Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2

Molecular dissection of the secretory pathway

1992 • 985 citations

Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic

1991 • 832 citations

Mammalian subtilisins: The long-sought dibasic processing endoproteases

1991 • 756 citations

Protein degradation in the endoplasmic reticulum

1990 • 659 citations

Progress in Unraveling Pathways of Golgi Traffic

1985 • 615 citations

Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway

1991 • 590 citations

PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.

1991 • 589 citations

Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

1990 • 579 citations

New mammalian expression vectors

1990 • 525 citations

Cloning and Primary Sequence of a Mouse Candidate Prohormone Convertase PC1 Homologous to PC2, Furin, and Kex2: Distinct Chromosomal Localization and Messenger RNA Distribution in Brain and Pituitary Compared to PC2

1991 • 475 citations

Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.

1991 • 449 citations

Hepatoma secretory proteins migrate from rough endoplasmic reticulum to Golgi at characteristic rates

1983 • 436 citations

Oligomerization is essential for transport of vesicular stomatitis viral glycoprotein to the cell surface

1986 • 417 citations

Cloning, sequencing, and secretion of Bacillusamyloliquefacienssubtillisin inBacillus subtilis

1983 • 357 citations

Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes.

1991 • 317 citations

Identification of a Second Human Subtilisin-Like Protease Gene in thefes/fpsRegion of Chromosome 15

1991 • 268 citations

Tyrosine sulfation is a trans-Golgi-specific protein modification.

1987 • 261 citations

Distribution and regulation of the prohormone convertases PC1 and PC2 in the rat pituitary.

1992 • 256 citations

Identification of an intermediate compartment involved in protein transport from endoplasmic reticulum to Golgi apparatus.

1990 • 252 citations

Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease. Its testis-specific expression.

1992 • 249 citations

cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells.

1993 • 223 citations

Compartmentation of the Golgi complex: brefeldin-A distinguishes trans-Golgi cisternae from the trans-Golgi network.

1990 • 222 citations

Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells.

1990 • 219 citations

Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein.

1986 • 207 citations

Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase.

1992 • 203 citations

Peptide Biosynthesis and Processing

1991 • 155 citations

Proprotein conversion is determined by a multiplicity of factors including convertase processing, substrate specificity, and intracellular environment. Cell type-specific processing of human prorenin by the convertase PC1.

1992 • 149 citations

Proteases and posttranslational processing of prohormones: a review

1983 • 144 citations

fur gene expression as a discriminating marker for small cell and nonsmall cell lung carcinomas.

1987 • 144 citations

ATP-coupled transport of vesicular stomatitis virus G protein between the endoplasmic reticulum and the Golgi.

1986 • 141 citations

Temperature and energy dependence of secretory protein transport in the exocrine pancreas.

1986 • 140 citations

Biosynthesis of the prohormone convertase mPC1 in AtT-20 cells.

1992 • 128 citations

Posttranslational processing of the prohormone-cleaving Kex2 protease in the Saccharomyces cerevisiae secretory pathway.

1991 • 118 citations

Sequence requirements for precursor cleavage within the constitutive secretory pathway.

1992 • 113 citations

Secretion of functional papain precursor from insect cells. Requirement for N-glycosylation of the pro-region.

1990 • 101 citations

Enzymic characterization of murine and human prohormone convertase-1 (mPC1 and hPC1) expressed in mammalian GH4C1 cells

1993 • 98 citations

Mammalian Neural and Endocrine Pro-Protein and Pro-Hormone Convertases Belonging to the Subtilisin Family of Serine Proteinases

1991 • 96 citations

Regulation of PACE propeptide-processing activity: requirement for a post-endoplasmic reticulum compartment and autoproteolytic activation.

1992 • 93 citations

Concomitant synthesis of beta-endorphin and alpha-melanotropin from two forms of pro-opiomelanocortin in the rat pars intermedia.

1979 • 87 citations

Minireview: The New Eukaryotic Precursor Processing Proteinases

1991 • 84 citations

Analysis of sequence requirements for protein tyrosine sulfation

1993 • 70 citations

The post-translational processing and intracellular sorting of PC2 in the islets of Langerhans.

1992 • 67 citations

Biosynthesis of the mannose 6-phosphate recognition marker in transport-impaired mouse lymphoma cells. Demonstration of a two-step phosphorylation.

1988 • 65 citations

The pro‐region of the Kex2 endoprotease of Saccharomyces cerevisiae is removed by self‐processing

1992 • 53 citations

The cDNA Sequence of the Human Pro-Hormone and Pro-Protein Convertase PC1

1992 • 48 citations

Coordinate regulation of mRNA levels of pro-opiomelanocortin and the candidate processing enzymes PC2 and PC3, but not furin, in rat pituitary intermediate lobe

1991 • 40 citations

The cDNA structure of the porcine pro‐hormone convertase PC2 and the comparative processing by PC1 and PC2 of the N‐terminal glycopeptide segment of porcine POMC

1992 • 39 citations

Neuroanatomical and Functional Studies of Peptide Precursor-Processing Enyzmes

1991 • 24 citations

Differential subcellular distribution of PC1, PC2 and furin in bovine adrenal medulla and secretion of PC1 and PC2 from this tissue

1992 • 22 citations

The Prohormone and Proprotein Processing Enzymes PC1 and PC2: Structure, Selective Cleavage of Mouse POMC and Human Renin at Pairs of Basic Residues, Cellular Expression, Tissue Distribution, and mRNA Regulation

1992 • 21 citations

Evidence That Differentiates between Precursor Cleavages at Dibasic and Arg-X-Lys/Arg-Arg Sites1

1991 • 20 citations

A novel Kex2 enzyme can process the proregion of the yeast alpha-factor leader in the endoplasmic reticulum instead of in the Golgi

1992 • 11 citations