Control of Autoimmune Diabetes in NOD Mice by GAD Expression or Suppression in β Cells

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

1990 • 1,955 citations

Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1985 • 1,292 citations

Insulin-Dependent Diabetes Mellitus

1996 • 1,171 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes.

1987 • 319 citations

Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes

1992 • 275 citations

64 000 Mr autoantibodies as predictors of insulin-dependent diabetes

1990 • 208 citations

Cellular and Molecular Mechanisms for the Initiation and Progression of β Cell Destruction Resulting from the Collaboration Between Macrophages and T Cells

1998 • 164 citations

[45] Production of transgenic mice

1993 • 161 citations

GAD-reactive CD4+ Th1 cells induce diabetes in NOD/SCID mice.

1998 • 160 citations

Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients.

1997 • 148 citations

Immunization With the Larger Isoform of Mouse Glutamic Acid Decarboxylase (GAD67) Prevents Autoimmune Diabetes in NOD Mice

1994 • 128 citations

Genetic differences in susceptibility of pancreatic β cells to virus-induced diabetes mellitus

1976 • 63 citations

Studies on Autoimmunity for T-Cell-Mediated β-Cell Destruction: Distinct Difference in β-Cell Destruction Between CD4+ and CD8+ T-Cell Clones Derived From Lymphocytes Infiltrating the Islets of NOD Mice

1992 • 60 citations

Long-term complications of virus-induced diabetes mellitus in mice

1982 • 57 citations

Localization of GAD-like immunoreactivity in the pancreas and stomach of the rat and mouse

1991 • 52 citations

The role of CD4 and CD8 T cells in type I diabetes in the NOD mouse

1997 • 49 citations

Prevention of autoimmune type I diabetes by CD4+ suppressor T cells in superantigen-treated non-obese diabetic mice.

1993 • 39 citations

PREVENTION OF RECURRENT DIABETES IN SYNGENIC ISLET-TRANSPLANTED NOD MICE BY TRANSFUSION OF AUTOREACTIVE T LYMPHOCYTES1

1994 • 10 citations

PREVENTION OF RECURRENT DIABETES IN SYNGENIC ISLET-TRANSPLANTED NOD MICE BY TRANSFUSION OF AUTOREACTIVE T LYMPHOCYTES1

1994 • 10 citations