The role of eukaryotic subtilisin-like endoproteases for the activation of human immunodeficiency virus glycoproteins in natural host cells

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

1984 • 3,530 citations

Mammalian subtilisins: The long-sought dibasic processing endoproteases

1991 • 756 citations

Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease.

1992 • 628 citations

Endoproteolytic cleavage of gp160 is required for the activation of human immunodeficiency virus

1988 • 608 citations

Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

1990 • 579 citations

Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gpl60

1992 • 572 citations

Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface.

1994 • 494 citations

Characterization of gp41 as the Transmembrane Protein Coded by the HTLV-III/LAV Envelope Gene

1985 • 442 citations

Detection of a fusion peptide sequence in the transmembrane protein of human immunodeficiency virus

1987 • 433 citations

Reduction of Background Problems in Nonradioactive Northern and Southern Blot Analyses Enables Higher Sensitivity Than 32P-Based Hybridizations

1993 • 407 citations

The family of subtilisin/kexin like pro-protein and pro-hormone convertases: Divergent or shared functions

1994 • 401 citations

Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo.

1990 • 378 citations

Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site.

1990 • 296 citations

Identification of a Second Human Subtilisin-Like Protease Gene in thefes/fpsRegion of Chromosome 15

1991 • 268 citations

Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease. Its testis-specific expression.

1992 • 249 citations

Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin.

1995 • 247 citations

The V3 Loops of the HIV-1 and HTV-2 Surface Glycoproteins Contain Proteolytic Cleavage Sites: A Possible Function in Viral Fusion?

1991 • 244 citations

cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases.

1996 • 236 citations

Proprotein-processing endoproteases PC6 and furin both activate hemagglutinin of virulent avian influenza viruses

1994 • 215 citations

Immunopathogenesis of HIV infection

1991 • 213 citations

Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant.

1993 • 211 citations

Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2

1990 • 202 citations

Identification and Functional Expression of a New Member of the Mammalian Kex2-Like Processing Endoprotease Family: Its Striking Structural Similarity to PACE41

1993 • 185 citations

Mutational analysis of the cleavage sequence of the human immunodeficiency virus type 1 envelope glycoprotein precursor gp160

1989 • 172 citations

Processing of viral glycoproteins by the subtilisin-like endoprotease furin and its inhibition by specific peptidylchloroalkylketones

1994 • 166 citations

Maturation of the trans-Golgi network protease furin: compartmentalization of propeptide removal, substrate cleavage, and COOH-terminal truncation.

1994 • 151 citations

Structure and function of eukaryotic proprotein processing enzymes of the subtilisin family of serine proteases.

1993 • 149 citations

Role of conserved glycosylation sites in maturation and transport of influenza A virus hemagglutinin

1993 • 142 citations

West African HIV-2-Related Human Retrovirus with Attenuated Cytopathicity

1988 • 141 citations

The convertases furin and PC1 can both cleave the human immunodeficiency virus (HIV)-1 envelope glycoprotein gp160 into gp120 (HIV-1 SU) and gp41 (HIV-I TM).

1994 • 135 citations

Mutational analysis of the human immunodeficiency virus type 1 env gene product proteolytic cleavage site

1990 • 131 citations

Mammalian subtilisin-related proteinases in cleavage activation of the paramyxovirus fusion glycoprotein: superiority of furin/PACE to PC2 or PC1/PC3

1992 • 129 citations

A Mutation of Furin Causes the Lack of Precursor-Processing Activity in Human Colon Carcinoma LoVo Cells

1993 • 125 citations

Identification of an isoform with an extremely large Cys‐rich region of PC6, a Kex2‐like processing endoprotease

1993 • 123 citations

Cytoplasmic domain truncation enhances fusion activity by the exterior glycoprotein complex of human immunodeficiency virus type 2 in selected cell types

1992 • 122 citations

Expression of mouse furin in a Chinese hamster cell resistant to Pseudomonas exotoxin A and viruses complements the genetic lesion.

1993 • 109 citations

Endoproteolytic Cleavage of Its Propeptide Is a Prerequisite for Efficient Transport of Furin Out of the Endoplasmic Reticulum

1995 • 108 citations

Sequence specificity of furin, a proprotein-processing endoprotease, for the hemagglutinin of a virulent avian influenza virus

1994 • 107 citations

A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas.

1996 • 102 citations

A Second Mutant Allele of Furin in the Processing-incompetent Cell Line, LoVo

1995 • 101 citations

Characterization of a Secreted Form of Human Furin Endoprotease

1993 • 91 citations

Assembly of SIV Virus-like Particles Containing Envelope Proteins Using a Baculovirus Expression System

1995 • 91 citations

Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases

1996 • 91 citations

Proteolytic processing of human cytomegalovirus glycoprotein B (gpUL55) is mediatedby the human endoprotease furin

1995 • 83 citations

PC8 [corrected], a new member of the convertase family

1996 • 82 citations

A furin-defective cell line is able to process correctly the gp160 of human immunodeficiency virus type 1

1994 • 82 citations

Proteolytic cleavage of wild type and mutants of the F protein of human parainfluenza virus type 3 by two subtilisin-like endoproteases, furin and Kex2

1994 • 81 citations

14 Activation Cleavage of Viral Spike Proteins by Host Proteases

1994 • 79 citations

Analysis of Protein Expression and Virus-like Particle Formation in Mammalian Cell Lines Stably Expressing HIV-1 gag and env Gene Products with or without Active HIV Proteinase

1993 • 78 citations

Requirement of N-terminal amino acid residues of gp41 for human immunodeficiency virus type 1-mediated cell fusion

1995 • 74 citations

Legitimate and illegitimate cleavage of human immunodeficiency virus glycoproteins by furin

1993 • 60 citations

Immunological analysis of human immunodeficiency virus type 1 envelope glycoprotein proteolytic cleavage

1992 • 50 citations

Processing protease for gp160 human immunodeficiency virus type I envelope glycoprotein precursor in human T4+ lymphocytes. Purification and characterization

1993 • 47 citations

Identification and characterization of fusion and processing domains of the human immunodeficiency virus type 2 envelope glycoprotein

1992 • 46 citations

Inhibition of proteolytic cleavage of the hemagglutinin of influenza virus by the calcium-specific ionophore A23187.

1984 • 46 citations

Effect of Mutations in the V3 Loop of HIV-1 gp120 on Infectivity and Susceptibility to Proteolytic Cleavage

1993 • 41 citations

Furin is important but not essential for the proteolytic maturation of gp160 of HIV‐1

1995 • 40 citations

Proprotein processing activity and cleavage site selectivity of the Kex2‐like endoprotease PACE4

1993 • 39 citations

C8, a new member of the convertase family

1996 • 39 citations

Biochemical and Genetic Definition of the Cellular Protease Required for HIV-1 gp160 Processing

1995 • 30 citations

Activation of an Influenza Virus A/Turkey/Oregon/71 HA Insertion Variant by the Subtilisin-like Endoprotease Furin

1994 • 24 citations

Correlation of proteolytic cleavage of F protein precursors in paramyxoviruses with expression of the fur, PACE4 and PC6 genes in mammalian cells

1994 • 20 citations

Calcium Requirement and Inhibitor Spectrum for Intracellular HIV Type 1 gp160 Processing in Cultured HeLa Cells and CD4+ Lymphocytes: Similarity to Those of Viral Envelope Glycoprotein Maturase1

1995 • 10 citations

Kex2p: a model for cellular endoprotease processing human immunodeficiency virus type 1 envelope glycoprotein precursor

1994 • 9 citations

T4-lymphocyte endoprotease responsible for the proteolytic processing of HIV-1 GP160, like Kex2p endoprotease, is a calcium-dependent enzyme

1994 • 4 citations