Congenic mice: cutting tools for complex immune disorders

Initial sequencing and comparative analysis of the mouse genome

2002 • 6,971 citations

Systematic functional analysis of the Caenorhabditis elegans genome using RNAi

2003 • 3,597 citations

RNA interference

2002 • 3,369 citations

Functional genomic analysis of C. elegans chromosome I by systematic RNA interference

2000 • 1,767 citations

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

2002 • 1,644 citations

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs

2002 • 1,612 citations

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

2002 • 1,526 citations

The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

1993 • 1,438 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.

1996 • 1,382 citations

On the Role of RNA Amplification in dsRNA-Triggered Gene Silencing

2001 • 1,282 citations

RNA interference in adult mice

2002 • 1,060 citations

RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

2002 • 1,037 citations

Mapping and analysis of quantitative trait loci in experimental populations

2002 • 783 citations

Genetic Analysis of Autoimmune Disease

1996 • 739 citations

The Nonobese Diabetic Mouse as a Model of Autoimmune Diabetes: Immune Dysregulation Gets the NOD

1997 • 685 citations

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

2000 • 661 citations

Type-I Diabetes: A Chronic Autoimmune Disease of Human, Mouse, and Rat

1990 • 650 citations

Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases

1998 • 601 citations

B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice.

1996 • 581 citations

Dissecting the architecture of a quantitative trait locus in yeast

2002 • 549 citations

Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia.

1994 • 498 citations

Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family

2001 • 487 citations

The mosaic structure of variation in the laboratory mouse genome

2002 • 474 citations

Analysing complex genetic traits with chromosome substitution strains

2000 • 467 citations

The NOD Mouse: Recessive Diabetogenic Gene in the Major Histocompatibility Complex

1986 • 424 citations

Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse

2000 • 423 citations

Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains

1997 • 413 citations

Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains

2000 • 397 citations

Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma

1997 • 373 citations

Speed congenics: a classic technique in the fast lane (relatively speaking)

1997 • 347 citations

The major murine systemic lupus erythematosus susceptibility locus,Sle1, is a cluster of functionally related genes

2001 • 332 citations

Inbred strains in biomedical research

1981 • 318 citations

Size matters: use of YACs, BACs and PACs in transgenic animals.

2001 • 317 citations

A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice.

1984 • 302 citations

In Silico Mapping of Complex Disease-Related Traits in Mice

2001 • 294 citations

Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus.

1997 • 279 citations

Functional dissection of systemic lupus erythematosus using congenic mouse strains.

1997 • 268 citations

Inbred Strains in Biomedical Research

1979 • 263 citations

Separable Roles for rent1/hUpf1 in Altered Splicing and Decay of Nonsense Transcripts

2002 • 257 citations

Control of Autoimmune Diabetes in NOD Mice by GAD Expression or Suppression in β Cells

1999 • 248 citations

Engineering chromosomal rearrangements in mice

2001 • 243 citations

A mouse phenome project

2000 • 218 citations

The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs

2000 • 208 citations

Modeling Allergic Asthma in Mice

2002 • 200 citations

Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort

2002 • 200 citations

Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes.

1992 • 178 citations

A Short Primer on RNAi

2001 • 176 citations

The NOD Idd9 Genetic Interval Influences the Pathogenicity of Insulitis and Contains Molecular Variants of Cd30, Tnfr2, and Cd137

2000 • 163 citations

NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.

2000 • 157 citations

Genetic Influences on the End-Stage Effector Phase of Arthritis

2001 • 149 citations

Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene.

1994 • 147 citations

Congenic Mapping of the Type 1 Diabetes Locus,Idd3, to a 780-kb Region of Mouse Chromosome 3: Identification of a Candidate Segment of Ancestral DNA by Haplotype Mapping

2000 • 140 citations

Crosses of NOD Mice With the Related NON Strain: A Polygenic Model for IDDM

1995 • 140 citations

Functional Annotation of Mouse Genome Sequences

2001 • 134 citations

Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1.

1997 • 129 citations

RNA interference: antiviral defense and genetic tool

2002 • 124 citations

Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes.

1994 • 123 citations

Genome-Wide ENU Mutagenesis to Reveal Immune Regulators

2001 • 120 citations

Understanding autoimmune diabetes: insights from mouse models

2002 • 118 citations

Recombinant Congenic Strains Derived from A/J and C57BL/6J: A Tool for Genetic Dissection of Complex Traits

2001 • 118 citations

Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse Chromosome 3

1998 • 116 citations

The allelic structure of common disease

2002 • 106 citations

Linkage on Chromosome 3 of Autoimmune Diabetes and Defective Fc Receptor for IgG in NOD mice

1993 • 103 citations

Combining mouse congenic strains and microarray gene expression analyses to study a complex trait: the NOD model of type 1 diabetes.

2002 • 101 citations

Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping.

1995 • 98 citations

Genetics of Systemic Autoimmunity in Mouse Models of Lupus

2000 • 96 citations

Identification of a new malaria susceptibility locus (Char4) in recombinant congenic strains of mice

2001 • 89 citations

Genetic Control of Diabetogenesis in NOD/Lt Mice: Development and Analysis of Congenic Stocks

1989 • 88 citations

The Human Genome Project—An Overview

2000 • 86 citations

High-Quality RNA from Cells Isolated by Laser Capture Microdissection

2002 • 82 citations

Functional Genomics of the Endocrine Pancreas

2002 • 81 citations

The Human Genome Project?An Overview

2000 • 80 citations

Genome-Tagged Mice (GTM): Two Sets of Genome-wide Congenic Strains

2001 • 80 citations

The Major Murine Systemic Lupus Erythematosus Susceptibility LocusSle1Results in Abnormal Functions of Both B and T Cells

2002 • 80 citations

Three Loci on Mouse Chromosome 6 Influence Onset and Final Incidence of Type I Diabetes in NOD.C3H Congenic Strains

2001 • 78 citations

Congenic Mapping of the Diabetogenic LocusIdd4to a 5.2-cM Region of Chromosome 11 in NOD Mice

2002 • 73 citations

Pitfalls and Opportunities

1999 • 70 citations

Bronchial asthma: Lessons from murine models

1997 • 60 citations

Functional screening of an asthma QTL in YAC transgenic mice

1999 • 60 citations

Genetic analysis of diabetes and insulitis in an interspecific cross of the nonobese diabetic mouse with Mus spretus.

1993 • 60 citations

Type 1 Diabetes and the Control of Dexamethazone-Induced Apoptosis in Mice Maps to the Same Region on Chromosome 6

1995 • 55 citations

The NOD Mouse as a Model of SLE

2001 • 52 citations

Mouse BAC Ends Quality Assessment and Sequence Analyses

2001 • 52 citations

The Derivation of Highly Germline-Competent Embryonic Stem Cells Containing NOD-Derived Genome

2003 • 49 citations

Use of Coisogenic Host Blastocysts for Efficient Establishment of Germline Chimeras with C57BL/6J ES Cell Lines

2001 • 47 citations

An Efficient Method for High-Fidelity BAC/PAC Retrofitting with a Selectable Marker for Mammalian Cell Transfection

2001 • 43 citations

Further Mapping of the Idd5.1 Locus for Autoimmune Diabetes in NOD Mice

2001 • 43 citations

A new locus for resistance to γ-radiation-induced thymic lymphoma identified using inter-specific consomic and inter-specific recombinant congenic strains of mice

2002 • 42 citations

Molecular Analysis of Complex Tissues Is Facilitated by Laser Capture Microdissection: Critical Role of Upstream Tissue Processing

2001 • 42 citations

Establishment of an embryonic stem (ES) cell line derived from a non‐obese diabetic (NOD) mouse: in vivo differentiation into lymphocytes and potential for germ line transmission

1999 • 41 citations

Genetic basis of autoimmune disease in MRL/lpr mice: dissection of the complex pathological manifestations and their susceptibility loci.

2000 • 40 citations

CTLA-4−/− Mice Display T Cell-apoptosis Resistance Resembling that Ascribed to Autoimmune-prone Non-obese Diabetic (NOD) Mice

2001 • 39 citations

ICA69null Nonobese Diabetic Mice Develop Diabetes, but Resist Disease Acceleration by Cyclophosphamide

2002 • 31 citations

Gene Expression Profiling in Immune Cells Using Microarray

2001 • 28 citations

The increasing value of congenic mice in biomedical research.

1977 • 25 citations

A Personal History of the Mouse Genome

2002 • 24 citations

A toolbox for a small mammal

2002 • 1 citations

Deleted Work

1955 • 0 citations