Impaired fertility in mice deficient for the testicular germ-cell protease PC4

Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice.

1991 • 1,358 citations

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

1987 • 1,231 citations

Gene Targeting: A Practical Approach

1994 • 592 citations

Mouse egg integrin α6β1functions as a sperm receptor

1995 • 472 citations

The family of subtilisin/kexin like pro-protein and pro-hormone convertases: Divergent or shared functions

1994 • 401 citations

Sperm from mice carrying a targeted mutation of the acrosin gene can penetrate the oocyte zona pellucida and effect fertilization.

1994 • 359 citations

Proteolytic Processing Mechanisms in the Biosynthesis of Neuroendocrine Peptides: The Subtilisin-like Proprotein Convertases

1995 • 348 citations

Distribution and regulation of the prohormone convertases PC1 and PC2 in the rat pituitary.

1992 • 256 citations

Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease. Its testis-specific expression.

1992 • 249 citations

cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases.

1996 • 236 citations

Differential Processing of Proglucagon by the Subtilisin-like Prohormone Convertases PC2 and PC3 to Generate either Glucagon or Glucagon-like Peptide

1995 • 228 citations

Altering Genes in Animals by Gene Targeting

1992 • 224 citations

Proteolytic processing of a protein involved in sperm-egg fusion correlates with acquisition of fertilization competence.

1990 • 219 citations

Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase.

1992 • 203 citations

Nerve growth factor mRNA and protein in the testis and epididymis of mouse and rat.

1988 • 200 citations

Effect of Sperm Lipid Peroxidation on Fertilization

1996 • 174 citations

Structure and function of eukaryotic proprotein processing enzymes of the subtilisin family of serine proteases.

1993 • 149 citations

[28] Application of LacZ gene fusions to postimplantation development

1993 • 125 citations

A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas.

1996 • 102 citations

Developmental expression of the prohormone convertases PC1 and PC2 in mouse pancreatic islets.

1994 • 87 citations

[13] Pro-protein convertases of subtilisin/kexin family

1994 • 87 citations

Distinct mRNA expression of the highly homologous convertases PC5 and PACE4 in the rat brain and pituitary

1995 • 83 citations

PC8 [corrected], a new member of the convertase family

1996 • 82 citations

Expression of pituitary adenylate cyclase activating polypeptide (PACAP) gene by rat spermatogenic cells

1995 • 70 citations

Cloning and analysis of monkey fertilin reveals novel α subunit isoforms

1995 • 64 citations

Proenkephalin products are stored in the sperm acrosome and may function in fertilization.

1990 • 51 citations

Localization of Kex2‐like processing endoproteases, furin and PC4, within mouse testis by in situ hybridization

1993 • 41 citations

Structure of the Gene for the Testis-Specific Proprotein Convertase 4 and of Its Alternate Messenger RNA Isoforms

1994 • 40 citations

C8, a new member of the convertase family

1996 • 39 citations

Proprotein convertases and the pathophysiology of human diseases: prospective considerations.

1995 • 33 citations

A novel peptide from the growth hormone releasing hormone gene stimulates Sertoli cell activity.

1996 • 29 citations

Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human

1995 • 25 citations

Effect of catalase and thioredoxin addition to sperm incubation medium before in vitro fertilization on sperm capacity to support embryo development

1996 • 23 citations

Surface Expression of the Pre-β Subunit of Fertilin Is Regulated at a Post-translational Level in Guinea Pig Spermatids

1995 • 20 citations

Calcium-induced aggregation of neuroendocrine protein 7B2in vitro and its modulation by ATP

1995 • 12 citations