Internal images of antigens within the immune network

Towards a network theory of the immune system.

1974 • 3,379 citations

The somatic generation of immune recognition

1971 • 974 citations

Individual Antigenic Specificity of Isolated Antibodies

1963 • 494 citations

Induction of T and B cell immunity by anti‐idiotypic antibody

1975 • 448 citations

Croonian lecture.—On immunity with special reference to cell life

1900 • 427 citations

Recurrent idiotopes and internal images.

1982 • 424 citations

Use of anti-idiotypic antibodies as cell-surface receptor probes

1978 • 345 citations

Implications of the presence of an internal image of the antigen in anti-idiotypic antibodies: Possible application to vaccine production

1981 • 296 citations

Idiotype-anti-idiotype regulation. I. Immunization with a levan-binding myeloma protein leads to the appearance of auto-anti-(anti-idiotype) antibodies and to the activation of silent clones.

1981 • 190 citations

Anti-alprenolol anti-idiotypic antibodies bind to beta-adrenergic receptors and modulate catecholamine-sensitive adenylate cyclase.

1980 • 173 citations

Idiotypes as Variable Region Markers Analogies between Receptors on Phosphorylcholine-Specific T and B Lymphocytes

1977 • 170 citations

Identification of a hemagglutinin-specific idiotype associated with reovirus recognition shared by lymphoid and neural cells.

1982 • 127 citations

Anti-immunoglobulin antibodies. III. Properties of sequential anti-idiotypic antibodies to heterologous anti-gamma globulins. Detection of reactivity of anti-idiotype antibodies with epitopes of Fc fragments (homobodies) and with epitopes and idiotopes (epibodies).

1982 • 104 citations

QUANTITATIVE ABSOLUTE METHODS IN THE STUDY OF ANTIGEN-ANTIBODY REACTIONS

1939 • 91 citations

Idiotypic regulation of the immune system. Common idiotypic specificities between idiotypes and antibodies raised against anti-idiotypic antibodies in rabbits.

1979 • 88 citations

Vaccinia-specific cytotoxic T-cell responses in the context of H-2 antigens not encountered in thymus may reflect aberrant recognition of a virus-H-2 complex.

1979 • 80 citations

Immunological studies of T-cell receptors. II. Limited polymorphism of idiotypic determinants on T-cell receptors specific for major histocompatibility complex alloantigens.

1979 • 54 citations

Absence of Ir gene control of T cells recognizing foreign antigen in the context of allogeneic MHC molecules

1982 • 51 citations

Anti-idiotypic antibodies against anti-vitamin A transporting protein react with prealbumin

1978 • 50 citations

Idiotypic determinants on T-cell subpopulations.

1979 • 45 citations

Shared idiotypes among monoclonal antibodies specific for different immunodominant sugars of lipopolysaccharide of different Gram-negative bacteria.

1982 • 44 citations

Homobodies: do they exist?

1979 • 32 citations

Self H-2 antigens influence the specificity of alloreactive cells.

1980 • 30 citations

Mixed Lymphocyte Interaction: Disquisitions on a Popular Unknown

1971 • 9 citations

The Appearance of 460-Idiotype (460-Id)-Bearing Anti-TNP Antibodies Is Regulated by Suppressor T Cells Specific for 460-Id

1980 • 4 citations