Evidence that Furin Is an Authentic Transforming Growth Factor-β1-Converting Enzyme

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

1985 • 1,687 citations

Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.

1983 • 1,613 citations

Expression and secretion of type beta transforming growth factor by activated human macrophages.

1987 • 981 citations

New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues.

1981 • 925 citations

MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

1996 • 855 citations

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

1998 • 789 citations

The Notch1 receptor is cleaved constitutively by a furin-like convertase

1998 • 720 citations

The proprotein convertases

1998 • 648 citations

Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.

1990 • 647 citations

Furin-dependent intracellular activation of the human stromelysin-3 zymogen

1995 • 620 citations

Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells.

1988 • 604 citations

Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway

1991 • 590 citations

PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.

1991 • 589 citations

Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gpl60

1992 • 572 citations

Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface.

1994 • 494 citations

Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis

1999 • 428 citations

Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2

1997 • 423 citations

Transforming growth factor beta (TGF-?) in inflammation: A cause and a cure

1992 • 417 citations

The family of subtilisin/kexin like pro-protein and pro-hormone convertases: Divergent or shared functions

1994 • 401 citations

A new type of transforming growth factor-beta, TGF-beta 3.

1988 • 396 citations

Processing of Transforming Growth Factor β1 Precursor by Human Furin Convertase

1995 • 395 citations

Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo.

1990 • 378 citations

Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases

1996 • 349 citations

Embryonic expression pattern of TGF beta type-1 RNA suggests both paracrine and autocrine mechanisms of action

1988 • 347 citations

Metalloprotease-Disintegrin MDC9: Intracellular Maturation and Catalytic Activity

1999 • 312 citations

Molecules in focus Transforming growth factor-beta (TGF-β)

1998 • 306 citations

Regulation of Bone Morphogenetic Protein Activity by Pro Domains and Proprotein Convertases

1999 • 301 citations

Transforming growth factor-β: pleiotropic role in the regulation of hematopoiesis

2000 • 298 citations

Blockade of type β transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat

1999 • 296 citations

Differential expression of TGF β1, β2 and β3 genes during mouse embryogenesis

1991 • 296 citations

Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin

1998 • 295 citations

Synergistic cooperation of TFE3 and Smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 gene

1998 • 288 citations

Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases

1996 • 286 citations

cDNA cloning by PCR of rat transforming growth factor β-1

1990 • 274 citations

Molecular events in the processing of recombinant type 1 pre-pro-transforming growth factor beta to the mature polypeptide.

1988 • 273 citations

Eukaryotic protein processing: endoproteolysis of precursor proteins

1997 • 271 citations

Identification of a Second Human Subtilisin-Like Protease Gene in thefes/fpsRegion of Chromosome 15

1991 • 268 citations

α ₁ -Antitrypsin Portland, a bioengineered serpin highly selective for furin: Application as an antipathogenic agent

1998 • 265 citations

Transforming Growth Factor β: Biochemistry and Roles in Embryogenesis, Tissue Repair and Remodeling, and Carcinogenesis

1988 • 255 citations

cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases.

1996 • 236 citations

BMP-4 is proteolytically activated by furin and/or PC6 during vertebrate embryonic development

1998 • 234 citations

Transforming growth factor-β: pleiotropic role in the regulation of hematopoiesis

2000 • 232 citations

Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells.

1990 • 219 citations

Specific binding to cultured cells of 125I-labeled type beta transforming growth factor from human platelets.

1984 • 212 citations

Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant.

1993 • 211 citations

Transforming Growth Factor-β2: cDNA Cloning and Sequence Analysis

1988 • 200 citations

Regulation of alveolar macrophage transforming growth factor-beta secretion by corticosteroids in bleomycin-induced pulmonary inflammation in the rat.

1993 • 185 citations

Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2

1993 • 182 citations

The autocrine production of transforming growth factor-beta 1 during lymphocyte activation. A study with a monoclonal antibody-based ELISA.

1990 • 169 citations

Intracellular Maturation of the Mouse Metalloprotease Disintegrin MDC15

1998 • 167 citations

Impaired fertility in mice deficient for the testicular germ-cell protease PC4

1997 • 157 citations

Distinct Patterns of Transforming Growth Factor-β Isoform and Receptor Expression in Human Atherosclerotic Lesions

1999 • 156 citations

The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments.

1996 • 150 citations

The developmental expression in rat of proteases furin, PC1, PC2, and carboxypeptidase E: implications for early maturation of proteolytic processing capacity

1994 • 146 citations

Cytokines in Kidney Disease: The Role of Transforming Growth Factor-β

1993 • 131 citations

TGFbeta1 regulates gene expression of its own converting enzyme furin.

1997 • 128 citations

Transforming Growth Factor

2008 • 121 citations

Endoproteolytic processing of integrin pro-α subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7

2000 • 104 citations

A Second Mutant Allele of Furin in the Processing-incompetent Cell Line, LoVo

1995 • 101 citations

Autoinduction of Transforming Growth Factor β1 Is Mediated by the AP-1 Complex

1990 • 99 citations

7B2 Is a Specific Intracellular Binding Protein of the Prohormone Convertase PC2

1995 • 97 citations

Inhibition of matrix metalloproteinase 2 maturation and HT1080 invasiveness by a synthetic furin inhibitor

1998 • 97 citations

Retention of the transforming growth factor-beta 1 precursor in the Golgi complex in a latent endoglycosidase H-sensitive form.

1992 • 92 citations

Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases

1996 • 91 citations

α1-Antitrypsin Portland Inhibits Processing of Precursors Mediated by Proprotein Convertases Primarily within the Constitutive Secretory Pathway

1997 • 88 citations

The neuroendocrine precursor 7B2 is a sulfated protein proteolytically processed by a ubiquitous furin-like convertase.

1994 • 86 citations

In Vitro Characterization of the Novel Proprotein Convertase PC7

1997 • 79 citations

The PC6B Cytoplasmic Domain Contains Two Acidic Clusters That Direct Sorting to Distincttrans-Golgi Network/Endosomal Compartments

2000 • 79 citations

Molecular Events in the Processing of Recombinant Type 1 Pre-Pro-Transforming Growth Factor Beta to the Mature Polypeptide

1988 • 78 citations

The role of eukaryotic subtilisin-like endoproteases for the activation of human immunodeficiency virus glycoproteins in natural host cells

1997 • 78 citations

Isolation of the human PC6 gene encoding the putative host protease for HIV-1 gp160 processing in CD4+ T lymphocytes.

1996 • 59 citations

Defective processing of the insulin receptor in an endoprotease-deficient Chinese hamster cell strain is corrected by expression of mouse furin.

1993 • 51 citations

Aggregating Human Platelets Stimulate the Expression of Thrombin Receptors in Cultured Vascular Smooth Muscle Cells via the Release of Transforming Growth Factor-β ₁ and Platelet-Derived Growth Factor _AB

1997 • 50 citations

Increased Expression of Transforming Growth Factor-β1 and Thrombospondin-1 in Congenital Hepatic Fibrosis: Possible Role of the Hepatic Stellate Cell

1999 • 49 citations

Furin and proprotein convertase 7 (PC7)/lymphoma PC endogenously expressed in rat liver can be resolved into distinct post-Golgi compartments

1998 • 39 citations

Sequence Requirements for Endoproteolytic Processing of Precursor Proteins by Fur in: Transfection and In Vitro Experiments1

1994 • 34 citations

Immunohistochemical study on transforming growth factor-beta1 expression in liver fibrosis of Down's syndrome with transient abnormal myelopoiesis

1999 • 32 citations

Enhanced TGFβ1 maturation in high five cells coinfected with recombinant baculovirus encoding the convertase furin/pace: Improved technology for the production of recombinant proproteins in insect cells

1998 • 31 citations

Purification of transforming growth factor beta 1 from human platelets.

1996 • 28 citations

TGF-β and Regulation ofInterstitial Nephritis

1998 • 15 citations

Deleted Work

1955 • 0 citations