Platelet adhesion to fibronectin in flow: dependence on surface concentration and shear rate, role of platelet membrane glycoproteins GP IIb/IIIa and VLA-5, and inhibition by heparin

Biometry: The Principles and Practice of Statistics in Biological Research

1969 • 21,227 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Biometry. The Principles and Practice of Statistics in Biological Research

1970 • 9,036 citations

Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule

1984 • 3,580 citations

Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.

1989 • 1,073 citations

The platelet membrane glycoprotein IIb-IIIa complex

1988 • 1,031 citations

Platelet Membrane Glycoprotein IIb/IIIa: Member of a Family of Arg-Gly-Asp—Specific Adhesion Receptors

1986 • 945 citations

An interaction between alpha-actinin and the beta 1 integrin subunit in vitro.

1990 • 851 citations

The function of multiple extracellular matrix receptors in mediating cell adhesion to extracellular matrix: preparation of monoclonal antibodies to the fibronectin receptor that specifically inhibit cell adhesion to fibronectin and react with platelet glycoproteins Ic-IIa.

1988 • 446 citations

Regulation of the fibronectin receptor affinity by divalent cations.

1988 • 441 citations

A perfusion chamber developed to investigate platelet interaction in flowing blood with human vessel wall cells, their extracellular matrix, and purified components.

1983 • 382 citations

Site-directed mutagenesis of the cell-binding domain of human fibronectin: Separable, synergistic sites mediate adhesive function

1988 • 372 citations

Characterization of the cell surface heterodimer VLA-4 and related peptides.

1987 • 340 citations

Platelet adhesion to collagen types I through VIII under conditions of stasis and flow is mediated by GPIa/IIa (alpha 2 beta 1-integrin)

1994 • 256 citations

Interaction of fibronectin with its receptor on platelets

1985 • 251 citations

The CS5 peptide is a second site in the IIICS region of fibronectin recognized by the integrin alpha 4 beta 1. Inhibition of alpha 4 beta 1 function by RGD peptide homologues

1991 • 244 citations

The role of platelet membrane glycoproteins Ib and IIb-IIIa in platelet adherence to human artery subendothelium

1986 • 237 citations

On the role of the platelet membrane skeleton in mediating signal transduction. Association of GP IIb-IIIa, pp60c-src, pp62c-yes, and the p21ras GTPase-activating protein with the membrane skeleton.

1993 • 235 citations

Role of factor VIII-von Willebrand factor and fibronectin in the interaction of platelets in flowing blood with monomeric and fibrillar human collagen types I and III.

1985 • 225 citations

Effects of Modifications of the RGD Sequence and Its Context on Recognition by the Fibronectin Receptor

1989 • 213 citations

Characterization of regions of fibronectin besides the arginine-glycine-aspartic acid sequence required for adhesive function of the cell-binding domain using site-directed mutagenesis

1991 • 180 citations

Prostacyclin (prostaglandin I2, PGI2) inhibits platelet adhesion and thrombus formation on subendothelium

1979 • 176 citations

Monoclonal antibodies against human platelet glycoprotein IIIa

1983 • 167 citations

Monoclonal antibody characterization of two distant sites required for function of the central cell-binding domain of fibronectin in cell adhesion, cell migration, and matrix assembly.

1991 • 156 citations

Glycoprotein Ic-IIa functions as an activation-independent fibronectin receptor on human platelets.

1988 • 137 citations

Glycoprotein Ib, von Willebrand factor, and glycoprotein IIb:IIIa are all involved in platelet adhesion to fibrin in flowing whole blood

1990 • 124 citations

Integrin alpha IIb beta 3 (platelet GPIIb-IIIa) recognizes multiple sites in fibronectin.

1991 • 105 citations

Cation-dependent changes in the binding specificity of the platelet receptor GPIIb/IIIa.

1990 • 101 citations

Interaction of heparin with fibronectin and isolated fibronectin domains

1990 • 95 citations

Fibronectin in artery subendothelium is important for platelet adhesion

1985 • 94 citations

Fibronectin-binding properties of the purified platelet glycoprotein IIb-IIIa complex.

1986 • 93 citations

Heparin binding to resting and activated platelets.

1989 • 77 citations

Heparin neutralization by platelet-rich thrombi. Role of platelet factor 4.

1994 • 74 citations

Recycling of platelet phosphorylation and cytoskeletal assembly.

1984 • 73 citations

Identification of glycoprotein Ib beta as one of the major proteins phosphorylated during exposure of intact platelets to agents that activate cyclic AMP-dependent protein kinase.

1987 • 68 citations

Fibronectin is required for platelet adhesion and for thrombus formation on subendothelium and collagen surfaces

1987 • 66 citations

Platelet adhesion to laminin: role of Ca2+ and Mg2+ ions, shear rate, and platelet membrane glycoproteins

1992 • 66 citations

Thrombospondin-platelet interactions. Role of divalent cations, wall shear rate, and platelet membrane glycoproteins.

1993 • 65 citations

Further Evidence that Glycoprotein IIb-IIIa Mediates Platelet Spreading on Subendothelium

1991 • 58 citations

Inhibition of platelet aggregation by a monoclonal antibody against human fibronectin.

1985 • 56 citations

Elution of fibronectin from collagen with chaotrophic agents

1980 • 39 citations

Adhesion of Blood Platelets to the Extracellular Matrix of Cultured Human Endothelial Cells

1987 • 38 citations

Platelets express a membrane protein complex immunologically related to the fibroblast fibronectin receptor and distinct from GPIIb/IIIa

1987 • 35 citations

The Platelet Membrane Glycoprotein IIb/IIIa Complex

1987 • 34 citations

Glycoprotein IIb-IIIa and RGD(S) are not important for fibronectin- dependent platelet adhesion under flow conditions

1988 • 31 citations

Platelet attachment and spreading on polystyrene surfaces: Dependence on fibronectin and plasma concentration

1985 • 29 citations

Structural characterization of heparin's binding domain for human platelets

1993 • 26 citations

Adhesion of platelets to purified solid-phase von Willebrand factor: effects of wall shear rate, ADP, thrombin, and ristocetin.

1989 • 24 citations

Platelet interactions with fibronectin: divalent cation-independent platelet adhesion to the gelatin-binding domain of fibronectin

1993 • 11 citations

Fibronectin is required for platelet adhesion and for thrombus formation on subendothelium and collagen surfaces

1987 • 8 citations

Platelet interactions with fibronectin: divalent cation-independent platelet adhesion to the gelatin-binding domain of fibronectin

1993 • 1 citations