Genome-wide bioinformatic and molecular analysis of introns in Saccharomyces cerevisiae

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Life with 6000 Genes

1996 • 4,125 citations

Hidden Markov Models in Computational Biology

1994 • 1,954 citations

[19] Targeting, disruption, replacement, and allele rescue: Integrative DNA transformation in yeast

1991 • 1,369 citations

Mechanical Devices of the Spliceosome: Motors, Clocks, Springs, and Things

1998 • 1,121 citations

A survey on intron and exon lengths

1988 • 569 citations

The yeast genome project: what did we learn?

1996 • 540 citations

Recognition of the TACTAAC box during mRNA splicing in yeast involves base pairing to the U2-like snRNA

1987 • 508 citations

Hidden Markov models for sequence analysis: extension and analysis of the basic method

1996 • 448 citations

A U1 snRNA:pre-mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5′ cleavage site.

1988 • 364 citations

The Splicing Factor BBP Interacts Specifically with the Pre-mRNA Branchpoint Sequence UACUAAC

1997 • 327 citations

[11] DNA of Saccharomyces cerevisiae

1991 • 308 citations

5' splice site selection in yeast: genetic alterations in base-pairing with U1 reveal additional requirements.

1988 • 307 citations

An RNA Processing Activity That Debranches RNA Lariats

1985 • 300 citations

Mutations in U6 snRNA that Alter Splice Site Specificity: Implications for the Active Site

1993 • 283 citations

Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon.

1995 • 279 citations

Involvement of U6 snRNA in 5′ Splice Site Selection

1993 • 265 citations

Isolation and characterization of the gene encoding yeast debranching enzyme

1991 • 238 citations

Scanning and competition between AGs are involved in 3' splice site selection in mammalian introns.

1993 • 194 citations

The Meiosis-Specific Hop2 Protein of S. cerevisiae Ensures Synapsis between Homologous Chromosomes

1998 • 193 citations

Mutational analysis of pre-mRNA splicing in Saccharomyces cerevisiae using a sensitive new reporter gene, CUP1.

1993 • 178 citations

The structure and evolution of subtelomeric Y' repeats in Saccharomyces cerevisiae.

1992 • 171 citations

Extensive interactions of PRP8 protein with the 5′ and 3′ splice sites during splicing suggest a role in stabilization of exon alignment by U5 snRNA.

1995 • 166 citations

MOB1, an Essential Yeast Gene Required for Completion of Mitosis and Maintenance of Ploidy

1998 • 166 citations

Antisense snoRNAs: a family of nucleolar RNAs with long complementarities to rRNA

1995 • 165 citations

Yeast mutants sensitive to antimicrotubule drugs define three genes that affect microtubule function.

1990 • 157 citations

Nuclear pre‐mRNA splicing in yeast

1989 • 156 citations

Mutations in a yeast intron demonstrate the importance of specific conserved nucleotides for the two stages of nuclear mRNA splicing

1986 • 150 citations

An essential splicing factor, SLU7, mediates 3' splice site choice in yeast.

1992 • 144 citations

The second catalytic step of pre-mRNA splicing.

1995 • 142 citations

Ribosomal Protein L32 of Saccharomyces cerevisiae Influences both the Splicing of Its Own Transcript and the Processing of rRNA

1997 • 137 citations

The yeast MATa1 gene contains two introns.

1984 • 134 citations

A point mutation in the conserved hexanucleotide at a yeast 5′ splice junction uncouples recognition, cleavage, and ligation

1985 • 129 citations

The Invariant U5 snRNA Loop 1 Sequence Is Dispensable for the First Catalytic Step of pre-mRNA Splicing in Yeast

1996 • 120 citations

A U-rich tract enhances usage of an alternative 3′ splice site in yeast

1991 • 119 citations

A quantitative analysis of the effects of 5′ junction and TACTAAC box mutants and mutant combinations on yeast mRNA splicing

1985 • 115 citations

Scanning and Competition between AGs Are Involved in 3' Splice Site Selection in Mammalian Introns

1993 • 114 citations

Splice site choice and splicing efficiency are positively influenced by pre-mRNA intramolecular base pairing in yeast

1993 • 94 citations

An RNA structure involved in feedback regulation of splicing and of translation is critical for biological fitness.

1996 • 86 citations

An Intron in the Genes for U3 Small Bucleolar RNAs of the Yeast Saccharomyces cerevisiae

1990 • 86 citations

Requirement for SLU7 in yeast pre-mRNA splicing is dictated by the distance between the branchpoint and the 3' splice site.

1996 • 86 citations

Intron self-complementarity enforces exon inclusion in a yeast pre-mRNA

1997 • 84 citations

Unexpected point mutations activate cryptic 3' splice sites by perturbing a natural secondary structure within a yeast intron.

1991 • 81 citations

RNA splicing and intron turnover are greatly diminished by a mutant yeast branch point.

1986 • 80 citations

Exon mutations uncouple 5′ splice site selection from U1 snRNA pairing

1990 • 78 citations

The role of branchpoint-3' splice site spacing and interaction between intron terminal nucleotides in 3' splice site selection in Saccharomyces cerevisiae

1997 • 77 citations

U24, a novel intron-encoded small nucleolar RNA with two 12 nt long, phylogenetically conserved complementaritiesm to 28S rRNA

1995 • 76 citations

Rearrangement of snRNA Structure during Assembly and Function of the Spliceosome

1995 • 75 citations

Autoregulation of expression of the yeast Dbp2p ‘DEAD-box’ protein is mediated by sequences in the conserved DBP2 intron.

1995 • 73 citations

Yeast lariat debranching enzyme. Substrate and sequence specificity.

1994 • 72 citations

Functional and physical interaction between the yeast splicing factors Slu7 and Prp18

1997 • 69 citations

Expression strategies of the yeast retrotransposon Ty: a short sequence directs ribosomal frameshifting

1986 • 69 citations

A specific screen for oligosaccharyltransferase mutations identifies the 9kDa OST5 protein required for optimal activity invivo and invitro

1997 • 68 citations

Efficient association of U2 snRNPs with pre-mRNA requires an essential U2 RNA structural element.

1991 • 65 citations

A human ubiquitin-conjugating enzyme homologous to yeast UBC8.

1994 • 64 citations

In vivo commitment to splicing in yeast involves the nucleotide upstream from the branch site conserved sequence and the Mud2 protein

1997 • 64 citations

Ribosomal protein L30 is dispensable in the yeast Saccharomyces cerevisiae.

1990 • 63 citations

Processing of the Intron-Encoded U18 Small Nucleolar RNA in the Yeast Saccharomyces cerevisiaeRelies on Both Exo- and Endonucleolytic Activities

1998 • 62 citations

YRA1, an essential Saccharomyces cerevisiae gene, encodes a novel nuclear protein with RNA annealing activity.

1997 • 56 citations

A yeast ribosomal protein gene whose intron is in the 5' leader.

1984 • 55 citations

RNA structural patterns and splicing: molecular basis for an RNA-based enhancer.

1995 • 55 citations

Intramolecular structure in yeast introns aids the early steps of in vitro spliceosome assembly.

1996 • 49 citations

Specific accessory sequences in Saccharomyces cerevisiae introns control assembly of pre-mRNAs into spliceosomes.

1987 • 49 citations

Extended N‐terminal sequencing of proteins of the large ribosomal subunit from yeast mitochondria

1991 • 48 citations

Automatic intron detection in nuclear DNA sequences of Saccharomyces cerevisiae

1995 • 46 citations

Effects on mRNA splicing of mutations in the 3' region of the Saccharomyces cerevisiae actin intron.

1987 • 43 citations

Identification and Characterization of the Genes for Mitochondrial Ribosomal Proteins of Saccharomyces Cerevisiae

1997 • 42 citations

Mutational analysis of the interactions between u1 small nuclear rna and pre-mrna of yeast

1989 • 42 citations

The yeast omnipotent suppressor SUP46 encodes a ribosomal protein which is a functional and structural homolog of the Escherichia coli S4 ram protein.

1992 • 40 citations

Yeast ribosomal proteins: XIII.Saccharomyces cerevisiaeYL8A gene, interrupted with two introns, encodes a homolog of mammalian L7

1992 • 33 citations

Molecular and genetic characterization ofSLC1, a putativeSaccharomyces cerevisiae homolog of the metazoan cytoplasmic dynein light chain 1

1996 • 31 citations

Removal of an intron with unique 3′ branch site creates an amino-terminal protein sequence directing the scERV1 gene product to mitochondria

1996 • 27 citations

Examination of the Intron in the meiosis-specific recombination gene REC114 in Saccharomyces

1997 • 25 citations

The gene for yeast ribosomal protein S31 contains an intron in the leader sequence

1985 • 23 citations

The untranslated header of nuclear COX4 gene ofSaccharomyces cerevisiaecontains an intron

1987 • 23 citations

Mutations in GCR3, a Gene Involved in the Expression of Glycolytic Genes in Saccharomyces cerevisiae, Suppress the Temperature-Sensitive Growth of hpr1 Mutants

1996 • 21 citations

RNA lariat debranching enzyme as tool for analyzing RNA structure

1990 • 20 citations

Yeast Pre-mRNA Splicing Requires a Minimum Distance between the 5′ Splice Site and the Internal Branch Acceptor Site

1987 • 18 citations

Prevalence and distribution of introns in non-ribosomal protein genes of yeast

1994 • 17 citations

Ribosomal Protein L30 Is Dispensable in the Yeast Saccharomyces cerevisiae

1990 • 16 citations

Effects on mRNA Splicing of Mutations in the 3′ Region of the Saccharomyces cerevisiae Actin Intron

1987 • 15 citations

Splicing and spliceosome formation of the yeastMATa1transcript require a minimum distance from the 5' splice site to the internal branch acceptor site

1988 • 13 citations

The evolutionary relationships between homologs of ribosomal YL8 protein and YL8-like proteins

1995 • 11 citations

<scp>II</scp>. Yeast sequencing reports. The two genes encoding yeast ribosomal protein S8 reside on different chromosomes, and are closely linked to the hsp70 stress protein genes SSA3 and SSA4

1994 • 5 citations