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2011 • 55,498 citations

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2012 • 11,574 citations

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2012 • 7,361 citations

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2008 • 4,838 citations

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2002 • 4,625 citations

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2011 • 4,371 citations

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1982 • 2,957 citations

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2002 • 2,879 citations

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2010 • 2,721 citations

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1996 • 1,473 citations

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2007 • 1,317 citations

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2011 • 913 citations

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2007 • 843 citations

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1995 • 827 citations

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2003 • 816 citations

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2009 • 812 citations

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2009 • 770 citations

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2005 • 758 citations

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2009 • 694 citations

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2004 • 664 citations

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2010 • 632 citations

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2010 • 554 citations

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2001 • 467 citations

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2006 • 447 citations

Evaluating the yield of medical tests

1982 • 331 citations

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2010 • 323 citations

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2023 • 210 citations

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2012 • 165 citations

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2009 • 87 citations

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2012 • 85 citations

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2010 • 34 citations