Increased Expression of Transforming Growth Factor-β1 and Thrombospondin-1 in Congenital Hepatic Fibrosis: Possible Role of the Hepatic Stellate Cell

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

1987 • 1,243 citations

Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo

1998 • 1,151 citations

Hepatic lipocytes: the principal collagen-producing cells of normal rat liver.

1985 • 839 citations

Congenital diseases of intrahepatic bile ducts: Variations on the theme “ductal plate malformation”

1992 • 564 citations

Thrombospondin causes activation of latent transforming growth factor- beta secreted by endothelial cells by a novel mechanism [published erratum appears in J Cell Biol 1993 Sep;122(5):following 1143]

1993 • 467 citations

Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo.

1990 • 432 citations

In vitro and in vivo association of transforming growth factor-beta 1 with hepatic fibrosis.

1989 • 420 citations

Regulation of Transforming Growth Factor-β Activation by Discrete Sequences of Thrombospondin 1

1995 • 413 citations

Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor.

1990 • 407 citations

Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors.

1989 • 401 citations

Maintenance of Differentiated Phenotype of Cultured Rat Hepatic Lipocytes by Basement Membrane Matrix

1989 • 353 citations

Isolation and Properties of a Thrombin-sensitive Protein of Human Platelets

1972 • 306 citations

Alcoholic liver injury in baboons: transformation of lipocytes to transitional cells.

1984 • 299 citations

Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor β: Implication for a pathogenetic role in alcoholic liver fibrogenesis

1990 • 295 citations

Alcoholic liver injury in baboons: Transformation of lipocytes to transitional cells

1984 • 275 citations

Thrombospondin exerts an antiangiogenic effect on cord formation by endothelial cells in vitro.

1991 • 273 citations

Thrombospondin modulates focal adhesions in endothelial cells.

1989 • 271 citations

Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease.

1991 • 266 citations

The synthesis of proteoglycans in fat-storing cells of rat liver

1987 • 259 citations

Perisinusoidal fat-storing cells are the main vitamin A storage sites in rat liver

1985 • 259 citations

Transforming growth factor-beta complexes with thrombospondin.

1992 • 256 citations

5462925 Transforming growth factor beta2,3

1996 • 255 citations

Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblastlike cells. A potential mechanism of self perpetuation in liver fibrogenesis.

1992 • 230 citations

Cellular Sources of Noncollagenous Matrix Proteins: Role of Fat-Storing Cells in Fibrogenesis

1990 • 227 citations

Cytokines and cellular crosstalk involved in the activation of fat-storing cells.

1995 • 224 citations

Cellular Sources of Collagen and Regulation of Collagen Production in Liver

1990 • 197 citations

Ito–Cell Gene Expression and Collagen Regulation

1990 • 190 citations

Lipocytes and transitional cells in alcoholic liver disease: A morphometric study

1988 • 187 citations

Specific inhibition of endothelial cell proliferation by thrombospondin

1990 • 168 citations

What is congenital hepatic fibrosis?

1992 • 154 citations

Immunolocalization of laminin in normal rat liver and biosynthesis of laminin by hepatic lipocytes in primary culture

1988 • 141 citations

Regulation of TGFβ gene expression in rat liver intoxicated with carbon tetrachloride

1990 • 137 citations

Connective tissue biology and hepatic fibrosis: Report of a conference

1990 • 129 citations

Formation of extracellular matrix in normal rat liver: Lipocytes as a major source of proteoglycan

1988 • 120 citations

Renal and biliary abnormalities in a new murine model of autosomal recessive polycystic kidney disease

1993 • 120 citations

Liver fibrosis and extracellular matrix

1989 • 94 citations

Congenital Hepatic Fibrosis-Is it a Single Clinical Entity?

1973 • 68 citations

Liver transplantation: Viral hepatitis

1995 • 59 citations

Localization of thrombospondin in hepatocellular carcinoma

1997 • 21 citations