Nitric Oxide-Dependent Production of cGMP Supports the Survival of Rat Embryonic Motor Neurons Cultured with Brain-Derived Neurotrophic Factor

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Caspases: killer proteases

1997 • 2,440 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Glutamate, nitric oxide and cell-cell signalling in the nervous system

1991 • 2,406 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Nitric Oxide Signaling in the Central Nervous System

1995 • 1,628 citations

GDNF: a Potent Survival Factor for Motoneurons Present in Peripheral Nerve and Muscle

1994 • 1,261 citations

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

1997 • 1,241 citations

Extensive Nitration of Protein Tyrosines in Human Atherosclerosis Detected by Immunohistochemistry

1994 • 1,138 citations

Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.

1995 • 1,102 citations

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

1993 • 1,024 citations

Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes

1994 • 1,005 citations

Oxidative Damage and Tyrosine Nitration from Peroxynitrite

1996 • 990 citations

(S)NO Signals: Translocation, Regulation, and a Consensus Motif

1997 • 680 citations

Endothelial Nitric Oxide Synthase Targeting to Caveolae

1996 • 670 citations

Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: implications for synaptic plasticity.

1994 • 658 citations

Early Stages of Motor Neuron Differentiation Revealed by Expression of Homeobox Gene Islet-1

1992 • 638 citations

Neurotrophins promote motor neuron survival and are present in embryonic limb bud

1993 • 619 citations

An immunohistochemical study of the nerve growth factor receptor in developing rats

1988 • 610 citations

Reciprocal Regulation of Endothelial Nitric-oxide Synthase by Ca2+-Calmodulin and Caveolin

1997 • 610 citations

Evidence of neuronal oxidative damage in Alzheimer's disease.

1996 • 602 citations

Nitric Oxide in the Nervous System

1995 • 503 citations

A monoclonal antibody modulates the interaction of nerve growth factor with PC12 cells.

1984 • 503 citations

Nitric oxide triggers a switch to growth arrest during differentiation of neuronal cells

1995 • 484 citations

The double-edged role of nitric oxide in brain function and superoxide-mediated injury.

1991 • 471 citations

Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP

1994 • 467 citations

Endothelial NOS and the Blockade of LTP by NOS Inhibitors in Mice Lacking Neuronal NOS

1994 • 422 citations

Nitric Oxide and Superoxide Contribute to Motor Neuron Apoptosis Induced by Trophic Factor Deprivation

1998 • 342 citations

Peptide inhibitors of the ice protease family arrest programmed cell death of motoneurons in vivo and in vitro

1995 • 324 citations

Endothelial Nitric-oxide Synthase

1996 • 322 citations

A Role for Endothelial NO Synthase in LTP Revealed by Adenovirus-Mediated Inhibition and Rescue

1996 • 304 citations

Endothelial nitric oxide synthase. N-terminal myristoylation determines subcellular localization.

1993 • 275 citations

Members of several gene families influence survival of rat motoneurons in vitro and in vivo

1993 • 274 citations

Expression of Nitric-Oxide Synthase (NOS) in Injured CNS Neurons as Shown by NADPH Diaphorase Histochemistry

1993 • 268 citations

Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway

1996 • 267 citations

Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase

1995 • 267 citations

Induction of nitrotyrosine-like immunoreactivity in the lower motor neuron of amyotrophic lateral sclerosis

1995 • 266 citations

The Golgi Association of Endothelial Nitric Oxide Synthase Is Necessary for the Efficient Synthesis of Nitric Oxide

1995 • 257 citations

Agonist-modulated Palmitoylation of Endothelial Nitric Oxide Synthase

1995 • 220 citations

Cardiotrophin-1, a Cytokine Present in Embryonic Muscle, Supports Long-Term Survival of Spinal Motoneurons

1996 • 218 citations

Prolonged in vivo hypoxia enhances nitric oxide synthase type I and type III gene expression in adult rat lung.

1995 • 207 citations

Inhibition of nitric oxide synthase reduces motoneuron death due to spinal root avulsion

1993 • 206 citations

Trophic Support of Cultured Spiral Ganglion Neurons by Depolarization Exceeds and Is Additive with that by Neurotrophins or cAMP and Requires Elevation of [Ca²⁺]_iwithin a Set Range

1997 • 193 citations

Brain-derived neurotrophic factor promotes axonal regeneration and long-term survival of adult rat spinal motoneurons in vivo

1997 • 186 citations

Brain-derived neurotrophic factor promotes survival and blocks nitric oxide synthase expression in adult rat spinal motoneurons after ventral root avulsion

1995 • 175 citations

Nitric oxide delays the death of trophic factor-deprived PC12 cells and sympathetic neurons by a cGMP-mediated mechanism

1996 • 171 citations

Upregulation of protein-tyrosine nitration in the anterior horn cells of amyotrophic lateral sclerosis

1997 • 169 citations

Regulation of Neuronal Nitric Oxide Synthase through Alternative Transcripts

1997 • 159 citations

Colocalization of NOS and SOD1 in neurofilament accumulation within motor neurons of amyotrophic lateral sclerosis: an immunohistochemical study

1996 • 157 citations

Vicious Cycle Involving Na⁺Channels, Glutamate Release, and NMDA Receptors Mediates Delayed Neurodegeneration through Nitric Oxide Formation

1996 • 154 citations

Heme-dependent activation of soluble guanylate cyclase by nitric oxide: regulation of enzyme activity by porphyrins and metalloporphyrins.

1989 • 128 citations

Role of SOD-1 and nitric oxide/cyclic GMP cascade on neurofilament aggregation in ALS/MND

1996 • 118 citations

Nitric oxide and cGMP can produce either synaptic depression or potentiation depending on the frequency of presynaptic stimulation in the hippocampus

1994 • 114 citations

Molecular evidence for nitric oxide-mediated motor neuron development

1993 • 111 citations

Nitric oxide-mediated neuronal injury in multiple sclerosis

1992 • 90 citations

Cross-activation: overriding cAMP/cGMP selectivities of protein kinases in tissues

1992 • 75 citations

Activation of calcium-dependent potassium channels in rat brain neurons by neurotrophin-3 and nerve growth factor

1997 • 65 citations

Prevention of natural motoneurone cell death by dibutyryl cyclic GMP

1984 • 60 citations

Direct Measurement of Dilute Nitric Oxide in Solution with an Ozone Chemiluminescent Detector

1995 • 52 citations

Both p140 and p75NGFR Nerve Growth Factor Receptors Mediate Nerve Growth Factor-stimulated Calcium Uptake

1997 • 29 citations

Nitric Oxide Toxicity in Neuronal Injury and Degeneration

2000 • 18 citations

Posttranslational modifications of endothelial nitric oxide synthase

1996 • 12 citations

cGMP accumulation by spinal cord neurons during the period of neuromuscular junction formation

1982 • 10 citations

Nitric Oxide Toxicity in Neuronal Injury and Degeneration

1995 • 10 citations