Idiotype Regulation in the Antibody Response to Phosphocholine

Towards a network theory of the immune system.

1974 • 3,379 citations

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region

1981 • 677 citations

A single VH gene segment encodes the immune response to phosphorylcholine: Somatic mutation is correlated with the class of the antibody

1981 • 470 citations

Immunoregulatory circuits among T-cell sets. I. T-helper cells induce other T-cell sets to exert feedback inhibition.

1978 • 424 citations

An Analysis of the Murine NK Cell as to Structure, Function and Biological Relevance

1979 • 351 citations

Expression and Function of Idiotypes on Lymphocytes

1978 • 340 citations

Two distinct types of helper T cells involved in the secondary antibody response: independent and synergistic effects of Ia- and Ia+ helper T cells.

1978 • 316 citations

Anti-phosphorylcholine antibodies of the T15 idiotype are optimally protective against Streptococcus pneumoniae.

1982 • 303 citations

Evidence for the clonal abortion theory of B-lymphocyte tolerance.

1975 • 293 citations

Idiotype‐specific T helper cells are required to induce idiotype‐positive B memory cells to secrete antibody

1978 • 268 citations

Subclass restriction of murine antibodies. II. The IgG plaque-forming cell response to thymus-independent type 1 and type 2 antigens in normal mice and mice expressing an X-linked immunodeficiency.

1980 • 258 citations

Specific Suppression of the Antibody Response by Antibodies to Receptors

1972 • 254 citations

Idiotype suppression. I. Influence of the dose and of the effector functions of anti‐idiotypic antibody on the production of an idiotype

1974 • 249 citations

Idiotypic-anti-idiotypic regulation of antibody synthesis in rabbits.

1977 • 219 citations

B-lymphocyte heterogeneity: development and characterization of an alloantiserum which distinguishes B-lymphocyte differentiation alloantigens.

1977 • 212 citations

Idiotypic regulation of the immune system by the induction of antibodies against anti-idiotypic antibodies.

1977 • 211 citations

Specific Inhibition of Plaque Formation to Phosphorylcholine by Antibody against Antibody

1972 • 200 citations

Specificity for phosphorylchloine of six murine myeloma proteins reactive with Pneumococcus C polysaccharide and β-lipoprotein

1971 • 179 citations

The Ontogeny of Thymic Independent Antibody Responses in Vitro in Normal Mice and Mice with an X-Linked B Cell Defect

1977 • 171 citations

Mouse IgG3 antibodies are highly protective against infection with Streptococcus pneumoniae

1981 • 170 citations

Idiotypes as Variable Region Markers Analogies between Receptors on Phosphorylcholine-Specific T and B Lymphocytes

1977 • 170 citations

Inherited Immunoglobulin Idiotypes of the Mouse

1977 • 168 citations

Cellular basis of regulation of expression of idiotype. I. T-suppressor cells specific for MOPC 460 idiotype regulate the expression of cells secreting anti-TNP antibodies bearing 460 idiotype.

1979 • 162 citations

Inheritance of an idiotype associated with the immune response of inbred mice to phosphorylcholine

1972 • 157 citations

Studies of Structure and Immunosuppression of a Cross‐Reactive Idiotype in Strain A Mice

1977 • 134 citations

CLONAL NATURE OF THE IMMUNE RESPONSE TO PHOSPHORYLCHOLINE

1974 • 127 citations

Control of Idiotope Expression by Monoclonal Anti-Idiotope Antibodies

1980 • 112 citations

Mice whose B cells cannot produce the T15 idiotype also lack an antigen-specific helper T cell required for T15 expression.

1979 • 102 citations

In Vitro Tolerance Induction of Bone Marrow Cells: A Marker for B Cell Maturation

1977 • 102 citations

The genetic basis of antibody production: The dominant anti‐arsonate idiotype response of the strain a mouse

1982 • 100 citations

Expression of new idiotypes following neonatal idiotypic suppression of a dominant clone

1976 • 100 citations

Epitope-Specific Regulation

1983 • 99 citations

Regulatory idiotopes and immune networks: a hypothesis

1982 • 97 citations

Neonatal Tolerance Induced by Antibody against Antigen-Specific Receptor

1974 • 97 citations

The genetic control of antibody variable regions in the mouse

1978 • 95 citations

Antigen-specific and nonspecific mediators of T cell/B cell cooperation. I. Evidence for their production by different T cells.

1975 • 94 citations

Absence of an antigen‐specific helper T cell required for the expression of the Tn 15 idiotype in mice treated with anti‐μ antibody

1980 • 92 citations

Inability of mice with a defect in B-lymphocyte maturation to respond to phosphorycholine on immunogenic carriers.

1977 • 83 citations

Late acquisition of a germ line antibody specificity

1976 • 81 citations

Purification of functional, determinant-specific, idiotype-bearing murine T cells

1978 • 80 citations

Clonal nature of the immune response to phosphorylcholine. II. Idiotypic specificity and binding characteristics of anti-phosphorylcholine antibodies.

1974 • 80 citations

Anti-idiotype induced regulation of helper cell function for the response to phosphorylcholine in adult BALB/c mice.

1978 • 76 citations

Antigen‐specific stimulation and trans‐stimulation of T cells in long‐term culture

1979 • 76 citations

Immunoglobulin Structure-Function Correlates: Antigen Binding and Idiotypes

1983 • 74 citations

Immune response to levan. I. Kinetics and ontogeny of anti-levan and anti-inulin antibody response and of expression of cross-reactive idiotype.

1978 • 73 citations

Uniformity in the clonal repertoire for the immune response to phosphorylcholine in mice

1976 • 69 citations

Immunologic memory to phosphorylcholine. II. PC-KLH induces two antibody populations that dominate different isotypes.

1982 • 68 citations

Polymorphism in anti-phosphocholine antibodies reflecting evolution of immunoglobulin families.

1983 • 63 citations

Distinct B Cell Subpopulations Differ in Their Genetic Requirements for Activation by T Helper Cells

1982 • 63 citations

Size differences among immunoglobulin heavy chains from phosphorylcholine-binding proteins.

1976 • 61 citations

Cell-to-cell interaction controlled by immunoglobulin genes. Role of Thy-1-, Lyt-1+, Ig+ (B') cell in allotype-restricted antibody production.

1982 • 61 citations

Idiotype suppression by maternal influence

1977 • 58 citations

Subclass restriction of murine antibodies

1982 • 56 citations

Antigen-Specific and Nonspecific Mediators of T Cell/B Cell Cooperation

1975 • 55 citations

Antigen-specific helper T cells required for dominant idiotype expression are not H-2 restricted

1981 • 55 citations

Cell cooperation during in vivo anti‐hapten antibody responses: V. Two synergistic Ly‐1⁺23⁻ helper T cells with distinctive specificities

1980 • 53 citations

The Interplay of Evolution and Environment in B-cell Diversification

1977 • 49 citations

Nucleic acid and protein sequences of phosphocholine-binding light chains.

1981 • 45 citations

Suppressor T Cells: Presence in Mice Rendered Tolerant by Neonatal Treatment with Anti-Receptor Antibody or Antigen

1977 • 44 citations

Epitope-specific regulation. II. A bistable, Igh-restricted regulatory mechanism central to immunologic memory

1982 • 43 citations

Suppression by autogenous complementary idiotypes: the priority of the first response.

1976 • 42 citations

Functionally distinct helper T cells enriched under different culture conditions cooperate with different B cells.

1982 • 40 citations

Immune Response to Levan

1978 • 39 citations

Immune response to levan. II. T independence of suppression of cross-reactive idiotypes by anti-idiotype antibodies.

1979 • 39 citations

Anti-phosphocholine hybridoma antibodies. II. Functional analysis of binding sites within three antibody families.

1981 • 39 citations

Generation of idiotype-specific T cell help through network perturbation.

1981 • 38 citations

Susceptibility to in vitro tolerance induction of adult B cells from mice with an X-linked B-cell defect.

1980 • 33 citations

Induction and characterization of “autologous” anti‐idiotypic antibodies

1977 • 29 citations

Immunologic memory to phosphorylcholine in vitro. I. Asymmetric expression of clonal dominance.

1981 • 28 citations

Epitope-specific and idiotype-specific cellular interactions in a model protein antigen system

1980 • 28 citations

Clonal nature of the immune response to phosphorylcholine. III. Species-specific binding characteristics of rodent anti-phosphorylcholine antibodies.

1974 • 27 citations

Mechanism of neonatal idiotype suppression. II. Alterations in the T cell compartment suppress the maturation of B cell precursors.

1980 • 25 citations

Antibodies from the Lyb-5- B cell subset predominate in the secondary IgG response to phosphocholine.

1982 • 24 citations

In vitro tolerance induction of neonatal murine B cells as a probe for the study of B-cell diversification.

1977 • 24 citations

CBA/N X BALB/cJ F1 male and female mice can be primed to express quantitatively equivalent secondary anti-phosphocholine responses.

1981 • 22 citations

Clonotypes of anti-phosphocholine antibodies induced with Proteus morganii (Potter). I. Structural and idiotypic similarities in a diverse repertoire.

1980 • 21 citations

Tolerance rendered by neonatal treatment with anti-idiotypic antibodies: Induction and maintenance in athymic mice

1978 • 19 citations

Immunologic memory to phosphorylcholine

1982 • 17 citations

Mechanisms of idiotype suppression. IV. Functional neutralization in mixtures of idiotype-specific suppressor and hapten-specific suppressor T cells.

1981 • 17 citations

Mechanism of neonatal idiotype suppression. I. State of the suppressed B cells.

1980 • 16 citations

Functional heterogeneity of the Lyb-5- B cell subpopulation: mutant xid B cells and normal Lyb-5- B cells differ in their responsiveness to phenol-extracted lipopolysaccharide.

1983 • 15 citations

Inheritance patterns of idiotype expression: maternal-fetal immune regulatory networks

1981 • 13 citations

Clonal nature of the immune response to phosphocholine. IX. Heterogeneity among antibodies bearing M511 idiotypic determinants.

1980 • 12 citations

Dynamics of B cell repertoire formation: normal patterns of clonal turnover are altered by ligand interaction.

1982 • 12 citations

Structural Evidence for a Polymorphic or Allelic form of the Heavy Chain Variable Region

1979 • 10 citations

Expression of a distinct B cell clonotype profile after recovery from antigen‐induced unresponsiveness

1982 • 9 citations

ANALOGOUS DUAL SPECIFICITY OF HELPER T CELLS COOPERATING IN THE GENERATION OF CLONALLY RESTRICTED ANTIBODY RESPONSES

1980 • 8 citations

Mice with the xid defect have helper cells for T15 idiotype-dominant anti-phosphorylcholine primary and secondary plaque-forming cells responses.

1982 • 8 citations

Mechanisms of idiotype suppression. II. Requirement of specific antigen for B cell inactivation by anti-idiotype antibody.

1979 • 8 citations

Alteration of immunologic function through early ontogenetic experiences Selective inactivation of T15‐positive B cells in neonatal mice is related to receptor avidity and is independent of thymus function

1983 • 7 citations

Helper T lymphocytes from xid and normal mice support anti-phosphocholine antibody responses with equivalent T15, 511, and 603 idiotypic composition.

1984 • 6 citations

Regulation of T15 idiotype dominance. I. Mice expressing the xid immune defect provide normal help to T15+ B cell precursors.

1982 • 6 citations

Thymus-independent induction and antigen-dependent recovery of idiotype-specific suppression

1983 • 3 citations