Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

Cluster analysis and display of genome-wide expression patterns

1998 • 16,410 citations

Axonal Transection in the Lesions of Multiple Sclerosis

1998 • 4,007 citations

Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination

2000 • 3,258 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

1992 • 1,711 citations

The Cloning of a Family of Genes That Encode the Melanocortin Receptors

1992 • 1,616 citations

Anti-inflammatory Activity of IVIG Mediated Through the Inhibitory Fc Receptor

2001 • 1,037 citations

FcR γ chain deletion results in pleiotrophic effector cell defects

1994 • 967 citations

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.

1993 • 959 citations

Identification of autoantibodies associated with myelin damage in multiple sclerosis

1999 • 881 citations

Glutamate excitotoxicity in a model of multiple sclerosis

2000 • 832 citations

Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

1999 • 723 citations

A full genome search in multiple sclerosis

1996 • 666 citations

A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex

1996 • 650 citations

A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22

1996 • 638 citations

IL‐6 and NF‐IL6 in Acute‐Phase Response and Viral Infection

1992 • 540 citations

Neuronal Activity-Dependent Cell Survival Mediated by Transcription Factor MEF2

1999 • 510 citations

Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy

1989 • 394 citations

Clustering of Hepatotoxins Based on Mechanism of Toxicity Using Gene Expression Profiles

2001 • 384 citations

Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis.

1997 • 363 citations

Requirement for Leptin in the Induction and Progression of Autoimmune Encephalomyelitis

2001 • 347 citations

The neuropathology of multiple sclerosis.

2000 • 332 citations

Feature extraction and normalization algorithms for high-density oligonucleotide gene expression array data

2001 • 282 citations

Molecular Characterization of the Gene for Human Cartilage gp-39 (CHI3L1), a Member of the Chitinase Protein Family and Marker for Late Stages of Macrophage Differentiation

1997 • 274 citations

Cytokine accumulations in CSF of multiple sclerosis patients

1990 • 270 citations

Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice.

1997 • 255 citations

Analysis of gene expression in multiple sclerosis lesions using cDNA microarrays

1999 • 245 citations

Assessment of Animal Models for MS and Demyelinating Disease in the Design of Rational Therapy

1999 • 245 citations

Analyzing high-density oligonucleotide gene expression array data

2000 • 198 citations

Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. Identity of key contact residues in the B-cell and T-cell epitopes.

1997 • 190 citations

An unexpected version of horror autotoxicus: anaphylactic shock to a self-peptide

2001 • 187 citations

Experimental autoimmune encephalomyelitis is exacerbated by IL-1 alpha and suppressed by soluble IL-1 receptor.

1991 • 183 citations

Administration of Neutralizing Antibodies to Interleukin-6 (IL-6) Reduces Experimental Autoimmune Encephalomyelitis and Is Associated with Elevated Levels of IL-6 Bioactivity in Central Nervous System and Circulation

1995 • 145 citations

Molecular cloning of M6: Identification of a PLP/DM20 gene family

1993 • 143 citations

Multiple sclerosis : clinical and pathogenetic basis

1997 • 135 citations

Multiple Sclerosis. Clinical and pathogenetic basis.

1997 • 126 citations

G-CSF Therapy of Ongoing Experimental Allergic Encephalomyelitis Via Chemokine- and Cytokine-Based Immune Deviation

2002 • 114 citations

Intravenous immunoglobulin treatment of experimental T cell-mediated autoimmune disease. Upregulation of T cell proliferation and downregulation of tumor necrosis factor alpha secretion.

1994 • 113 citations

Fine specificity of the antibody response to myelin basic protein in the central nervous system in multiple sclerosis: the minimal B-cell epitope and a model of its features.

1995 • 111 citations

Central Nervous System-Targeted Expression of the Complement Inhibitor sCrry Prevents Experimental Allergic Encephalomyelitis

1999 • 93 citations

Isolation and characterization of a novel B cell activation gene.

1993 • 93 citations

Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages.

1992 • 88 citations

Stress and autoimmunity: the neuropeptides corticotropin-releasing factor and urocortin suppress encephalomyelitis via effects on both the hypothalamic-pituitary-adrenal axis and the immune system.

1997 • 88 citations

Multiple sclerosis: expression of molecules of the tumor necrosis factor ligand and receptor families in relationship to the demyelinated plaque.

1998 • 80 citations

Altered inflammatory response and increased neurodegeneration in metallothionein I+II deficient mice during experimental autoimmune encephalomyelitis

2001 • 73 citations

The CD59 antigen ‐ a multifunctional molecule

1992 • 39 citations