Signaling events underlying thrombus formation

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Identification of the platelet ADP receptor targeted by antithrombotic drugs

2001 • 1,411 citations

Initiation of Platelet Adhesion by Arrest onto Fibrinogen or Translocation on von Willebrand Factor

1996 • 1,178 citations

Blood-borne tissue factor: Another view of thrombosis

1999 • 982 citations

A dual thrombin receptor system for platelet activation

1998 • 972 citations

Platelets and shear stress

1996 • 871 citations

Specific Synergy of Multiple Substrate–Receptor Interactions in Platelet Thrombus Formation under Flow

1998 • 809 citations

Cloning and characterization of human protease-activated receptor 4

1998 • 807 citations

Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin

1999 • 802 citations

Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse

2002 • 647 citations

The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress.

1991 • 619 citations

How the protease thrombin talks to cells

1999 • 574 citations

Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen

2001 • 545 citations

A mouse model of severe von Willebrand disease: Defects in hemostasis and thrombosis

1998 • 512 citations

Role of thrombin signalling in platelets in haemostasis and thrombosis

2001 • 505 citations

Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen

2000 • 490 citations

The Fc receptor γ-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen

1997 • 456 citations

G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets.

1994 • 441 citations

ADP Receptors of Platelets and their Inhibition

2001 • 422 citations

Biochemical mechanisms of platelet activation

1989 • 370 citations

Mechanisms Initiating Platelet Thrombus Formation

1997 • 368 citations

Effect of shear rate on platelet interaction with subendothelium in citrated and native blood. I. Shear rate--dependent decrease of adhesion in von Willebrand's disease and the Bernard-Soulier syndrome.

1978 • 368 citations

Shear-induced platelet aggregation can be mediated by vWF released from platelets, as well as by exogenous large or unusually large vWF multimers, requires adenosine diphosphate, and is resistant to aspirin

1988 • 365 citations

Activation of G12/G13 Results in Shape Change and Rho/Rho-Kinase–mediated Myosin Light Chain Phosphorylation in Mouse Platelets

1999 • 359 citations

Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor.

1994 • 357 citations

A revised model of platelet aggregation

2000 • 349 citations

Biochemical mechanisms of platelet activation

1989 • 328 citations

Biphasic Kinetics of Activation and Signaling for PAR1 and PAR4 Thrombin Receptors in Platelets

2000 • 296 citations

Platelet Collagen Receptors

2001 • 295 citations

Distinct mechanisms of platelet aggregation as a consequence of different shearing flow conditions.

1998 • 286 citations

The Vascular Biology of the Glycoprotein Ib-IX-V Complex

2001 • 281 citations

von Willebrand factor binding to platelet GpIb initiates signals for platelet activation.

1991 • 280 citations

Real-time analysis of shear-dependent thrombus formation and its blockade by inhibitors of von Willebrand factor binding to platelets

1993 • 271 citations

Contribution of Distinct Adhesive Interactions to Platelet Aggregation in Flowing Blood

1999 • 267 citations

Fibrinogen-independent platelet adhesion and thrombus formation on subendothelium mediated by glycoprotein IIb-IIIa complex at high shear rate.

1989 • 260 citations

Shear stress-induced von Willebrand factor binding to platelet glycoprotein Ib initiates calcium influx associated with aggregation

1992 • 256 citations

The role of platelet membrane glycoproteins Ib and IIb-IIIa in platelet adherence to human artery subendothelium

1986 • 237 citations

Protease-activated Receptors 1 and 4 Are Shut Off with Distinct Kinetics after Activation by Thrombin

2000 • 236 citations

Expression and Function of the Mouse Collagen Receptor Glycoprotein VI Is Strictly Dependent on Its Association with the FcRγ Chain

2000 • 229 citations

Protease-activated Receptors in Vascular Biology

2001 • 227 citations

Role of factor VIII-von Willebrand factor and fibronectin in the interaction of platelets in flowing blood with monomeric and fibrillar human collagen types I and III.

1985 • 225 citations

Plasma fibronectin promotes thrombus growth and stability in injured arterioles

2003 • 222 citations

Shear stress-induced von Willebrand factor binding to platelet glycoprotein Ib initiates calcium influx associated with aggregation

1992 • 218 citations

Structure-Function Analysis of Protease-activated Receptor 4 Tethered Ligand Peptides

2000 • 205 citations

Protection against thrombosis in mice lacking PAR3

2002 • 192 citations

An in vivo model of experimental arterial stenosis, intimal damage, and periodic thrombosis.

1991 • 179 citations

Intercellular calcium communication regulates platelet aggregation and thrombus growth

2003 • 178 citations

Distinct Glycoprotein Ib/V/IX and Integrin αIIbβ3-dependent Calcium Signals Cooperatively Regulate Platelet Adhesion under Flow

2002 • 175 citations

Sequential cytoplasmic calcium signals in a 2-stage platelet activation process induced by the glycoprotein Ibα mechanoreceptor

2002 • 174 citations

Fetal hemorrhage and platelet dysfunction in SLP-76–deficient mice

1999 • 174 citations

A thrombin receptor function for platelet glycoprotein Ib–IX unmasked by cleavage of glycoprotein V

2001 • 168 citations

Glycoprotein Ib-V-IX, a Receptor for von Willebrand Factor, Couples Physically and Functionally to the Fc Receptor γ-Chain, Fyn, and Lyn to Activate Human Platelets

1999 • 159 citations

Adaptor proteins in lymphocyte antigen-receptor signaling

1998 • 155 citations

Activation of Syk protein tyrosine kinase through interaction with integrin β cytoplasmic domains

2001 • 154 citations

Analysis of platelet adhesion to a collagen-coated surface under flow conditions: the involvement of glycoprotein VI in the platelet adhesion

1996 • 153 citations

Factor VIII/von Willebrand factor in subendothelium mediates platelet adhesion

1985 • 152 citations

Blockade of adenosine diphosphate receptors P2Y12 and P2Y1 is required to inhibit platelet aggregation in whole blood under flow

2001 • 150 citations

Physical Proximity and Functional Interplay of the Glycoprotein Ib-IX-V Complex and the Fc Receptor FcγRIIA on the Platelet Plasma Membrane

1998 • 149 citations

Intravenous nitroglycerin infusion inhibits cyclic blood flow responses caused by periodic platelet thrombus formation in stenosed canine coronary arteries.

1991 • 146 citations

The Role of ITAM- and ITIM-coupled Receptors in Platelet Activation by Collagen

2001 • 134 citations

Binding of Purified 14-3-3 ζ Signaling Protein to Discrete Amino Acid Sequences within the Cytoplasmic Domain of the Platelet Membrane Glycoprotein Ib-IX-V Complex

1998 • 134 citations

Adhesion receptor activation of phosphatidylinositol 3-kinase. von Willebrand factor stimulates the cytoskeletal association and activation of phosphatidylinositol 3-kinase and pp60c-src in human platelets.

1994 • 133 citations

Analysis of the Roles of 14-3-3 in the Platelet Glycoprotein Ib-IX–Mediated Activation of Integrin αIIbβ3 Using a Reconstituted Mammalian Cell Expression Model

1999 • 132 citations

Mathematical analysis of mural thrombogenesis. Concentration profiles of platelet-activating agents and effects of viscous shear flow

1989 • 132 citations

β3 Tyrosine Phosphorylation in αIIbβ3 (Platelet Membrane GP IIb-IIIa) Outside-in Integrin Signaling

2001 • 129 citations

Lymphocytes with a complex: adapter proteins in antigen receptor signaling

2000 • 127 citations

Role of Fc receptor γ-chain in platelet glycoprotein Ib–mediated signaling

2001 • 126 citations

Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin αIIbβ3

2002 • 124 citations

Role of ADP Receptor P2Y₁₂in Platelet Adhesion and Thrombus Formation in Flowing Blood

2002 • 122 citations

Endogenous prostacyclin contributes to the efficacy of a thromboxane synthetase inhibitor for preventing coronary artery thrombosis.

1981 • 120 citations

A collagen-related peptide regulates phospholipase Cγ2 via phosphatidylinositol 3-kinase in human platelets

1999 • 118 citations

The von Willebrand Factor-Glycoprotein Ib/V/IX Interaction Induces Actin Polymerization and Cytoskeletal Reorganization in Rolling Platelets and Glycoprotein Ib/V/IX-transfected Cells

1999 • 118 citations

Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3ζ

2000 • 116 citations

Collagen Receptor Signaling in Platelets and Megakaryocytes

1999 • 115 citations

Factor VIII/von Willebrand factor in subendothelium mediates platelet adhesion

1985 • 112 citations

Association of a phospholipase A2 (14-3-3 protein) with the platelet glycoprotein Ib-IX complex

1994 • 112 citations

Real-Time Analysis of Mural Thrombus Formation in Various Platelet Aggregation Disorders: Distinct Shear-Dependent Roles of Platelet Receptors and Adhesive Proteins Under Flow

1999 • 107 citations

Binding of factor VIII-von Willebrand factor to human arterial subendothelium precedes increased platelet adhesion and enhances platelet spreading.

1981 • 106 citations

Synergistic Adhesive Interactions and Signaling Mechanisms Operating between Platelet Glycoprotein Ib/IX and Integrin αIIbβ3

2000 • 106 citations

Platelet adhesion to fibronectin in flow: dependence on surface concentration and shear rate, role of platelet membrane glycoproteins GP IIb/IIIa and VLA-5, and inhibition by heparin

1994 • 101 citations

Interaction of calmodulin with the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex

2001 • 101 citations

Platelet signal transduction defect with Gα subunit dysfunction and diminished Gα _q in a patient with abnormal platelet responses

1997 • 98 citations

Adapter proteins in lymphocyte antigen-receptor signaling

2000 • 95 citations

The Cytoplasmic Domain of the α-Subunit of Glycoprotein (GP) Ib Mediates Attachment of the Entire GP Ib-IX Complex to the Cytoskeleton and Regulates von Willebrand Factor-induced Changes in Cell Morphology

1996 • 94 citations

Characteristics of shear-induced aggregation in whole blood.

1984 • 92 citations

Identification of Shc as the Primary Protein Binding to the Tyrosine-phosphorylated β3 Subunit of αIIbβ3 during Outside-in Integrin Platelet Signaling

2000 • 92 citations

Increased Shear Stress Overcomes the Antithrombotic Platelet Inhibitory Effect of Aspirin in Stenosed Dog Coronary Arteries

1996 • 90 citations

Glycoprotein Ib-von Willebrand Factor Interactions Activate Tyrosine Kinases in Human Platelets

1997 • 85 citations

Culprit lesion morphology and stenosis severity in the prediction of reocclusion after coronary thrombolysis: Angiographic results of the APRICOT study

1993 • 83 citations

Interaction between von Willebrand factor and glycoprotein Ib activates Src kinase in human platelets: role of phosphoinositide 3–kinase

2003 • 80 citations

Shear-stress-induced von Willebrand factor binding to platelets causes the activation of tyrosine kinase(s)

1994 • 77 citations

Platelet adhesion to fibronectin in flow: the importance of von Willebrand factor and glycoprotein Ib

1995 • 77 citations

Platelet Activation by von Willebrand Factor Requires Coordinated Signaling through Thromboxane A2 and FcγIIA Receptor

2001 • 74 citations

A perfusion chamber developed to investigate thrombus formation and shear profiles in flowing native human blood at the apex of well-defined stenoses.

1994 • 70 citations

Cytoplasmic domains of GpIbα and GpIbβ regulate 14-3-3ζ binding to GpIb/IX/V

2000 • 69 citations

Role of cytoplasmic and releasable ADP in platelet aggregation induced by laminar shear stress.

1983 • 69 citations

Glycoprotein Ib-von Willebrand Factor Interactions Activate Tyrosine Kinases in Human Platelets

1997 • 68 citations

Platelet adhesion to laminin: role of Ca2+ and Mg2+ ions, shear rate, and platelet membrane glycoproteins

1992 • 66 citations

Thrombospondin-platelet interactions. Role of divalent cations, wall shear rate, and platelet membrane glycoproteins.

1993 • 65 citations

Flow cytometric studies of platelet responses to shear stress in whole blood

1995 • 65 citations

von Willebrand factor-mediated platelet adhesion to collagen involves platelet membrane glycoprotein IIb-IIIa as well as glycoprotein Ib.

1988 • 64 citations

Reduced Effect of Aspirin on Thrombus Formation at High Shear and Disturbed Laminar Blood Flow

1996 • 62 citations

Shear rate-dependent impairment of thrombus growth on collagen in nonanticoagulated blood from patients with von Willebrand disease and hemophilia A

1992 • 60 citations

Rap1B and Rap2B Translocation to the Cytoskeleton by von Willebrand Factor Involves FcγII Receptor-mediated Protein Tyrosine Phosphorylation

1999 • 57 citations

Human platelet signaling defect characterized by impaired production of inositol-1,4,5-triphosphate and phosphatidic acid and diminished Pleckstrin phosphorylation: evidence for defective phospholipase C activation

1996 • 56 citations

Platelet adhesion to laminin: role of Ca2+ and Mg2+ ions, shear rate, and platelet membrane glycoproteins

1992 • 55 citations

Reversible Ca2+-dependent Translocation of Protein Kinase C and Glucose-induced Insulin Release

1996 • 54 citations

Role of Platelet Membrane Glycoproteins and Von Willebrand Factor in Adhesion of Platelets to Subendothelium and Collagen

1987 • 51 citations

Cytosolic Calcium Changes in a Process of Platelet Adhesion and Cohesion on a von Willebrand Factor-Coated Surface Under Flow Conditions

1999 • 50 citations

Thrombin plays a key role in late platelet thrombus growth and/or stability. Effect of a specific thrombin inhibitor on thrombogenesis induced by aortic subendothelium exposed to flowing rabbit blood.

1994 • 48 citations

Modulation of thrombotic responses in moderately stenosed arteries by cigarette smoking and aspirin ingestion.

1994 • 47 citations

Glycoprotein IIb-IIIa-dependent aggregation by glycoprotein Ibα is reinforced by a Src family kinase inhibitor (PP1)-sensitive signalling pathway

2002 • 44 citations

Dose- and shear rate-dependent effects of heparin on thrombogenesis induced by rabbit aorta subendothelium exposed to flowing human blood.

1990 • 42 citations

Cytosolic Calcium Changes in a Process of Platelet Adhesion and Cohesion on a von Willebrand Factor-Coated Surface Under Flow Conditions

1999 • 41 citations

Fibronectin in platelet adhesion to human collagen types I and III. Use of nonfibrillar and fibrillar collagen in flowing blood studies.

1988 • 41 citations

Additions and Corrections to Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor.

1995 • 40 citations

Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3ζ

2000 • 40 citations

The effect of PGI2 and theophylline on the response of platelets subjected to shear stress

1981 • 39 citations

Thrombin plays a key role in late platelet thrombus growth and/or stability. Effect of a specific thrombin inhibitor on thrombogenesis induced by aortic subendothelium exposed to flowing rabbit blood.

1994 • 36 citations

Glycoprotein IIb-IIIa-dependent aggregation by glycoprotein Ibα is reinforced by a Src family kinase inhibitor (PP1)-sensitive signalling pathway

2002 • 33 citations

The effect of PGI2 and theophylline on the response of platelets subjected to shear stress

1981 • 29 citations

The Subendothelium of the HMEC-1 Cell Line Supports Thrombus Formation in the Absence of von Willebrand Factor and Collagen Types I, III and VI

2001 • 25 citations

ADP Receptor Antagonists and Converting Enzyme Systems Reduce Platelet Deposition onto Collagen

1992 • 18 citations

Role of von Willebrand Factor in Platelet Vessel‐Wall Interactions

1987 • 17 citations