Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic β-cells

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Role of calcium ions in regulation of mammalian intramitochondrial metabolism

1990 • 1,369 citations

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.

1992 • 1,128 citations

Electrophysiology of the pancreatic β-cell

1989 • 1,123 citations

Decoding of cytosolic calcium oscillations in the mitochondria

1995 • 1,090 citations

Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin

1992 • 920 citations

A Practical Guide to the Preparation of Ca2+ Buffers

1994 • 753 citations

A Lesson in Metabolic Regulation Inspired by the Glucokinase Glucose Sensor Paradigm

1996 • 728 citations

Mitochondrial calcium transport: physiological and pathological relevance

1994 • 702 citations

Are the β-Cell Signaling Molecules Malonyl-CoA and Cystolic Long-Chain Acyl-CoA Implicated in Multiple Tissue Defects of Obesity and NIDDM?

1996 • 466 citations

On the role of the calcium transport cycle in heart and other mammalian mitochondria

1980 • 375 citations

Relation between mitochondrial calcium transport and control of energy metabolism

1985 • 362 citations

Transfected Aequorin in the Measurement of Cytosolic Ca2+ Concentration ([Ca2+]c)

1995 • 361 citations

Evidence That Vesicles on the Synaptic Ribbon of Retinal Bipolar Neurons Can Be Rapidly Released

1996 • 297 citations

Co-localization of L-type Ca2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells.

1995 • 294 citations

Mitochondria and Diabetes: Genetic, Biochemical, and Clinical Implications of the Cellular Energy Circuit

1996 • 282 citations

Single islet beta-cell stimulation by nutrients: relationship between pyridine nucleotides, cytosolic Ca2+ and secretion.

1990 • 265 citations

Mechanisms by which glucose can control insulin release independently from its action on adenosine triphosphate-sensitive K+ channels in mouse B cells.

1993 • 265 citations

Subcellular imaging of intramitochondrial Ca2+ with recombinant targeted aequorin: significance for the regulation of pyruvate dehydrogenase activity.

1996 • 247 citations

New insights into pancreatic β-cell metabolic signaling in insulin secretion

1996 • 197 citations

Dynamic pacing of cell metabolism by intracellular Ca2+ transients.

1994 • 185 citations

A role for the mitochondrial Na(+)-Ca2+ exchanger in the regulation of oxidative phosphorylation in isolated heart mitochondria.

1993 • 159 citations

Maternally inherited diabetes and deafness: a new diabetes subtype

1996 • 158 citations

Mitochondrial DNA Is Required for Regulation of Glucose-stimulated Insulin Secretion in a Mouse Pancreatic Beta Cell Line, MIN6

1996 • 148 citations

Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane channels in pancreatic β-cells

1993 • 147 citations

Effect of disruption of actin filaments by Clostridium botulinum C2 toxin on insulin secretion in HIT-T15 cells and pancreatic islets.

1994 • 145 citations

Cytoplasmic Ca2+ oscillations in pancreatic ß-cells

1992 • 145 citations

Glucose-stimulated insulin secretion correlates with changes in mitochondrial and cytosolic Ca2+ in aequorin-expressing INS-1 cells.

1996 • 144 citations

Dehydrogenase activation by Ca2+ in cells and tissues

1991 • 131 citations

Temporal patterns of changes in ATP/ADP ratio, glucose 6-phosphate and cytoplasmic free Ca2+ in glucose-stimulated pancreatic β-cells

1996 • 121 citations

Video imaging of cytosolic Ca2+ in pancreatic beta-cells stimulated by glucose, carbachol, and ATP.

1992 • 118 citations

Activation of Stimulus-Secretion Coupling in Pancreatic β-Cells by Specific Products of Glucose Metabolism

1996 • 104 citations

Regulation of pancreatic β-cell mitochondrial metabolism: influence of Ca2+, substrate and ADP

1996 • 84 citations

Calcium Activation of Mitochondrial Glycerol Phosphate Dehydrogenase Restudied

1996 • 84 citations

The other human genome: Mitochondrial DNA and disease

1996 • 81 citations

Content of CoA-Esters in Perifused Rat Islets Stimulated by Glucose and Other Fuels

1991 • 79 citations

Glucose-induced activation of pyruvate dehydrogenase in isolated rat pancreatic islets

1990 • 70 citations

Glyceraldehyde Phosphate and Methyl Esters of Succinic Acid: Two “New” Potent Insulin Secretagogues

1988 • 65 citations

Dynamics of Ca2+ and guanosine 5′-[γ-thio]triphosphate action on insulin secretion from α-toxin-permeabilized HIT-T15 cells

1994 • 49 citations

Staphylococcus aureus alpha-toxin. Production of functionally intact, site-specifically modifiable protein by introduction of cysteine at positions 69, 130, and 186

1993 • 44 citations

Insulinotropic Action of Methyl Pyruvate: Enzymatic and Metabolic Aspects

1996 • 39 citations

Glycerol 3-phosphate-induced ATP production in intact mitochondria from pancreatic B-cells

1995 • 34 citations

Insulin secretion from islets of GK rats is not impaired after energy generating steps

1995 • 15 citations

Subcellular imaging of intramitochondrial Ca2+ with recombinant targeted aequorin

1996 • 5 citations