The Major Murine Systemic Lupus Erythematosus Susceptibility LocusSle1Results in Abnormal Functions of Both B and T Cells

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

1991 • 1,783 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice

1993 • 732 citations

A Novel Mouse with B Cells but Lacking Serum Antibody Reveals an Antibody-independent Role for B Cells in Murine Lupus

1999 • 694 citations

B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice.

1996 • 581 citations

From T to B and back again: positive feedback in systemic autoimmune disease

2001 • 553 citations

Polygenic control of susceptibility to murine systemic lupus erythematosus

1994 • 484 citations

B Lymphocytes Are Critical Antigen-Presenting Cells for the Initiation of T Cell-Mediated Autoimmune Diabetes in Nonobese Diabetic Mice

1998 • 454 citations

Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains

2000 • 397 citations

Lymphoid Development in Mice Congenitally Lacking T Cell Receptor αβ-Expressing Cells

1992 • 371 citations

Synovium as a source of increased amino-terminal parathyroid hormone-related protein expression in rheumatoid arthritis. A possible role for locally produced parathyroid hormone-related protein in the pathogenesis of rheumatoid arthritis.

1998 • 340 citations

The major murine systemic lupus erythematosus susceptibility locus,Sle1, is a cluster of functionally related genes

2001 • 332 citations

GENETIC SUSCEPTIBILITY TO SYSTEMIC LUPUS ERYTHEMATOSUS

1998 • 313 citations

A New Role for B Cells in Systemic Autoimmunity: B Cells Promote Spontaneous T Cell Activation in MRL-lpr/lprMice

1998 • 301 citations

The central and multiple roles of B cells in lupus pathogenesis

1999 • 286 citations

Functional dissection of systemic lupus erythematosus using congenic mouse strains.

1997 • 268 citations

B Lymphocytes Regulate Dendritic Cell (Dc) Function in Vivo

2000 • 263 citations

B Lymphocytes Are Crucial Antigen-Presenting Cells in the Pathogenic Autoimmune Response to GAD65 Antigen in Nonobese Diabetic Mice

1998 • 259 citations

Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity.

1997 • 234 citations

Cr2, a Candidate Gene in the Murine Sle1c Lupus Susceptibility Locus, Encodes a Dysfunctional Protein

2001 • 213 citations

Epistatic Modifiers of Autoimmunity in a Murine Model of Lupus Nephritis

1999 • 200 citations

Thymus Dependence of Antibody Response: Variation with Dose of Antigen and Class of Antibody

1968 • 195 citations

Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain

1996 • 180 citations

Genetic Dissection of Sle Pathogenesis:Sle3on Murine Chromosome 7 Impacts T Cell Activation, Differentiation, and Cell Death

1999 • 176 citations

Samter's Immunologic Diseases

2001 • 169 citations

Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in αβ(+) T cells

1994 • 167 citations

Genetic dissection of systemic lupus erythematosus

1999 • 158 citations

The genetics of human systemic lupus erythematosus

1998 • 147 citations

NZM2328: A New Mouse Model of Systemic Lupus Erythematosus with Unique Genetic Susceptibility Loci

2001 • 138 citations

Differences in expression of lupus nephritis in New Zealand mixed H-2z homozygous inbred strains of mice derived from New Zealand black and New Zealand white mice. Origins and initial characterization.

1993 • 131 citations

Effect of genetic background on the contribution of New Zealand Black loci to autoimmune lupus nephritis

1996 • 130 citations

Intrinsic B cell defects in NZB and NZW mice contribute to systemic lupus erythematosus in (NZB x NZW)F1 mice.

1996 • 113 citations

Genetic Dissection of SLE Pathogenesis: Adoptive Transfer ofSle1Mediates the Loss of Tolerance by Bone Marrow-Derived B Cells

1999 • 108 citations

Autoantibodies associated with lupus induced by diverse drugs target a similar epitope in the (H2A-H2B)-DNA complex.

1992 • 104 citations

Interpretation of phenotype in genetically engineered mice.

1999 • 95 citations

CD4+CD25+ T-cell development is regulated by at least 2 distinct mechanisms

2002 • 90 citations

Lupus : molecular and cellular pathogenesis

1999 • 72 citations

Lupus Susceptibility Genes on Human Chromosome 1

2000 • 62 citations

Genetic Dissection of Systemic Lupus Erythematosus Pathogenesis: Evidence for Functional Expression ofSle3/5by Non-T Cells

2002 • 59 citations

Lymphocyte proliferation in mice congenitally deficient in T-cell receptor alpha beta + cells.

1994 • 51 citations

The Role of αβ+ T Cells and Homeostatic T Cell Proliferation in Y-Chromosome-Associated Murine Lupus

2001 • 50 citations

Germinal center formation in mice lacking αβ T cells

1996 • 48 citations

Production of pathogenic antibodies: Cognate interactions between autoimmune T and B cells

1998 • 47 citations

Assembly and DNA binding of recombinant Ku (p70/p80) autoantigen defined by a novel monoclonal antibody specific for p70/p80 heterodimers

1994 • 46 citations

Lessons from the NZM2410 Model and Related Strains

2000 • 41 citations

Autoantibodies to Nucleosomes and Histone–DNA Complexes

1997 • 35 citations

B Lymphocytes as Autoantigen‐presenting Cells in the Amplification of Autoimmunity^a

1997 • 33 citations

Analysis of low zone tolerance induction in normal and B cell-deficient mice.

1996 • 25 citations

Mechanisms of the Pathogenic Autoimmune Response in Lupus

1999 • 6 citations