Cactus protein degradation mediates Drosophila dorsal-ventral signaling.

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

Drosophila: A laboratory handbook

1990 • 1,742 citations

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor

1988 • 1,200 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

Drosophila: a laboratory manual

1990 • 1,081 citations

The Toll gene of drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

1988 • 1,077 citations

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.

1993 • 1,047 citations

IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System

1993 • 967 citations

The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors.

1993 • 819 citations

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.

1994 • 723 citations

Establishment of dorsal-ventral polarity in the Drosophila embryo: Genetic studies on the role of the Toll gene product

1985 • 675 citations

A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo

1989 • 652 citations

Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel

1987 • 485 citations

NF-κB and related proteins: Rel/dorsal homologies meet ankyrin-like repeats

1992 • 415 citations

Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-κB subunit

1992 • 399 citations

Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.

1991 • 324 citations

The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo

1994 • 321 citations

I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding.

1992 • 252 citations

Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa B.

1995 • 243 citations

cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates

1992 • 243 citations

Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins

1992 • 230 citations

Localized enhancement and repression of the activity of the TGF-P family member, decapentaplegic, is necessary for dorsal-ventral pattern formation in the Drosophila embryo

1992 • 222 citations

pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo

1993 • 210 citations

Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B.

1994 • 209 citations

cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos

1991 • 187 citations

The role of easter, an apparent serine protease, in organizing the dorsal-ventral pattern of the Drosophila embryo

1989 • 175 citations

PEST sequences are signals for rapid intracellular proteolysis.

1990 • 166 citations

A processed form of the Spätzle protein defines dorsal-ventral polarity in the Drosophila embryo

1994 • 161 citations

Dissociation of the dorsal-cactus complex and phosphorylation of the dorsal protein correlate with the nuclear localization of dorsal.

1993 • 127 citations

Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo

1994 • 120 citations

Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity.

1991 • 113 citations

Dorsal, a Drosophila Rel-like protein, is phosphorylated upon activation of the transmembrane protein Toll.

1994 • 103 citations

Genetic characterization of tube and pelle, genes required for signaling between Toll and dorsal in the specification of the dorsal-ventral pattern of the Drosophila embryo.

1993 • 79 citations

Dominant and recessive alleles of the Drosophila easter gene are point mutations at conserved sites in the serine protease catalytic domain

1990 • 54 citations