Platelet signal transduction defect with Gα subunit dysfunction and diminished Gα q in a patient with abnormal platelet responses

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

Diversity of group types, regulation, and function of phospholipase A2.

1994 • 1,444 citations

Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation.

1985 • 968 citations

G proteins

1992 • 871 citations

A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenic-like state in normal platelets and binds to glycoproteins IIb and/or IIIa.

1983 • 780 citations

Hemostasis and Thrombosis: Basic Principles and Clinical Practice

1994 • 723 citations

Platelets in Biology and Pathology

1981 • 644 citations

New roles for G-protein (βγ-dimers in transmembrane signalling

1993 • 633 citations

Catecholamine-stimulated GTPase activity in turkey erythrocyte membranes

1976 • 623 citations

Subunits βγ of heterotrimeric G protein activate β2 isoform of phospholipase C

1992 • 506 citations

Receptor-to-effector signaling through G proteins: Roles for βγ dimers as well as α subunits

1992 • 441 citations

G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets.

1994 • 441 citations

Gi2 mediates alpha 2-adrenergic inhibition of adenylyl cyclase in platelet membranes: in situ identification with G alpha C-terminal antibodies.

1989 • 374 citations

The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family

1991 • 373 citations

Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.

1991 • 367 citations

Rapid GDP release from Gsα in patients with gain and loss of endocrine function

1994 • 288 citations

Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor.

1990 • 285 citations

Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody.

1983 • 280 citations

The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase.

1992 • 248 citations

Regulation of the phosphoinositide hydrolysis pathway in thrombin-stimulated platelets by a pertussis toxin-sensitive guanine nucleotide-binding protein. Evaluation of its contribution to platelet activation and comparisons with the adenylate cyclase inhibitory protein, Gi.

1986 • 235 citations

An inherited bleeding disorder linked to a defective interaction between ADP and its receptor on platelets. Its influence on glycoprotein IIb-IIIa complex function.

1995 • 204 citations

Identification of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate

1992 • 189 citations

Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder.

1994 • 188 citations

Thrombin and Phorbol Esters Cause the Selective Phosphorylation of a G Protein Other Than Gi in Human Platelets

1989 • 181 citations

[1] Measurement of receptor-stimulated guanosine 5′-O-(γ-thio)triphosphate binding by G proteins

1994 • 136 citations

Activation of phospholipase C-beta 2 mutants by G protein alpha q and beta gamma subunits.

1993 • 134 citations

Expanding horizons for receptors coupled to G proteins: diversity and disease

1994 • 127 citations

Abnormalities in G protein-coupled signal transduction pathways in human disease.

1993 • 118 citations

Signaling through G Proteins and G Protein-coupled Receptors during Platelet Activation

1993 • 116 citations

Receptor and G protein-mediated responses to thrombin in HEL cells.

1991 • 109 citations

A G Protein Mutant That Inhibits Thrombin and Purinergic Receptor Activation of Phospholipase A₂

1990 • 108 citations

Decreased expression of phospholipase C-beta 2 isozyme in human platelets with impaired function

1996 • 95 citations

Solubilization and properties of Ca2+-dependent human platelet phospholipase A2

1986 • 94 citations

G protein coupling to the thrombin receptor in Chinese hamster lung fibroblasts.

1994 • 78 citations

Analysis of Gz alpha by site-directed mutagenesis. Sites and specificity of protein kinase C-dependent phosphorylation.

1993 • 77 citations

G-protein alpha o subunit: mutation of conserved cysteines identifies a subunitcontact surface and alters GDP affinity.

1993 • 73 citations

Mutations in G protein-linked receptors: Novel insights on disease

1993 • 73 citations

Abnormal inside-out signal transduction-dependent activation of glycoprotein IIb-IIIa in a patient with impaired pleckstrin phosphorylation

1996 • 70 citations

Turnover of arachidonic acid in the major diacyl and ether phospholipids of human platelets.

1985 • 68 citations

Reconstitution of thromboxane A2 receptor-stimulated phosphoinositide hydrolysis in isolated platelet membranes: involvement of phosphoinositide-specific phospholipase C-β and GTP-binding protein Gq

1993 • 64 citations

Purification and Reconstitution of the Ca2+-Pumping ATPase of Red Blood Cells

1994 • 64 citations

Differential sensitivity of arachidonic acid release and 1,2-diacylglycerol formation to pertussis toxin, GDP βS and NaF in saponin-permeabilized human platelets: possible evidence for distinct GTP-binding proteins involving phospholipase C and A2 activation

1987 • 58 citations

Human platelet signaling defect characterized by impaired production of inositol-1,4,5-triphosphate and phosphatidic acid and diminished Pleckstrin phosphorylation: evidence for defective phospholipase C activation

1996 • 56 citations

The thrombin receptor in human platelets is coupled to a GTP binding protein of the Gα_q family

1995 • 54 citations

Immunochemical Analysis of theα-Subunit of the Stimulatory G-Protein of Adenylyl Cyclase in Patients with Albright's Hereditary Osteodystrophy*

1990 • 53 citations

Defective signal transduction induced by thromboxane A2 in a patient with a mild bleeding disorder: impaired phospholipase C activation despite normal phospholipase A2 activation

1993 • 43 citations

Congenital Disorders of Platelet Function

1990 • 43 citations

Platelet secretion defect associated with impaired liberation of arachidonic acid and normal myosin light chain phosphorylation

1984 • 41 citations

Thromboxane-insensitive dog platelets have impaired activation of phospholipase C due to receptor-linked G protein dysfunction.

1993 • 39 citations

Impaired cytoplasmic ionized calcium mobilization in inherited platelet secretion defects

1989 • 38 citations

Gq Pathway Desensitizes Chemotactic Receptor-induced Calcium Signaling via Inositol Trisphosphate Receptor Down-regulation

1995 • 37 citations

Poly(A)-containing polyribosomal RNA in sea urchin embryos: Changes in proportion during development

1975 • 30 citations

β3 Integrin-Derived Peptide 217-230 Inhibits Fibrinogen Binding and Platelet Aggregation: Significance of RGD Sequences and Fibrinogen Aα-Chain

1993 • 21 citations

Concomitant defect in internal release and influx of calcium in patients with congenital platelet dysfunction and impaired agonist-induced calcium mobilization. Thromboxane production is not required for internal release of calcium.

1993 • 18 citations

Studies on platelet protein phosphorylation in patients with impaired responses to platelet agonists.

1990 • 17 citations

A haemorrhagic platelet disorder associated with altered stimulus‐response coupling and abnormal membrane phospholipid composition

1994 • 11 citations

Guanosine 5′-0-(3-thiotriphosphate) induced calcium release in human platelets is mediated by inositol 1,4,5-triphosphate

1992 • 3 citations

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