Immature and Mature CD8α+ Dendritic Cells Prolong the Survival of Vascularized Heart Allografts

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation

1999 • 1,912 citations

Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

2000 • 1,577 citations

Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells

2001 • 1,384 citations

Improved technique of heart transplantation in rats

1969 • 1,338 citations

Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo

2000 • 1,286 citations

Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified.

1996 • 1,129 citations

Distinct dendritic cell subsets differentially regulate the class of immune responseinvivo

1999 • 1,013 citations

CD8α+ and CD8α− Subclasses of Dendritic Cells Direct the Development of Distinct T Helper Cells In Vivo

1999 • 998 citations

In Vivo Microbial Stimulation Induces Rapid CD40 Ligand–independent Production of Interleukin 12 by Dendritic Cells and their Redistribution to T Cell Areas

1997 • 937 citations

Cross-Presentation, Dendritic Cells, Tolerance and Immunity

2001 • 894 citations

CD4 and CD8 Expression by Dendritic Cell Subtypes in Mouse Thymus and Spleen

2000 • 812 citations

Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells.

1982 • 807 citations

Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.

1996 • 800 citations

A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.

1996 • 653 citations

The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells.

1992 • 642 citations

The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro.

1994 • 607 citations

Cutting Edge: Intravenous Soluble Antigen Is Presented to CD4 T Cells by CD8− Dendritic Cells, but Cross-Presented to CD8 T Cells by CD8+ Dendritic Cells

2001 • 584 citations

Localization of Distinct Peyer's Patch Dendritic Cell Subsets and Their Recruitment by Chemokines Macrophage Inflammatory Protein (Mip)-3α, Mip-3β, and Secondary Lymphoid Organ Chemokine

2000 • 578 citations

The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies.

1990 • 561 citations

Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells

2000 • 560 citations

Dendritic cell subtypes in mouse lymphoid organs: cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes.

1997 • 524 citations

Differential Production of IL-12, IFN-α, and IFN-γ by Mouse Dendritic Cell Subsets

2001 • 496 citations

Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survivalin vivo

2000 • 477 citations

Targeted Expression of Major Histocompatibility Complex (MHC) Class II Molecules Demonstrates that Dendritic Cells Can Induce Negative but Not Positive Selection of Thymocytes In Vivo

1997 • 459 citations

Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice.

1997 • 455 citations

Flt3-Ligand and Granulocyte Colony-Stimulating Factor Mobilize Distinct Human Dendritic Cell Subsets In Vivo

2000 • 419 citations

Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny.

1996 • 405 citations

Development of CD8α-Positive Dendritic Cells from a Common Myeloid Progenitor

2000 • 398 citations

In vivo generation of human dendritic cell subsets by Flt3 ligand

2000 • 397 citations

COSTIMULATORY MOLECULE-DEFICIENT DENDRITIC CELL PROGENITORS (MHC CLASS II+, CD80dim, CD86-) PROLONG CARDIAC ALLOGRAFT SURVIVAL IN NONIMMUNOSUPPRESSED RECIPIENTS12

1996 • 378 citations

Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch.

1996 • 360 citations

Interleukin 12–dependent Interferon γ Production by CD8α+Lymphoid Dendritic Cells

1999 • 340 citations

The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus

1989 • 318 citations

High Levels of a Major Histocompatibility Complex II–Self Peptide Complex on Dendritic Cells from the T Cell Areas of Lymph Nodes

1997 • 292 citations

Does T-cell tolerance require a dedicated antigen-presenting cell?

1989 • 288 citations

Dendritic Cells in Transplantation—Friend or Foe?

2001 • 282 citations

BONE MARROW-DERIVED DENDRITIC CELL PROGENITORS (NLDC 145+, MHC CLASS II+, B7-1dim, B7-2−) INDUCE ALLOANTIGEN-SPECIFIC HYPORESPONSIVENESS IN MURINE T LYMPHOCYTES1,2

1995 • 281 citations

Modulating the immune response with dendritic cells and their growth factors

2001 • 277 citations

Heterogeneity of Mouse Spleen Dendritic Cells: In Vivo Phagocytic Activity, Expression of Macrophage Markers, and Subpopulation Turnover

1998 • 261 citations

Fas ligand (CD95L) and B7 expression on dendritic cells provide counter-regulatory signals for T cell survival and proliferation.

1997 • 247 citations

A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production.

1996 • 238 citations

The control of T cell responses by dendritic cell subsets

2000 • 223 citations

BLOCKADE OF THE CD40-CD40 LIGAND PATHWAY POTENTIATES THE CAPACITY OF DONOR-DERIVED DENDRITIC CELL PROGENITORS TO INDUCE LONG-TERM CARDIAC ALLOGRAFT SURVIVAL1,2

1997 • 215 citations

Granulocyte/macrophage colony-stimulating factor-stimulated hepatic dendritic cell progenitors prolong pancreatic islet allograft survival.

1995 • 202 citations

Isolation and characterization of dendritic cells from mouse heart and kidney.

1994 • 179 citations

CD8+TCR+ and CD8+TCR− Cells in Whole Bone Marrow Facilitate the Engraftment of Hematopoietic Stem Cells across Allogeneic Barriers

1999 • 177 citations

The evolution of self-tolerance: a new cell arises to meet the challenge of self-reactivity

1998 • 175 citations

Antigen-driven induction of CD11c on intestinal intraepithelial lymphocytes and CD8+ T cells in vivo.

1995 • 171 citations

Antigen-pulsed CD8α+ Dendritic Cells Generate an Immune Response after Subcutaneous Injection without Homing to the Draining Lymph Node

1999 • 161 citations

Activation of Transplant Immunity: Effect of Donor Leukocytes on Thyroid Allograft Rejection

1976 • 159 citations

Designer dendritic cells for tolerance induction: guided not misguided missiles

2001 • 132 citations

Successful Allotransplantation of Mouse Pancreatic Islets to Nonimmunosuppressed Recipients

1980 • 124 citations

Culture of bone marrow cells in GM-CSF plus high doses of lipopolysaccharide generates exclusively immature dendritic cells which induce alloantigen- specific CD4 T cell anergyin vitro

2000 • 122 citations

SPLIT TOLERANCE INDUCED BY ORTHOTOPIC LIVER TRANSPLANTATION IN MICE1

1994 • 121 citations

IL-12 Induction by a Th1-Inducing Adjuvant In Vivo: Dendritic Cell Subsets and Regulation by IL-10

2001 • 111 citations

Concept of lymphoid versus myeloid dendritic cell lineages revisited: both CD8α− and CD8α+dendritic cells are generated from CD4lowlymphoid-committed precursors

2000 • 111 citations

Use of the fluorescence activated cell sorter to enrich dendritic cells from mouse spleen

1990 • 108 citations

Phenotypic and Functional Characterization of Mouse Hepatic CD8α+ Lymphoid-Related Dendritic Cells

2000 • 100 citations

Differentiation of myeloid dendritic cells into CD8α-positive dendritic cells in vivo

2000 • 98 citations

Liver-Derived DEC205+B220+CD19− Dendritic Cells Regulate T Cell Responses

2001 • 95 citations

INCREASED APOPTOSIS OF IMMUNOREACTIVE HOST CELLS AND AUGMENTED DONOR LEUKOCYTE CHIMERISM, NOT SUSTAINED INHIBITION OF B7 MOLECULE EXPRESSION ARE ASSOCIATED WITH PROLONGED CARDIAC ALLOGRAFT SURVIVAL IN MICE PRECONDITIONED WITH IMMATURE DONOR DENDRITIC CELLS PLUS ANTI-CD40L mAb1,2

1999 • 76 citations

CTL priming by CD8+ and CD8– dendritic cellsin vivo

1999 • 76 citations

CD40‐deficient dendritic cells producing interleukin‐10, but not interleukin‐12, induce T‐cell hyporesponsiveness in vitro and prevent acute allograft rejection

1999 • 69 citations

Deletion of high-avidity T cells by thymic epithelium.

1995 • 67 citations

IL-12 acts selectively on CD8 alpha- dendritic cells to enhance presentation of a tumor peptide in vivo.

1999 • 63 citations

CD8alpha(-) and CD8alpha(+) subclasses of dendritic cells undergo phenotypic and functional maturation in vitro and in vivo.

2001 • 60 citations

Langerhans cells acquire a CD8+ dendritic cell phenotype on maturation by CD40 ligation

2000 • 57 citations

IL-12 Acts Selectively on CD8α− Dendritic Cells to Enhance Presentation of a Tumor Peptide In Vivo

1999 • 53 citations

CD8α− and CD8α+ subclasses of dendritic cells undergo phenotypic and functional maturationin vitroandin vivo

2001 • 50 citations

In vivo generation of human dendritic cell subsets by Flt3 ligand

2000 • 44 citations

Viral IL-10-Induced Immunosuppression Requires Th2 Cytokines and Impairs APC Function Within the Allograft

2001 • 24 citations

RARE-EVENT ANALYSIS OF CIRCULATING HUMAN DENDRITIC CELL SUBSETS AND THEIR PRESUMPTIVE MOUSE COUNTERPARTS1

2001 • 22 citations

INABILITY OF DENDRITIC CELLS TO PREVENT THE BLOOD TRANSFUSION EFFECT IN A MOUSE CARDIAC ALLOGRAFT MODEL

1987 • 18 citations

Induction of Polyomavirus-Specific CD8⁺T Lymphocytes by Distinct Dendritic Cell Subpopulations

2001 • 14 citations

Differentiation of myeloid dendritic cells into CD8α-positive dendritic cells in vivo

2000 • 9 citations