Genome-wide detection of tissue-specific alternative splicing in the human transcriptome

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

SMART, a simple modular architecture research tool: Identification of signaling domains

1998 • 3,523 citations

A hidden Markov model for predicting transmembrane helices in protein sequences.

1998 • 2,485 citations

Why genes in pieces?

1978 • 2,256 citations

The Jackknife and the Bootstrap for General Stationary Observations

1989 • 2,213 citations

A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells

1991 • 1,685 citations

hnRNP PROTEINS AND THE BIOGENESIS OF mRNA

1993 • 1,486 citations

Human Hypertension Caused by Mutations in WNK Kinases

2001 • 1,427 citations

A genomic view of alternative splicing

2002 • 1,307 citations

Pfam: A comprehensive database of protein domain families based on seed alignments

1997 • 1,211 citations

Alternative pre-mRNA splicing: the logic of combinatorial control

2000 • 892 citations

Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300

1998 • 812 citations

hnRNP complexes: composition, structure, and function

1999 • 794 citations

Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum

1994 • 793 citations

Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In Vivo

1998 • 723 citations

Genome-wide detection of alternative splicing in expressed sequences of human genes

2001 • 688 citations

The superfamily of arginine/serine-rich splicing factors.

1995 • 671 citations

SR proteins and splicing control.

1996 • 668 citations

ALTERNATIVE SPLICING OF PRE-mRNA: Developmental Consequences and Mechanisms of Regulation

1998 • 644 citations

Frequent Alternative Splicing of Human Genes

1999 • 553 citations

WNK1, a Novel Mammalian Serine/Threonine Protein Kinase Lacking the Catalytic Lysine in Subdomain II

2000 • 503 citations

Nova-1 Regulates Neuron-Specific Alternative Splicing and Is Essential for Neuronal Viability

2000 • 415 citations

Gene Structure Prediction and Alternative Splicing Analysis Using Genomically Aligned ESTs

2001 • 410 citations

Genomewide Analysis of mRNA Processing in Yeast Using Splicing-Specific Microarrays

2002 • 406 citations

Pieces of the puzzle: expressed sequence tags and the catalog of human genes

1997 • 380 citations

A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1

1998 • 336 citations

Interferon Regulatory Factor 3 and CREB-Binding Protein/p300 Are Subunits of Double-Stranded RNA-Activated Transcription Factor DRAF1

1998 • 334 citations

Alternative RNA splicing in the nervous system

2001 • 331 citations

Genome-wide bioinformatic and molecular analysis of introns in Saccharomyces cerevisiae

1999 • 320 citations

The Human Nramp2 Gene: Characterization of the Gene Structure, Alternative Splicing, Promoter Region and Polymorphisms

1998 • 314 citations

Cooperative Assembly of an hnRNP Complex Induced by a Tissue-Specific Homolog of Polypyrimidine Tract Binding Protein

2000 • 312 citations

EST comparison indicates 38% of human mRNAs contain possible alternative splice forms

2000 • 303 citations

Essential Role of Interferon Regulatory Factor 3 in Direct Activation of RANTES Chemokine Transcription

1999 • 273 citations

WNK kinases, a novel protein kinase subfamily in multi-cellular organisms

2001 • 264 citations

Profiling alternative splicing on fiber-optic arrays

2002 • 211 citations

The γ-subunit of the coatomer complex binds Cdc42 to mediate transformation

2000 • 211 citations

A new type of mutation causes a splicing defect in ATM

2002 • 210 citations

Transgenic expression of IFN-alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration.

1998 • 210 citations

Binding of hnRNP H to an exonic splicing silencer is involved in the regulation of alternative splicing of the rat beta -tropomyosin gene

1999 • 195 citations

Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-Δ11b

1997 • 195 citations

Structural and functional neuropathology in transgenic mice with CNS expression of IFN-α1Published on the World Wide Web on 17 March 1999.1

1999 • 173 citations

Test of intron predictions reveals novel splice sites, alternatively spliced mRNAs and new introns in meiotically regulated genes of yeast

2000 • 173 citations

Multiple roles for Cdc42 in cell regulation

2001 • 165 citations

An Alternative-Exon Database and Its Statistical Analysis

2000 • 162 citations

Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK

1999 • 162 citations

RNA processing and human disease

2000 • 135 citations

Alternative Splicing and Programmed Cell Death

1999 • 133 citations

Predicting Splice Variant from DNA Chip Expression Data

2001 • 121 citations

Computational analysis of candidate intron regulatory elements for tissue-specific alternative pre-mRNA splicing

2001 • 116 citations

Alternative Gene Form Discovery and Candidate Gene Selection from Gene Indexing Projects

1998 • 105 citations

A sequence compilation and comparison of exons that are alternatively spliced in neurons

1994 • 105 citations

Alternative splicing of the mouse profilin II gene generates functionally different profilin isoforms

2000 • 101 citations

Nonclathrin coat protein gamma, a subunit of coatomer, binds to the cytoplasmic dilysine motif of membrane proteins of the early secretory pathway.

1996 • 94 citations

Profilin II Is Alternatively Spliced, Resulting in Profilin Isoforms That Are Differentially Expressed and Have Distinct Biochemical Properties

2000 • 94 citations

A single binding site for dilysine retrieval motifs and p23 within the γ subunit of coatomer

1998 • 90 citations

The Intronerator: exploring introns and alternative splicing in Caenorhabditis elegans

2000 • 89 citations

Human membrane cofactor protein (MCP, CD46): multiple isoforms and functions

1999 • 85 citations

Neuronatin mRNA: alternatively spliced forms of a novel brain-specific mammalian developmental gene

1995 • 80 citations

Gaucher disease: A G+1----A+1 IVS2 splice donor site mutation causing exon 2 skipping in the acid beta-glucosidase mRNA.

1992 • 59 citations

Functional Characterization of Interferon Regulatory Factor 3a (IRF-3a), an Alternative Splice Isoform of IRF-3

2001 • 58 citations

ASDB: database of alternatively spliced genes

1999 • 57 citations

AsMamDB: an alternative splice database of mammals

2001 • 51 citations

ASDB: database of alternatively spliced genes

2000 • 47 citations

Characterization of tissue‐specific LIM domain protein (FHL1C) which is an alternatively spliced isoform of a human LIM‐only protein (FHL1)

2001 • 46 citations

The GeneMine system for genome/proteome annotation and collaborative data mining

2001 • 39 citations

Genomic Organization and Chromosomal Location of MurineCdc42

1996 • 39 citations

Tissue-specific alternative splicing of hybrid Shaker/lacZ genes correlates with kinetic differences in Shaker K+ currents in vivo

1995 • 33 citations

Fatty aldehyde dehydrogenase: genomic structure, expression and mutation analysis in Sjögren–Larsson syndrome

2001 • 33 citations

Dual utilization of an acceptor/donor splice site governs the alternative splicing of the IRF-3 gene

2000 • 33 citations

Quantitative analysis of glucose‐6‐phosphate translocase gene expression in various human tissues and haematopoietic progenitor cells

2000 • 31 citations

Human variant glucose-6-phosphate transporter is active in microsomal transport

2000 • 25 citations

Genomic Organization, Expression, and Alternate Splicing of the Mouse Fatty Aldehyde Dehydrogenase Gene

2000 • 22 citations

Heterologous expression, functional characterization and localization of two isoforms of the monkey iron transporter Nramp2

2000 • 17 citations

The human CDC42 gene: genomic organization, evidence for the existence of a putative pseudogene and exclusion as a SJS1 candidate gene

1999 • 13 citations

Multiple splice forms of ribonuclease-inhibitor mRNA differ in the 5′-untranslated region

1989 • 11 citations

Regulated Splicing of an Alternative Exon of beta-Tropomyosin Pre-mRNAs in Myogenic Cells Depends on the Strength of Pyrimidine-Rich Intronic Enhancer Elements

1999 • 11 citations

Spontaneous frequency of exon skipping in the human HPRT gene

2002 • 9 citations

An extensive list of genes that produce alternative transcripts in the mouse.

1999 • 6 citations