity and its serum‐mediated inhibition in shope‐virus‐induced rabbit papillomas

1969 • 105 citations

Effect on Tumour Growth in Syngeneic Recipients of Antibodies Against Tumour-Specific Antigens in Methylcholanthrene-Induced Mouse Sarcomas

1964 • 104 citations

Evolution of Cell-Mediated Immunity in Mice Bearing an Antigenic Tumor. Influence of Tumor Growth and Surgical Removal

1969 • 101 citations

Facilitation of polyoma tumor growth in rats by blocking sera and tumor eluate

1972 • 100 citations

The effect of tumor size on concomitant tumor immunity.

1973 • 93 citations

Immunological tolerance mechanisms and potential therapeutic applications

1975 • 91 citations

The Presence of Tumour Specific Membrane Antigen in the Serum of Rats with Chemically Induced Sarcomata

1973 • 89 citations

“Unblocking” Serum Activity in vitro in the Polyoma System may Correlate with Antitumour Effects of Antiserum in vivo

1971 • 89 citations

Neoantigens on spontaneous and carcinogen‐induced rat tumours defined by in vitro lymphocytotoxicity assays

1974 • 87 citations

Evolution of cell‐mediated antitumor immunity in mice bearing a syngeneic chemically induced tumor. Influence of tumor growth, surgical removal and treatment with irradiated tumor cells

1972 • 86 citations

Studies on serum‐mediated inhibition of cellular immunity to spontaneous mouse mammary tumors

1969 • 85 citations

Detection of Circulating Hepatoma D23 Antigen and Immune Complexes in Tumour Bearer Serum

1973 • 77 citations

Circulating immune complexes in sera of patients with Burkitt's lymphoma and nasopharyngeal carcinoma

1976 • 76 citations

Leukocyte adherence inhibition and specific immunoreactivity in malignant melanoma

1975 • 75 citations

Requiem for the Nature Conservancy

1972 • 70 citations

Inhibition of in vitro lymphoproliferative responses to tumor‐associated antigens by suppressor cells from rats bearing progressively growing gross leukemia virus‐induced tumors

1975 • 69 citations

Influence of tumor antigen on maintenance versus depression of tumor-specific immunity.

1973 • 67 citations

Immunoglobulin complexes in sera of patients with malignancy

1977 • 66 citations

Nonspecific and specific immuno-suppression in tumour-bearing mice by soluble immune complexes

1975 • 64 citations

Evidence for Cancer-specific Antigens in Man

2015 • 64 citations

Tumor-associated immunoglobulins. enhancement of syngeneic tumors by igg2-containing tumor eluates

1972 • 62 citations

Defects in cell‐mediated immunity during growth of a syngeneic simian virus‐induced tumor

1975 • 62 citations

Tumor-specific immunity in the course of primary polyoma and Rous tumor development in intact and immunosuppressed rats.

1971 • 61 citations

LYMPHOCYTE-MEDIATED CYTOTOXICITY IN VITRO

1971 • 60 citations

Radioimmunoassay of Tumour Specific Transplantation Antigen of a Chemically Induced Rat Sarcoma: Circulating Soluble Tumour Antigen in Tumour Bearers

1973 • 57 citations

Serum-Mediated Inhibition of Lymphocyte Stimulation by Autochthonous Human Tumors<xref ref-type="fn" rid="FN2">2</xref>

1971 • 56 citations

Tumor-Associated Blocking Factors: Isolation from Sera of Tumor-Bearing Mice

1976 • 56 citations

Blocking and unblocking of cell-mediated anti-tumor immunity in mice, as detected by the leucocyte adherence inhibition test

1974 • 55 citations

Macrophage migration inhibition with mouse tumor antigens: Properties of serum and peritoneal cells during tumor growth and after tumor loss

1972 • 53 citations

Cell-mediated immune reactions to tumor antigens with particular emphasis on immunity to human neoplasms

1974 • 51 citations

A Factor Preventing the Development of Lung Metastases in Rats with Sarcomas

1973 • 51 citations

Blocking of syngeneic effector T cells by soluble tumour antigens

1974 • 49 citations

IN VITRO ACTIVATION OF CELLULAR IMMUNE RESPONSE TO GROSS VIRUS-INDUCED LYMPHOMA

1972 • 48 citations

Circulating Antigen-Antibody Complex Associated With Epstein-Barr Virus in Recurrent Burkitt's Lymphoma2

1973 • 47 citations

Specific desensitization of resistance against a syngeneic methylcholanthrene-induced sarcoma in C3Hf mice.

1972 • 47 citations

Specific “arming” of normal lymph‐node cells by sera from tumor‐bearing mice

1973 • 45 citations

ANTIBODIES AND ANTI-ANTIBODIES IN HUMAN MALIGNANCY: AN EXPRESSION OF DERANGED IMMUNE REGULATION

1976 • 45 citations

Cell-mediated destruction of rous sarcomas in Japanese quails

1972 • 41 citations

Immune complex disease associated with spontaneous murine leukemia: Incidence and pathogenesis of glomerulonephritis

1972 • 41 citations

Inhibition of Tumor-Induced Lymphocyte Blastogenesis by a Factor or Factors Associated with Peripheral Leukocytes

1974 • 40 citations

Evidence that blocking factors in the sera of multiparous mice are associated with immunoglobulins

1975 • 40 citations

Suppression by Serum-Blocking Cytosine Arabinoside of Factors of Cell-Mediated Immunity to Syngeneic Transplants of Mouse Mammary Tumors<xref ref-type="fn" rid="FN1">1</xref><xref ref-type="fn" rid="FN2">2</xref>

1972 • 36 citations

RENAL DEPOSITION OF SOLUBLE IMMUNE COMPLEXES IN MICE BEARING B-16 MELANOMA

1974 • 36 citations

Immune Complexes in Cancer: Demonstration of Complexes in Mice Bearing Neuroblastomas2

1975 • 34 citations

Regression of polyoma tumor metastasis by combined unblocking and bcg treatment‐correlation with induced alterations in tumor immunity status

1973 • 34 citations

Reversal of Tumor-Mediated Suppression of Immune Reactivity by in Vitro Incubation of Spleen Cells

1974 • 32 citations

Immunity to murine sarcoma virus induced tumours. IV. Direct cellular cytolysis of 51Cr labelled target cells in vitro and analysis of blocking factors which modulate cytotoxicity

1975 • 30 citations

Specific anti‐tumor responses of cultured immune spleen cells III. Further characterization of cells which synthesize factors with blocking and antiserum‐dependent cellular cytotoxic (ADC) activities

1975 • 30 citations

Specific anti‐tumor responses by cultured immune spleen cells. I. In vitro culture method and initial characterization of factors which block immune cell‐mediated cytotoxicity in vitro

1975 • 30 citations

Serum effects on cell‐mediated destruction of rous sarcomas

1973 • 29 citations

Analysis of inhibition of lymphocyte cytotoxicity in human colon carcinoma

1975 • 28 citations

Serum inhibitors of cellular immunity in human neuroblastoma. IgG subclass of blocking activity

1974 • 28 citations

Further studies on the ability of regressor sera to block cell‐mediated destruction of rous sarcomas

1974 • 27 citations

Concomitant immunity in hamsters bearing syngeneic transplants of tumors induced by para‐adenovirus 7, simian adenovirus 7, or 9,10‐dimethylbenzanthracene

1971 • 27 citations

Enhanced growth of primary moloney virus‐induced sarcomas in mice

1971 • 26 citations

Cytotoxic effect of lymphocytes from pregnant mice on cultivated tumor cells. II. Blocking and unblocking of cytotoxicity

1975 • 25 citations

Purification and Partial Characterization of a Tumor-Specific Blocking Factor from Sera of Mice with Growing Chemically Induced Sarcomas

1976 • 25 citations

Tumour‐specific antibody neutralization of factors in rat hepatoma‐bearer serum which abrogate lymph‐node‐cell cytotoxicity

1974 • 24 citations

CELLULAR AND HUMORAL IMMUNITY AFTER ALLOGENEIC TRANSPLANTATION IN THE RAT II. COMPARISON OF A 51Cr RELEASE ASSAY AND MODIFIED MICROCYTOTOXICITY ASSAY FOR DETECTION OF CELLULAR IMMUNITY AND BLOCKING SERUM FACTORS

1973 • 23 citations

In vitro synthesis of tumor‐specific factors with blocking and antibody‐dependent cellular cytotoxicity (ADC) activities

1975 • 20 citations

In vitro activity of lymphocytes and serum of C3Hf-Bu mice during the growth of methylcholanthrene-induced tumor and its regression following local irradiation.

1974 • 18 citations

IMMUNOBIOLOGY OF RAT NEOPLASIA*

1976 • 17 citations

IN VIVO EFFECTS OF LYMPHOCYTES SENSITIZED IN VITRO AGAINST TUMOR CELLS*

1976 • 16 citations

Restoration of specific immunity against SV40 tumor‐specific transplantation antigen to lymphoid cells from tumor‐bearing mice

1975 • 15 citations

The effects of cyclophosphamide onin vitro correlates of tumor immunity

1974 • 14 citations

CELL‐MEDIATED IMMUNITY TO MOUSE TUMORS: SOME RECENT FINDINGS*

1976 • 14 citations

Specific depression of the antitumor cellular immune response with autologous tumor homogenate.

1975 • 13 citations

Abrogation of Passively Transferred Tumor Immunity &lt;italic&gt;In Vivo&lt;/italic&gt; by Antigenically Related Tumor Cells

1971 • 13 citations

Immunoglobulin on Tumor Cells and Tumor-Induced Lymphocyte Blastogenesis in Human Acute Leukemia

1973 • 12 citations

Reversal of SV40 Tumor-Mediated Suppression of Spleen Cell Cytotoxicity by Antibody

1977 • 11 citations

Specific anti‐tumor responses by cultured immune spleen cells. II. Culture supernatants induce specific anti‐tumor cytotoxicity by non‐immune lymphoid cells in vitro

1975 • 10 citations

Complexity of Factors in Sera of Different Mice That Affect MTV-Induced Mammary Tumor Cells

1976 • 10 citations

DISCUSSION PAPER: SPECIFIC PARALYSIS OF THE ANTITUMOR CELLULAR IMMUNE RESPONSE PRODUCED BY GROWING TUMORS STUDIED WITH A RADIOISOTOPE FOOTPAD ASSAY

1976 • 7 citations