The hormonal regulation of pyruvate dehydrogenase complex

The insulin signaling system.

1994 • 1,733 citations

Role of calcium ions in regulation of mammalian intramitochondrial metabolism

1990 • 1,369 citations

Microdomains with High Ca ²⁺ Close to IP ₃ -Sensitive Channels that Are Sensed by Neighboring Mitochondria

1993 • 1,167 citations

Decoding of cytosolic calcium oscillations in the mitochondria

1995 • 1,090 citations

Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin

1992 • 920 citations

Raf meets Ras: completing the framework of a signal transduction pathway

1994 • 591 citations

Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase

1972 • 519 citations

The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex

1979 • 431 citations

Calcium ions and the regulation of NAD+-linked isocitrate dehydrogenase from the mitochondria of rat heart and other tissues

1978 • 359 citations

The mammalian pyruvate dehydrogenase complex: Structure and regulation

1983 • 336 citations

Fuel selection in animals

1986 • 313 citations

Ca2+ As a Second Messenger within Mitochondria of the Heart and other Tissues

1990 • 297 citations

Measurement of mitochondrial free Ca2+ concentration in living single rat cardiac myocytes

1991 • 277 citations

Subcellular imaging of intramitochondrial Ca2+ with recombinant targeted aequorin: significance for the regulation of pyruvate dehydrogenase activity.

1996 • 247 citations

Rat liver insulin mediator which stimulates pyruvate dehydrogenase phosphatase contains galactosamine and D-chiroinositol

1988 • 202 citations

Stimulated Ca2+ influx raises mitochondrial free Ca2+ to supramicromolar levels in a pancreatic beta-cell line. Possible role in glucose and agonist-induced insulin secretion.

1993 • 182 citations

Regulation of pyruvate metabolism in mammalian tissues.

1979 • 166 citations

Role of Ca2+ ions in the regulation of intramitochondrial metabolism in rat heart. Evidence from studies with isolated mitochondria that adrenaline activates the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes by increasing the intramitochondrial concentration of Ca2+

1984 • 151 citations

Insulin Generates an Enzyme Modulator from Hepatic Plasma Membranes: Regulation of Adenosine 3′, 5′-Monophosphate Phosphodiesterase, Pyruvate Dehydrogenase, and Adenylate Cyclase*

1987 • 142 citations

Does Mitogen-Activated-Protein Kinase have a Role in Insulin Action?. The Cases for and Against

1995 • 125 citations

Regulation of NAD+-linked isocitrate dehydrogenase and 2-oxoglutarate dehydrogenase by Ca2+ ions within toluene-permeabilized rat heart mitochondria. Interactions with regulation by adenine nucleotides and NADH/NAD+ ratios

1988 • 124 citations

Ruthenium Red inhibits the activation of pyruvate dehydrogenase caused by positive inotropic agents in the perfused rat heart

1983 • 119 citations

Multiple signalling pathways involved in the stimulation of fatty acid and glycogen synthesis by insulin in rat epididymal fat cells

1995 • 110 citations

Does Mitogen‐Activated‐Protein Kinase have a Role in Insulin Action?

1995 • 107 citations

Molecular cloning and expression of the catalytic subunit of bovine pyruvate dehydrogenase phosphatase and sequence similarity with protein phosphatase 2C

1993 • 98 citations

Metabolic fuel selection: general integration at the whole-body level

1995 • 93 citations

Direct evidence for a role of intramitochondrial Ca2+ in the regulation of oxidative phosphorylation in the stimulated rat heart. Studies using31P n.m.r. and ruthenium red

1989 • 84 citations

Towards the molecular basis for the regulation of mitochondrial dehydrogenases by calcium ions

1995 • 79 citations

Use of toluene-permeabilized mitochondria to study the regulation of adipose tissue pyruvate dehydrogenase in situ. Further evidence that insulin acts through stimulation of pyruvate dehydrogenase phosphate phosphatase

1986 • 74 citations

3 Pyruvate Dehydrogenase

1987 • 69 citations

The α-adrenergic-mediated activation of the cardiac mitochondrial Ca2+ uniporter and its role in the control of intramitochondrial Ca2+in vivo

1983 • 68 citations

Incorporation of 32Pi into pyruvate dehydrogenase phosphate in mitochondria from control and insulin-treated adipose tissue

1976 • 63 citations

Studies into the Mechanism Whereby Insulin Activates Pyruvate Dehydrogenase Complex in Adipose Tissue^a

1989 • 38 citations

Effects of Ca2+ and Mg2+ on the activity of pyruvate dehydrogenase phosphate phosphatase within toluene-permeabilized mitochondria

1987 • 37 citations

Persistence of the effect of insulin on pyruvate dehydrogenase activity in rat white and brown adipose tissue during the preparation and subsequent incubation of mitochondria

1984 • 36 citations

Signal Transduction by Intramitochondrial Ca2+ in Mammalian Energy Metabolism

1994 • 35 citations

The loading of fura-2 into mitochondria in the intact perfused rat heart and its use to estimate matrix Ca2+ under various conditions

1992 • 32 citations

The pyruvate dehydrogenase complex: nutrient control and the pathogenesis of insulin resistance.

1995 • 28 citations

Regulation of pyruvate dehydrogenase by insulin and polyamines within electropermeabilized fat-cells and isolated mitochondria

1992 • 19 citations

Effects of insulin and guanosine 5′-[γ-thio]triphosphate on fatty acid synthesis and lipolysis within electropermeabilized fat-cells

1992 • 17 citations

The Role of Ca²⁺ in the Hormonal Regulation of the Activities of Pyruvate Dehydrogenase and Oxoglutarate Dehydrogenase Complexes^a

1989 • 14 citations