DNA looping by Ku and the DNA-dependent protein kinase

[12] One-step gene disruption in yeast

1983 • 3,302 citations

Transformation of yeast.

1978 • 2,267 citations

Yeast transformation: a model system for the study of recombination.

1981 • 1,491 citations

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

1993 • 1,219 citations

Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination

1985 • 978 citations

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation

1995 • 862 citations

DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1995 • 742 citations

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

1994 • 637 citations

High frequency targeting of genes to specific sites in the mammalian genome

1986 • 619 citations

DNA-Dependent Kinase (p350) as a Candidate Gene for the Murine SCID Defect

1995 • 610 citations

Absence of p350 Subunit of DNA-Activated Protein Kinase from a Radiosensitive Human Cell Line

1995 • 530 citations

Mechanism of interaction between Ku protein and DNA.

1986 • 485 citations

Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction.

1986 • 465 citations

Yeast recombination: the association between double-strand gap repair and crossing-over.

1983 • 432 citations

Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen.

1990 • 415 citations

DNA LOOPING

1992 • 408 citations

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II.

1992 • 367 citations

Restoration of X-ray Resistance and V(D)J Recombination in Mutant Cells by Ku cDNA

1994 • 351 citations

DNA looping between sites for transcriptional activation: self-association of DNA-bound Sp1.

1991 • 348 citations

DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK

1995 • 344 citations

DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair.

1995 • 342 citations

Mechanisms of nonhomologous recombination in mammalian cells.

1985 • 314 citations

Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks.

1993 • 311 citations

Transforming DNA integrates into the host chromosome

1981 • 311 citations

VDJ recombination

1992 • 307 citations

The DNA-dependent Protein Kinase Is Inactivated by Autophosphorylation of the Catalytic Subunit

1996 • 287 citations

Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells.

1995 • 286 citations

A DNA-activated protein kinase from HeLa cell nuclei.

1990 • 285 citations

Action at a distance: DNA-looping and initiation of transcription

1995 • 276 citations

HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex

1989 • 273 citations

DNA looping and Sp1 multimer links: a mechanism for transcriptional synergism and enhancement.

1991 • 254 citations

Menage á trois: Double strand break repair, V(D)J recombination and DNA-PK

1995 • 245 citations

DNA damage and the DNA-activated protein kinase

1993 • 237 citations

ELECTRON MICROSCOPE VISUALIZATION OF CHROMATIN AND OTHER DNA-PROTEIN COMPLEXES

1978 • 230 citations

Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen.

1994 • 225 citations

Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks.

1994 • 215 citations

A novel pathway of DNA end-to-end joining

1990 • 213 citations

Sequence-specific DNA binding by Ku autoantigen and its effects on transcription

1996 • 211 citations

Analysis of the mechanism of interaction of simian Ku protein with DNA

1991 • 207 citations

Purification and characterization of a template-associated protein kinase that phosphorylates RNA polymerase II

1993 • 184 citations

Joining of nonhomologous DNA double strand breaksin vitro

1988 • 166 citations

Recombination in mouse L cells between DNA introduced into cells and homologous chromosomal sequences.

1985 • 165 citations

Nonhomologous Recombination in Mammalian Cells: Role for Short Sequence Homologies in the Joining Reaction

1986 • 154 citations

Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome.

1990 • 152 citations

Relative rates of homologous and nonhomologous recombination in transfected DNA.

1985 • 145 citations

Human Cells Contain a DNA-Activated Protein Kinase that Phosphorylates Simian Virus 40 T Antigen, Mouse p53, and the Human Ku Autoantigen

1990 • 144 citations

Purification and characterization of proximal sequence element-binding protein 1, a transcription activating protein related to Ku and TREF that binds the proximal sequence element of the human U1 promoter.

1990 • 141 citations

Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen.

1995 • 138 citations

p53 oligomerization and DNA looping are linked with transcriptional activation.

1994 • 127 citations

Mechanisms of Nonhomologous Recombination in Mammalian Cells

1985 • 125 citations

Homologous Recombination between Defective neo Genes in Mouse 3T6 Cells

1984 • 111 citations

A DNA-Activated Protein Kinase from HeLa Cell Nuclei

1990 • 109 citations

Repair and Recombination: How to make ends meet

1995 • 101 citations

Ku polypeptides synthesized in vitro assemble into complexes which recognize ends of double-stranded DNA.

1992 • 98 citations

A Constitutive Heat Shock Element-binding Factor Is Immunologically Identical to the Ku Autoantigen

1995 • 75 citations

Promoter-dependent phosphorylation of RNA polymerase II by a template-bound kinase. Association with transcriptional initiation

1991 • 73 citations

Disruption of DNA-PK in Ku80 mutant xrs-6 and the implications in DNA double-strand break repair

1996 • 72 citations

Purification of the sequence-specific transcription factor CTCBF, involved in the control of human collagen IV genes: subunits with homology to Ku antigen.

1995 • 71 citations

Purification and characterization of Ku-2, an octamer-binding protein related to the autoantigen Ku.

1991 • 62 citations

A DNA-binding activity, TRAC, specific for the TRA element of the transferrin receptor gene copurifies with the Ku autoantigen.

1994 • 46 citations

Enhancer 1 binding factor, a Ku-related protein, is a positive regulator of RNA polymerase I transcription initiation.

1994 • 42 citations

DNA-dependent protein kinase defects are linked to deficiencies in DNA repair and V(D)J recombination

1996 • 31 citations

Enhancer 1 binding factor (E1BF), a Ku-related protein, is a growth-regulated RNA polymerase I transcription factor: association of a repressor activity with purified E1BF from serum-deprived cells.

1994 • 27 citations

Cell cycle-dependent migration of the DNA-binding protein Ku80 into nucleoli

1992 • 26 citations

Chapter 6 Electron Microscopic Visualization of DNA in Association with Cellular Components

1974 • 24 citations

The BCL2 major breakpoint region is a sequence- and cell-cycle-specific binding site of the Ku antigen.

1995 • 18 citations

E1BF/Ku interacts physically and functionally with the core promoter binding factor CPBF and promotes the basal transcription of rat and human ribosomal RNA genes.

1995 • 15 citations