On the Role of RNA Amplification in dsRNA-Triggered Gene Silencing

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

THE GENETICS OF CAENORHABDITIS ELEGANS

1974 • 14,589 citations

Role for a bidentate ribonuclease in the initiation step of RNA interference

2001 • 4,804 citations

RNA interference is mediated by 21- and 22-nucleotide RNAs

2001 • 3,271 citations

RNAi

2000 • 2,596 citations

Functional genomic analysis of C. elegans chromosome I by systematic RNA interference

2000 • 1,767 citations

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

2001 • 1,761 citations

Argonaute2, a Link Between Genetic and Biochemical Analyses of RNAi

2001 • 1,492 citations

The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans

1999 • 1,286 citations

Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA

1998 • 1,121 citations

Use of dsRNA-Mediated Genetic Interference to Demonstrate that frizzled and frizzled 2 Act in the Wingless Pathway

1998 • 1,116 citations

Chapter 19 DNA Transformation

1995 • 1,106 citations

Arabidopsis SGS2 and SGS3 Genes Are Required for Posttranscriptional Gene Silencing and Natural Virus Resistance

2000 • 1,082 citations

An RNA-Dependent RNA Polymerase Gene in Arabidopsis Is Required for Posttranscriptional Gene Silencing Mediated by a Transgene but Not by a Virus

2000 • 1,061 citations

Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems

2001 • 1,055 citations

RNA interference—2001

2001 • 698 citations

Systemic Spread of Sequence-Specific Transgene RNA Degradation in Plants Is Initiated by Localized Introduction of Ectopic Promoterless DNA

1998 • 694 citations

Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase

1999 • 653 citations

EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans

2000 • 546 citations

Functional Anatomy of a dsRNA Trigger

2000 • 397 citations

Genes critical for muscle development and function in Caenorhabditis elegans identified through lethal mutations

1994 • 332 citations

An important role of an inducible RNA-dependent RNA polymerase in plant antiviral defense

2001 • 307 citations

Reverse genetics by chemical mutagenesis in Caenorhabditis elegans

1997 • 282 citations

Target-selected gene inactivation in Caenorhabditis elegans by using a frozen transposon insertion mutant bank.

1993 • 278 citations

Transcriptional and posttranscriptional gene silencing are mechanistically related

2001 • 266 citations

RNA-directed DNA methylation.

2000 • 258 citations

Products of the unc-52 gene in Caenorhabditis elegans are homologous to the core protein of the mammalian basement membrane heparan sulfate proteoglycan.

1993 • 251 citations

Isolation of an RNA-Directed RNA Polymerase–Specific cDNA Clone from Tomato

1998 • 251 citations

Production of antisense RNA leads to effective and specific inhibition of gene expression in C. elegans muscle

1991 • 250 citations

Cosuppression in Drosophila: Gene Silencing of Alcohol dehydrogenase by white-Adh Transgenes Is Polycomb Dependent

1997 • 245 citations

Evidence that processed small dsRNAs may mediate sequence-specific mRNA degradation during RNAi in Drosophila embryos

2000 • 239 citations

Transgene and gene suppression: telling us something new?

1995 • 218 citations

pha-1, a selectable marker for gene transfer inC.elegans

1994 • 183 citations

RNA-directed RNA polymerase from tomato leaves. II. Catalytic in vitro properties

1993 • 152 citations

Distinct roles for RDE-1 and RDE-4 during RNA interference in Caenorhabditis elegans.

2001 • 151 citations

Identification and intracellular localization of the unc-22 gene product of Caenorhabditis elegans.

1988 • 145 citations

RNA-Dependent Replication and Transcription of Hepatitis Delta Virus RNA Involve Distinct Cellular RNA Polymerases

2000 • 128 citations

Additional sequence complexity in the muscle gene, unc-22, and its encoded protein, twitchin, of Caenorhabditis elegans.

1993 • 116 citations

RNA-directed RNA polymerase from tomato leaves. I. Purification and physical properties

1993 • 107 citations

Post-transcriptional gene-silencing: RNAs on the attack or on the defense?

2000 • 105 citations

RNA Interference Can Target Pre-mRNA: Consequences for Gene Expression in a Caenorhabditis elegans Operon

1999 • 105 citations

Specific HDV RNA-templated transcription by pol II in vitro

2000 • 94 citations

Cosuppression of Nonhomologous Transgenes in Drosophila Involves Mutually Related Endogenous Sequences

1999 • 88 citations

Complex Patterns of Alternative Splicing Mediate the Spatial and Temporal Distribution of Perlecan/UNC-52 inCaenorhabditis elegans

1999 • 87 citations

Subviral pathogens of plants: viroids and viroidlike satellite RNAs

1991 • 76 citations

Isolation of an RNA-Directed RNA Polymerase-Specific cDNA Clone from Tomato

1998 • 55 citations

A Vicious Cycle

2001 • 51 citations

DOMINANT X-CHROMOSOME NONDISJUNCTION MUTANTS OF CAENORHABDITIS ELEGANS

1982 • 44 citations

Transposon-induced deletions in unc-22 of C. elegans associated with almost normal gene activity

1988 • 38 citations

POST-TRANSCRIPTIONAL GENE SILENCING

2002 • 28 citations