Interaction of Smad Complexes with Tripartite DNA-binding Sites

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

Transcriptional Activators of TGF-β Responses: Smads

1998 • 1,024 citations

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1997 • 1,023 citations

SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

1998 • 952 citations

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

1998 • 916 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

1996 • 855 citations

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

1998 • 789 citations

MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

1996 • 710 citations

Crystal Structure of a Smad MH1 Domain Bound to DNA

1998 • 709 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

A human Mad protein acting as a BMP-regulated transcriptional activator

1996 • 674 citations

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.

1997 • 569 citations

Smad4 and FAST-1 in the assembly of activin-responsive factor

1997 • 567 citations

Identification and Functional Characterization of a Smad Binding Element (SBE) in the JunB Promoter That Acts as a Transforming Growth Factor-β, Activin, and Bone Morphogenetic Protein-inducible Enhancer

1998 • 562 citations

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.

1996 • 528 citations

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation

1998 • 527 citations

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

1997 • 524 citations

Smad2 and Smad3 Positively and Negatively Regulate TGFβ-Dependent Transcription through the Forkhead DNA-Binding Protein FAST2

1998 • 513 citations

Smads and early developmental signaling by the TGFβ superfamily

1998 • 485 citations

POU domain family values: flexibility, partnerships, and developmental codes.

1997 • 481 citations

A structural basis for mutational inactivation of the tumour suppressor Smad4

1997 • 459 citations

Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes

1997 • 439 citations

Stable binding of Drosophila heat shock factor to head-to-head and tail-to-tail repeats of a conserved 5 bp recognition unit

1989 • 439 citations

Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily

1996 • 432 citations

Trimerization of a yeast transcriptional activator via a coiled-coil motif

1989 • 392 citations

Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.

1994 • 377 citations

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4

1997 • 365 citations

Determinants of specificity in TGF-β signal transduction

1998 • 364 citations

A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway.

1996 • 351 citations

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function

1997 • 317 citations

Synergistic cooperation of TFE3 and Smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 gene

1998 • 288 citations

Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors

1998 • 281 citations

Tumor Suppressor Smad4 Is a Transforming Growth Factor β-Inducible DNA Binding Protein

1997 • 275 citations

Cellular interpretation of multiple TGF-β signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads

1997 • 260 citations

Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to theDrosophila mesoderm

1998 • 250 citations

Characterization of Human FAST-1, a TGFβ and Activin Signal Transducer

1998 • 230 citations

The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila

1998 • 218 citations

Heteromeric and Homomeric Interactions Correlate with Signaling Activity and Functional Cooperativity of Smad3 and Smad4/DPC4

1997 • 207 citations

The Drosophila Activin receptor Baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development

1999 • 190 citations

Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor

1996 • 172 citations

Molecular interactions between Vestigial and Scalloped promote wing formation in Drosophila

1998 • 161 citations

Smad4/DPC4 and Smad3 Mediate Transforming Growth Factor-β (TGF-β) Signaling through Direct Binding to a Novel TGF-β-responsive Element in the Human Plasminogen Activator Inhibitor-1 Promoter

1998 • 138 citations

Xenopus Smad8 acts downstream of BMP-4 to modulate its activity during vertebrate embryonic patterning

1998 • 129 citations

A CREB-binding site as a target for decapentaplegic signalling during Drosophila endoderm induction

1997 • 129 citations

Smad-dependent Transcriptional Activation of Human Type VII Collagen Gene (COL7A1) Promoter by Transforming Growth Factor-β

1998 • 118 citations

TGF-β signaling, Smads, and tumor suppressors

1998 • 100 citations

Functional intertwining of Dpp and EGFR signaling during Drosophilaendoderm induction

1998 • 95 citations

Intracellular signaling of osteogenic protein-1 through Smad5 activation

1998 • 86 citations

The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation

1997 • 72 citations

Drosophila glial architecture and development: analysis using a collection of new cell-specific markers

1993 • 43 citations

Identification of a NovelDrosophilaSMAD on the X Chromosome

1998 • 28 citations