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Recognizing and reversing the immunosuppressive tumor microenvironment of head and neck cancer

Data up to Jan 2025

Published2012
Citations68
References94

Total Citations Per Year

Abstract

References (94)

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

2010 • 14,016 citations

Cancer-related inflammation

2008 • 10,288 citations

Myeloid-derived suppressor cells as regulators of the immune system

2009 • 6,165 citations

Microenvironmental regulation of metastasis

2008 • 3,476 citations

Regulatory T Cells: Mechanisms of Differentiation and Function

2007 • 2,574 citations

Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis

2007 • 2,155 citations

The role of myeloid cells in the promotion of tumour angiogenesis

2008 • 1,574 citations

Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis

2004 • 1,111 citations

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

2010 • 1,030 citations

TUMOR STROMA AND REGULATION OF CANCER DEVELOPMENT

2006 • 972 citations

Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein

2008 • 865 citations

Antigen-Specific Inhibition of CD8+ T Cell Response by Immature Myeloid Cells in Cancer Is Mediated by Reactive Oxygen Species

2004 • 825 citations

Oral Squamous Cell Carcinoma

2005 • 750 citations

TP53Mutations and Survival in Squamous-Cell Carcinoma of the Head and Neck

2007 • 732 citations

Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function

2006 • 726 citations

Prostaglandin E2 Promotes Tumor Progression by Inducing Myeloid-Derived Suppressor Cells

2007 • 718 citations

Clinical significance of defective dendritic cell differentiation in cancer.

2000 • 694 citations

Myeloid-Derived Suppressor Cells Promote Cross-Tolerance in B-Cell Lymphoma by Expanding Regulatory T Cells

2008 • 640 citations

Bv8 regulates myeloid-cell-dependent tumour angiogenesis

2007 • 614 citations

Prognostic Value of Tumor-Infiltrating CD4+ T-Cell Subpopulations in Head and Neck Cancers

2006 • 561 citations

Human papillomavirus-associated head and neck cancer is a distinct epidemiologic, clinical, and molecular entity

2004 • 544 citations

The Novel Role of Tyrosine Kinase Inhibitor in the Reversal of Immune Suppression and Modulation of Tumor Microenvironment for Immune-Based Cancer Therapies

2009 • 522 citations

Identification of a CD11b+/Gr-1+/CD31+ myeloid progenitor capable of activating or suppressing CD8+T cells

2000 • 516 citations

Transforming growth factor-β in cancer and metastasis

2006 • 500 citations

Arginase, Prostaglandins, and Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma

2007 • 466 citations

Reduction of Myeloid-Derived Suppressor Cells and Induction of M1 Macrophages Facilitate the Rejection of Established Metastatic Disease

2005 • 462 citations

Spontaneous apoptosis of circulating T lymphocytes in patients with head and neck cancer and its clinical importance.

2002 • 375 citations

Treatment of Vulvar Intraepithelial Neoplasia with Topical Imiquimod

2008 • 372 citations

Macrophage infiltration and its prognostic implications in breast cancer: The relationship with VEGF expression and microvessel density

2005 • 363 citations

Gr-1+CD11b+ Myeloid Cells Tip the Balance of Immune Protection to Tumor Promotion in the Premetastatic Lung

2010 • 357 citations

Tumor associated macrophages in human prostate cancer: relation to clinicopathological variables and survival.

2000 • 339 citations

Identification and functional analysis of tumor-infiltrating plasmacytoid dendritic cells in head and neck cancer.

2003 • 332 citations

Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function

2007 • 309 citations

Regulation of Dendritic Cell Differentiation and Antitumor Immune Response in Cancer by Pharmacologic-Selective Inhibition of the Janus-Activated Kinase 2/Signal Transducers and Activators of Transcription 3 Pathway

2005 • 308 citations

Immunomodulatory effects of cyclophosphamide and implementations for vaccine design

2011 • 295 citations

Immune Checkpoint Proteins: A New Therapeutic Paradigm for Cancer—Preclinical Background: CTLA-4 and PD-1 Blockade

2010 • 293 citations

The Frequency and Suppressor Function of CD4+CD25highFoxp3+ T Cells in the Circulation of Patients with Squamous Cell Carcinoma of the Head and Neck

2007 • 273 citations

Defects in the Human Leukocyte Antigen Class I Antigen Processing Machinery in Head and Neck Squamous Cell Carcinoma: Association with Clinical Outcome

2005 • 247 citations

The multifaceted relationship between IL-10 and adaptive immunity: putting together the pieces of a puzzle

2003 • 243 citations

Galectin-1: A Link Between Tumor Hypoxia and Tumor Immune Privilege

2005 • 236 citations

Vaccination with HPV16 peptides of patients with advanced cervical carcinoma: clinical evaluation of a phase I–II trial

1999 • 231 citations

Tumor-Derived G-CSF Facilitates Neoplastic Growth through a Granulocytic Myeloid-Derived Suppressor Cell-Dependent Mechanism

2011 • 231 citations

Bv8 and endocrine gland-derived vascular endothelial growth factor stimulate hematopoiesis and hematopoietic cell mobilization

2004 • 221 citations

Signaling abnormalities, apoptosis, and reduced proliferation of circulating and tumor-infiltrating lymphocytes in patients with oral carcinoma.

2002 • 214 citations

Therapeutic human papillomavirus vaccines: current clinical trials and future directions

2008 • 188 citations

Effect of reduced immunosuppression after kidney transplant failure on risk of cancer: population based retrospective cohort study

2010 • 171 citations

Phase II Study of Sunitinib in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck: GORTEC 2006-01

2009 • 170 citations

Tumor-Associated Macrophage Infiltration in Pulmonary Adenocarcinoma: Association with Angiogenesis and Poor Prognosis

1999 • 160 citations

T Regulatory Type 1 Cells in Squamous Cell Carcinoma of the Head and Neck: Mechanisms of Suppression and Expansion in Advanced Disease

2008 • 156 citations

Spontaneous human squamous cell carcinomas are killed by a human cytotoxic T lymphocyte clone recognizing a wild-type p53-derived peptide

1996 • 155 citations

Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation

2011 • 155 citations

Treatment of recurrent squamous cell carcinoma of the head and neck with low doses of lnterleukin-2 injected periiymphatically

1988 • 151 citations

Increased Prevalence of Dysplastic and Malignant Lip Lesions in Renal-Transplant Recipients

1995 • 150 citations

Tumor-infiltrating lymphocytes, particularly the balance between CD8+ T cells and CCR4+ regulatory T cells, affect the survival of patients with oral squamous cell carcinoma

2010 • 133 citations

Chemoprevention by cyclooxygenase-2 inhibition reduces immature myeloid suppressor cell expansion

2006 • 132 citations

Lymphocyte subpopulations infiltrating squamous carcinomas of the head and neck: Correlations with extent of tumor and prognosis

1986 • 126 citations

Co-signaling molecules of the B7-CD28 family in positive and negative regulation of T lymphocyte responses

2004 • 115 citations

A phase II study of Hsp-7 (SGN-00101) in women with high-grade cervical intraepithelial neoplasia

2007 • 113 citations

Human Leukocyte Antigen (HLA) Class I Defects in Head and Neck Cancer: Molecular Mechanisms and Clinical Significance

2005 • 108 citations

Phase I Study of Gefitinib Plus Celecoxib in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

2005 • 104 citations

Predominant expression of B7-H1 and its immunoregulatory roles in oral squamous cell carcinoma

2005 • 100 citations

Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in head and neck cancers.

2008 • 100 citations

Treatment of vulvar intraepithelial neoplasia with topical imiquimod: Seven years median follow-up of a randomized clinical trial

2011 • 98 citations

11q13 amplification status and human papillomavirus in relation to p16 expression defines two distinct etiologies of head and neck tumours

2006 • 94 citations

Generation of anti-p53 cytotoxic T lymphocytes from human peripheral blood using autologous dendritic cells.

1999 • 94 citations

Generation of T Cells Specific for the Wild-Type Sequence p53264–272 Peptide in Cancer Patients: Implications for Immunoselection of Epitope Loss Variants

2000 • 92 citations

Cyclin D1 and p16 alterations in advanced premalignant lesions of the upper aerodigestive tract: role in response to chemoprevention and cancer development.

2001 • 88 citations

Phase 1 study of concurrent sunitinib and image‐guided radiotherapy followed by maintenance sunitinib for patients with oligometastases

2009 • 88 citations

HPV-induced oropharyngeal cancer, immune response and response to therapy

2009 • 80 citations

Phase II study of sunitinib malate in head and neck squamous cell carcinoma

2009 • 80 citations

Enhanced programmed death 1 (PD-1) and PD-1 ligand (PD-L1) expression in patients with actinic cheilitis and oral squamous cell carcinoma

2011 • 76 citations

Regulatory T cells and their prognostic value for patients with squamous cell carcinoma of the head and neck

2009 • 66 citations

A phase II study of sunitinib in patients with recurrent and/or metastatic non-nasopharyngeal head and neck cancer

2009 • 61 citations

p53-Based Immunotherapy of Cancer

1998 • 61 citations

Phase 1 trial of concurrent erlotinib, celecoxib, and reirradiation for recurrent head and neck cancer

2011 • 59 citations

Possible prognostic value of histopathologic parameters in patients with carcinoma of the oral tongue

1998 • 58 citations

Human Papillomavirus Vaccines for Cervical Cancer

1999 • 49 citations

Role of cytokines in head and neck squamous cell carcinoma

2006 • 48 citations

Prognostic Significance of Tumor-Infiltrating Lymphocytes in Oropharyngeal Cancer

2007 • 48 citations

Antiproliferative Effects of Cytokines on Squamous Cell Carcinoma

1991 • 46 citations

Clinical and Immunopathological Results of a Phase II Study of Perilymphatically Injected Recombinant Interleukin-2 in Locally Far Advanced, Nonpretreated Head and Neck Squamous Cell Carcinoma

1991 • 45 citations

Validation of Genetic Sequence Variants as Prognostic Factors in Early-Stage Head and Neck Squamous Cell Cancer Survival

2011 • 44 citations

Head and Neck Squamous Cell Carcinoma: New Translational Therapies

2010 • 43 citations

T Cell-Tumor Interaction Directs the Development of Immunotherapies in Head and Neck Cancer

2010 • 38 citations

Association of T-cell regulatory gene polymorphisms with oral squamous cell carcinoma

2010 • 36 citations

Immunological Effects of Multikinase Inhibitors for Kidney Cancer: A Clue for Integration with Cellular Therapies?

2011 • 36 citations

Molecular and Clinicopathologic Comparisons of Head and Neck Squamous Carcinoma Variants

2004 • 35 citations

Intratumor genomic heterogeneity correlates with histological grade of advanced oral squamous cell carcinoma

2006 • 33 citations

An MVA vaccine overcomes tolerance to human p53 in mice and humans

2007 • 27 citations

Ifosfamide in the Treatment of Head and Neck Cancer

2003 • 21 citations

Neo-adjuvant chemo-(immuno-)therapy of advanced squamous-cell head and neck carcinoma: a multicenter, phase III, randomized study comparing cisplatin + 5-fluorouracil (5-FU) with cisplatin + 5-FU + recombinant interleukin 2

1998 • 21 citations

The Efficacy of Imiquimod on Dysplastic Lesions of the Oral Mucosa: An Experimental Model

2010 • 19 citations

Expression of the T Cell Receptor αβ on a CD123+ BDCA2+ HLA-DR+ Subpopulation in Head and Neck Squamous Cell Carcinoma

2011 • 4 citations

Observations on preprofessional education: is there a "major" difference?

1991 • 1 citations

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Recognizing and reversing the immunosuppressive tumor microenvironment of head and neck… (2012) – Immunologic Research | Metascience Observatory Explorer