Distinct Role of CD80 and CD86 in the Regulation of the Activation of B Cell and B Cell Lymphoma

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

1994 • 950 citations

Cloning of B7-2: a CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation

1993 • 911 citations

B70 antigen is a second ligand for CTLA-4 and CD28

1993 • 907 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

How B and T cells talk to each other

1994 • 659 citations

B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4

1995 • 577 citations

NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1999 • 526 citations

B7-1 and B7-2 Have Overlapping, Critical Roles in Immunoglobulin Class Switching and Germinal Center Formation

1997 • 499 citations

Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.

1995 • 481 citations

CD28/B7 Costimulation: A Review

1998 • 447 citations

Reversibility of T helper 1 and 2 populations is lost after long-term stimulation.

1996 • 437 citations

Expansion or Elimination of B Cells In Vivo: Dual Roles for CD40- and Fas (CD95)-Ligands Modulated by the B Cell Antigen Receptor

1996 • 405 citations

Differential costimulatory effects of adhesion molecules B7, ICAM-1, LFA-3, and VCAM-1 on resting and antigen-primed CD4+ T lymphocytes.

1992 • 395 citations

Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.

1993 • 357 citations

Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.

1995 • 323 citations

CD28-B7 interactions in T-cell activation

1994 • 315 citations

CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway.

1995 • 285 citations

Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2.

1994 • 262 citations

Structure and Dimerization of a Soluble Form of B7-1

2000 • 240 citations

Inhibition of human B-cell lymphoma growth by CD40 stimulation

1994 • 232 citations

Activation-induced cell death

2001 • 180 citations

Resting B lymphocytes can be triggered directly through the CDw40 (Bp50) antigen. A comparison with IL-4-mediated signaling.

1988 • 136 citations

Mice transgenic for a soluble form of murine CTLA-4 show enhanced expansion of antigen-specific CD4+ T cells and defective antibody production in vivo.

1994 • 132 citations

Tumor rejection requires a CTLA4 ligand provided by the host or expressed on the tumor: superiority of B7-1 over B7-2 for active tumor immunization.

1996 • 128 citations

CD86 (B7-2) on Human B Cells

1997 • 120 citations

Antitumor Effect of CD40 Ligand: Elicitation of Local and Systemic Antitumor Responses by IL-12 and B7

1998 • 90 citations

A negative regulatory function of B7 revealed in B7-1 transgenic mice

1994 • 82 citations

Rejection of MHC class II-transfected tumor cells requires induction of tumor-encoded B7-1 and/or B7-2 costimulatory molecules.

1996 • 73 citations

Antibodies to Murine CD40 Stimulate Normal B Lymphocytes but Inhibit Proliferation of B Lymphoma Cells

1993 • 67 citations

B Cell Receptor-Stimulated Mitochondrial Phospholipase A2 Activation and Resultant Disruption of Mitochondrial Membrane Potential Correlate with the Induction of Apoptosis in WEHI-231 B Cells

2001 • 59 citations

The baculovirus antiapoptotic p35 gene also functions via an oxidant-dependent pathway

1999 • 57 citations

CD40 and CD95 induce programmed cell death in the human myeloma cell line XG2

1997 • 45 citations

Identification of distinct domains in CD40 involved in B7-1 induction or growth inhibition.

1996 • 42 citations

Antigen receptor‐induced apoptosis of human germinal center B cells is targeted to a centrocytic subset

1997 • 40 citations

Transmembrane signaling through CD80 (B7-1) induces growth arrest and cell spreading of human B lymphocytes accompanied by protein tyrosine phosphorylation

1996 • 35 citations

Immunoglobulin fold characteristics of B7–1 (CD80) and B7–2 (CD86)

1994 • 33 citations

Subcellular localization of CD80 receptors is dependent on an intact cytoplasmic tail and is required for CD28-dependent T cell costimulation.

1996 • 32 citations

Bcl-2 and Bax expression and chlorambucil-induced apoptosis in the T-cells and leukaemic B-cells of untreated B-cell chronic lymphocytic leukaemia patients

2000 • 30 citations

Differential Effect of Anti-B7-1 and Anti-M150 Antibodies in Restricting the Delivery of Costimulatory Signals from B Cells and Macrophages

1998 • 29 citations

Invitro culturedSpodoptera frugiperda insect cells: Model for oxidative stress-induced apoptosis

1999 • 28 citations

Two Regions in the CD80 Cytoplasmic Tail Regulate CD80 Redistribution and T Cell Costimulation

1998 • 27 citations

A 150‐kDa molecule of macrophage membrane stimulates interleukin‐2 and interferon‐γ production and proliferation of ovalbumin‐specific CD4⁺ T cells

1994 • 16 citations