Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin αIIbβ3

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 4,109 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 3,002 citations

PHOSPHOINOSITIDE KINASES

1998 • 1,321 citations

Initiation of Platelet Adhesion by Arrest onto Fibrinogen or Translocation on von Willebrand Factor

1996 • 1,178 citations

Signaling by Distinct Classes of Phosphoinositide 3-Kinases

1999 • 861 citations

Specific Synergy of Multiple Substrate–Receptor Interactions in Platelet Thrombus Formation under Flow

1998 • 809 citations

Activation of phospholipase Cgamma by PI 3-kinase-induced PH domain-mediated membrane targeting

1998 • 561 citations

Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase

1995 • 520 citations

Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen

2000 • 490 citations

Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate

1993 • 449 citations

Shear-induced platelet aggregation can be mediated by vWF released from platelets, as well as by exogenous large or unusually large vWF multimers, requires adenosine diphosphate, and is resistant to aspirin

1988 • 365 citations

A revised model of platelet aggregation

2000 • 349 citations

Identification of Flow-dependent Endothelial Nitric-oxide Synthase Phosphorylation Sites by Mass Spectrometry and Regulation of Phosphorylation and Nitric Oxide Production by the Phosphatidylinositol 3-Kinase Inhibitor LY294002

1999 • 331 citations

Activation of Phospholipase C-γ by Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 330 citations

Studies on apyrases

1961 • 256 citations

On the role of the platelet membrane skeleton in mediating signal transduction. Association of GP IIb-IIIa, pp60c-src, pp62c-yes, and the p21ras GTPase-activating protein with the membrane skeleton.

1993 • 235 citations

Phosphoinositide 3-Kinase Inhibition Spares Actin Assembly in Activating Platelets but Reverses Platelet Aggregation

1995 • 216 citations

A Key Role of Adenosine Diphosphate in the Irreversible Platelet Aggregation Induced by the PAR1-Activating Peptide Through the Late Activation of Phosphoinositide 3-Kinase

1999 • 214 citations

A Simplified Method for Culture of Endothelial Cells and Analysis of Adhesion of Blood Cells under Conditions of Flow

1993 • 202 citations

Interaction of asialo von Willebrand factor with glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and mediates platelet aggregation.

1985 • 150 citations

Physical Proximity and Functional Interplay of the Glycoprotein Ib-IX-V Complex and the Fc Receptor FcγRIIA on the Platelet Plasma Membrane

1998 • 149 citations

Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells.

1995 • 139 citations

Adhesion receptor activation of phosphatidylinositol 3-kinase. von Willebrand factor stimulates the cytoskeletal association and activation of phosphatidylinositol 3-kinase and pp60c-src in human platelets.

1994 • 133 citations

Analysis of the Roles of 14-3-3 in the Platelet Glycoprotein Ib-IX–Mediated Activation of Integrin αIIbβ3 Using a Reconstituted Mammalian Cell Expression Model

1999 • 132 citations

FcγRIIB1 Inhibition of BCR-Mediated Phosphoinositide Hydrolysis and Ca2+ Mobilization Is Integrated by CD19 Dephosphorylation

1997 • 121 citations

von Willebrand's disease antigen II. A new plasma and platelet antigen deficient in severe von Willebrand's disease.

1978 • 120 citations

Fibrinogen competes with von Willebrand factor for binding to the glycoprotein IIb/IIIa complex when platelets are stimulated with thrombin

1984 • 119 citations

A collagen-related peptide regulates phospholipase Cγ2 via phosphatidylinositol 3-kinase in human platelets

1999 • 118 citations

The von Willebrand Factor-Glycoprotein Ib/V/IX Interaction Induces Actin Polymerization and Cytoskeletal Reorganization in Rolling Platelets and Glycoprotein Ib/V/IX-transfected Cells

1999 • 118 citations

Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3ζ

2000 • 116 citations

Thrombin stimulates the production of a novel polyphosphoinositide in human platelets.

1990 • 107 citations

Synergistic Adhesive Interactions and Signaling Mechanisms Operating between Platelet Glycoprotein Ib/IX and Integrin αIIbβ3

2000 • 106 citations

Phosphoinositide 3-kinase activation and platelet function

1996 • 103 citations

Calpain Regulation of Cytoskeletal Signaling Complexes in Von Willebrand Factor-stimulated Platelets

1997 • 103 citations

Asialo von Willebrand factor interactions with platelets. Interdependence of glycoproteins Ib and IIb/IIIa for binding and aggregation.

1985 • 93 citations

Involvement of platelet glycoprotein IIb-IIIa (alpha IIb-beta 3 integrin) in thrombin-induced synthesis of phosphatidylinositol 3‘,4‘-bisphosphate.

1991 • 91 citations

Phosphatidylinositol 3,4,5-trisphosphate regulates Ca2+ entry via Btk in platelets and megakaryocytes without increasing phospholipase C activity

2000 • 91 citations

Signaling across the Platelet Adhesion Receptor Glycoprotein Ib-IX Induces αIIbβ3 Activation Both in Platelets and a Transfected Chinese Hamster Ovary Cell System

2000 • 85 citations

Induction of Nitric Oxide Synthase mRNA by Shear Stress Requires Intracellular Calcium and G-protein Signals and Is Modulated by PI 3 Kinase

1999 • 85 citations

Glycoprotein (GP) Ib-IX-transfected Cells Roll on a von Willebrand Factor Matrix under Flow

1999 • 82 citations

Platelet Activation by von Willebrand Factor Requires Coordinated Signaling through Thromboxane A2 and FcγIIA Receptor

2001 • 74 citations

Role of cytoplasmic and releasable ADP in platelet aggregation induced by laminar shear stress.

1983 • 69 citations

Isolation and purification of a hemorrhagic factor (wortmannin) from Fusarium oxysporum (N17B)

1988 • 66 citations

Lipid Products of Phosphoinositide 3-Kinase and Phosphatidylinositol 4′,5′-Bisphosphate Are Both Required for ADP-dependent Platelet Spreading

1998 • 59 citations

Novel Function of Phosphoinositide 3-Kinase in T Cell Ca2+ Signaling

2000 • 58 citations

Rap1B and Rap2B Translocation to the Cytoskeleton by von Willebrand Factor Involves FcγII Receptor-mediated Protein Tyrosine Phosphorylation

1999 • 57 citations

Protein Tyrosine Phosphorylation in Human Platelets during Shear Stress-Induced Platelet Aggregation (SIPA) Is Regulated by Glycoprotein (GP) Ib/IX as well as GP IIb/IIIa and Requires Intact Cytoskeleton and Endogenous ADP

1995 • 54 citations

Phosphatidylinositol 3,4,5-trisphosphate is formed from phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets

1994 • 51 citations

Von Willebrand factor and fibrinogen

1993 • 39 citations

Acute pathological effects on rats of orally administered wortmannin-containing preparations and purified wortmannin from Fusarium oxysporum

1989 • 33 citations

A role for phosphatidylinositol 3-kinase in platelet aggregation in response to low, but not high, concentrations of PAF or thrombin

1999 • 30 citations

Interaction between GPIbα and FcγIIA Receptor in Human Platelets

1999 • 25 citations