The neuron–glia signal β‐neuregulin promotes Schwann cell motility via the MAPK pathway

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Growth of a rat neuroblastoma cell line in serum-free supplemented medium.

1979 • 2,285 citations

Multiple essential functions of neuregulin in development

1995 • 1,236 citations

Identification of Heregulin, a Specific Activator of p185 ^erbB2

1992 • 963 citations

Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system

1993 • 744 citations

Severe neuropathies in mice with targeted mutations in the ErbB3 receptor

1997 • 721 citations

Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin.

1994 • 649 citations

Regulation of protein kinase C ζ by PI 3-kinase and PDK-1

1998 • 612 citations

ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family

1993 • 612 citations

A neu acquaintance for ErbB3 and ErbB4: A role for receptor heterodimerization in growth signaling

1994 • 601 citations

Isolation of the NeuHER-2 stimulatory ligand: A 44 kd glycoprotein that induces differentiation of mammary tumor cells

1992 • 534 citations

A monoclonal antibody modulates the interaction of nerve growth factor with PC12 cells.

1984 • 503 citations

Glial growth factor restricts mammalian neural crest stem cells to a glial fate

1994 • 496 citations

Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat schwann cell precursors

1995 • 449 citations

Heregulin induces tyrosine phosphorylation of HER4/p180erbB4

1993 • 445 citations

GGF/Neuregulin Is a Neuronal Signal That Promotes the Proliferation and Survival and Inhibits the Differentiation of Oligodendrocyte Progenitors

1996 • 374 citations

Axonal Interactions Regulate Schwann Cell Apoptosis in Developing Peripheral Nerve: Neuregulin Receptors and the Role of Neuregulins

1996 • 321 citations

Rescue of the Cardiac Defect in ErbB2 Mutant Mice Reveals Essential Roles of ErbB2 in Peripheral Nervous System Development

1999 • 321 citations

Nerve growth factor and its low-affinity receptor promote Schwann cell migration.

1994 • 319 citations

Schwann cells and their precursors emerge as major regulators of nerve development

1999 • 302 citations

Heregulin Regulates Cytoskeletal Reorganization and Cell Migration through the p21-activated Kinase-1 via Phosphatidylinositol-3 Kinase

1998 • 288 citations

Schwann cell apoptosis at developing neuromuscular junctions is regulated by glial growth factor

1996 • 283 citations

Neuregulin, a factor with many functions in the life of a Schwann cell

2000 • 282 citations

ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoforms.

1994 • 273 citations

Axon-induced mitogenesis of human Schwann cells involves heregulin and p185erbB2.

1995 • 273 citations

Response of Schwann Cells to Action Potentials in Development

2000 • 267 citations

Schwann cell growth factors

1978 • 254 citations

Studies on cultured rat Schwann cells

1979 • 250 citations

Identification and purification of glial growth factor

1984 • 243 citations

Cell death in the Schwann cell lineage and its regulation by neuregulin.

1996 • 237 citations

Neuregulins in Development

1996 • 229 citations

Differential expression of ARIA isoforms in the rat brain

1995 • 229 citations

Axonal Regulation of Schwann Cell Proliferation and Survival and the Initial Events of Myelination Requires PI 3-Kinase Activity

2000 • 224 citations

Neu Differentiation Factor Activation of ErbB-3 and ErbB-4 Is Cell Specific and Displays a Differential Requirement for ErbB-2

1995 • 187 citations

Distinct isoforms of neuregulin are expressed in mesenchymal and neuronal cells during mouse development.

1994 • 180 citations

Glial Growth Factor 2, a Soluble Neuregulin, Directly Increases Schwann Cell Motility and Indirectly Promotes Neurite Outgrowth

1996 • 178 citations

Neuregulins and their receptors

1995 • 178 citations

Role of neuregulins in glial cell development

2000 • 175 citations

Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function

1998 • 173 citations

Axonal Neuregulin Signals Cells of the Oligodendrocyte Lineage through Activation of HER4 and Schwann Cells through HER2 and HER3

1997 • 172 citations

Fibronectin promotes rat Schwann cell growth and motility.

1982 • 164 citations

Studies on cultured rat Schwann cells. III. Assays for peripheral myelin proteins

1980 • 144 citations

Division of Labor of Schwann Cell Integrins during Migration on Peripheral Nerve Extracellular Matrix Ligands

1997 • 142 citations

Heregulin Stimulates Mitogenesis and Phosphatidylinositol 3-Kinase in Mouse Fibroblasts Transfected with erbB2/neu and erbB3

1995 • 141 citations

Gö 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low-level-producing reservoir cells in vitro.

1993 • 138 citations

ARIA/HRG regulates AChR epsilon subunit gene expression at the neuromuscular synapse via activation of phosphatidylinositol 3-kinase and Ras/MAPK pathway.

1996 • 131 citations

Detection of ERK activation by a novel monoclonal antibody

1997 • 131 citations

Heregulin-stimulated acetylcholine receptor gene expression in muscle: requirement for MAP kinase and evidence for a parallel inhibitory pathway independent of electrical activity

1997 • 130 citations

Schwann cell development in embryonic mouse nerves

1999 • 128 citations

Neuregulins and neuregulin receptors in neural development

1997 • 120 citations

Schwann cells: early lineage, regulation of proliferation and control of myelin formation

1992 • 119 citations

Negative regulation of the P o gene in Schwann cells: suppression of Po mRNA and protein induction in cultured Schwann cells by FGF2 and TGFβ1, TGFβ2 and TGFβ3

1994 • 117 citations

cAMP-dependent protein kinase A is required for Schwann cell growth: Interactions between the cAMP and neuregulin/tyrosine kinase pathways

1997 • 112 citations

Synergistic Regulation of Schwann Cell Proliferation by Heregulin and Forskolin

1998 • 103 citations

Involvement of Ras and Ral in Chemotactic Migration of Skeletal Myoblasts

2000 • 103 citations

PI 3-Kinase-Dependent and Independent Chemotaxis of Human Neutrophil Leukocytes

1995 • 99 citations

Schwann Cells Express NDF and SMDF/n-ARIA mRNAs, Secrete Neuregulin, and Show Constitutive Activation of erbB3 Receptors: Evidence for a Neuregulin Autocrine Loop

1997 • 85 citations

The phosphatidylinositol 3-kinase inhibitor wortmannin markedly reduces chemotactic peptide-induced locomotion and increases in cytoskeletal actin in human neutrophils

1997 • 81 citations

GTPases and phosphatidylinositol 3-kinase are critical for insulin-like growth factor-I-mediated Schwann cell motility.

2000 • 80 citations

Cultured neonatal schwann cells contain and secrete neuregulins

1996 • 74 citations

Platelet-derived growth factor-BB (PDGF-BB) regulation of migration and focal adhesion kinase phosphorylation in rabbit aortic vascular smooth muscle cells: roles of phosphatidylinositol 3-kinase and mitogen-activated protein kinases

1999 • 73 citations

Response of Schwann cells to mitogens in vitro is determined by pre-exposure to serum, time in vitro, and developmental age

1997 • 63 citations

Mr 42,000 ARIA: A Protein That May Regulate the Accumulation of Acetylcholine Receptors at Developing Chick Neuromuscular Junctions

1990 • 60 citations

Differential Regulation of Focal Adhesion Kinase and Mitogen‐Activated Protein Kinase Tyrosine Phosphorylation During Insulin‐Like Growth Factor‐I‐Mediated Cytoskeletal Reorganization

1998 • 57 citations

The Neuron-Glia Signal β Neuregulin Induces Sustained CREB Phosphorylation on Ser-133 in Cultured Rat Schwann Cells

1998 • 46 citations

The BM88 Antigen, a Novel Neuron-specific Molecule, Enhances the Differentiation of Mouse Neuroblastoma Cells

1995 • 29 citations

Endopeptidase-24.11 is suppressed in myelin-forming but not in non-myelin-forming schwann cells during development of the rat sciatic nerve

1992 • 27 citations

Involvement of protein kinase C in the proliferation of cultured Schwann cells

1993 • 25 citations