Distinct mechanisms for the induction and maintenance of allograft tolerance with CTLA4-Fc treatment.

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

"Infectious" Transplantation Tolerance

1993 • 890 citations

Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo

1984 • 884 citations

AN IMPROVED METHOD FOR ISOLATION OF MOUSE PANCREATIC ISLETS

1985 • 548 citations

Immunobiology of Tissue Transplantation: A Return to the Passenger Leukocyte Concept

1983 • 524 citations

Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1.

1993 • 494 citations

Interferon gamma plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance.

1990 • 372 citations

CTLA4 mediates antigen-specific apoptosis of human T cells.

1995 • 331 citations

TRANSPLANTATION TOLERANCE INDUCED BY CTLA4-Ig1

1994 • 303 citations

Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action.

1990 • 302 citations

Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway.

1991 • 298 citations

Reentry of T cells to the adult thymus is restricted to activated T cells.

1991 • 263 citations

Administration of an anti-interleukin 2 receptor monoclonal antibody prolongs cardiac allograft survival in mice.

1985 • 194 citations

Islet Allograft Survival After a Single Course of Treatment of Recipient with Antibody to L3T4

1987 • 179 citations

T cell regulation in adult transplantation tolerance.

1996 • 144 citations

Complete blockade of B7 family-mediated costimulation is necessary to induce human alloantigen-specific anergy: a method to ameliorate graft- versus-host disease and extend the donor pool

1996 • 138 citations

EVIDENCE THAT LONG-TERM CARDIAC ALLOGRAFT SURVIVAL INDUCED BY ANTI-CD4 MONOCLONAL ANTIBODY DOES NOT REQUIRE DEPLETION OF CD4+ T CELLS

1992 • 82 citations

SUPPRESSOR T CELLS IN RATS WITH PROLONGED CARDIAC ALLOGRAFT SURVIVAL AFTER TREATMENT WITH CYCLOSPORINE1

1984 • 80 citations

Induction and reversal of long-lived specific unresponsiveness to a T-dependent antigen following CTLA4Ig treatment.

1995 • 70 citations

Monoclonal antibodies for the induction of transplantation tolerance

1993 • 29 citations

Two phenotypically distinct populations of T cells have suppressor capabilities simultaneously in the maintenance phase of immunologic enhancement.

1987 • 23 citations