Pax genes and organogenesis

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

The development of Drosophila melanogaster

1994 • 3,057 citations

WT-1 is required for early kidney development

1993 • 1,976 citations

Induction of Ectopic Eyes by Targeted Expression of the eyeless Gene in Drosophila

1995 • 1,563 citations

Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

1990 • 1,300 citations

A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.

1995 • 1,118 citations

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

1996 • 1,106 citations

Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4

1994 • 1,056 citations

BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.

1995 • 1,021 citations

Pax-3, a novel murine DNA binding protein expressed during early neurogenesis.

1991 • 897 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

Pax-2 controls multiple steps of urogenital development

1995 • 865 citations

Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

1996 • 829 citations

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

1994 • 807 citations

The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas

1997 • 779 citations

Expression patterns of homeobox and other putative regulatory genes in the embryonic mouse forebrain suggest a neuromeric organization

1993 • 777 citations

Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene

1992 • 692 citations

splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3

1991 • 664 citations

The role ofPax-6in eye and nasal development

1995 • 660 citations

Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development

1997 • 606 citations

Patterning of mammalian somites by surface ectoderm and notochord: Evidence for sclerotome induction by a hedgehog homolog

1994 • 594 citations

The Drosophila smoothened Gene Encodes a Seven-Pass Membrane Protein, a Putative Receptor for the Hedgehog Signal

1996 • 591 citations

Pax2 contributes to inner ear patterning and optic nerve trajectory

1996 • 588 citations

The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo

1993 • 582 citations

Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma.

1994 • 580 citations

The midbrain-hindbrain phenotype of Wnt-1−Wnt-1− mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum

1992 • 579 citations

Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system

1990 • 562 citations

Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma

1993 • 546 citations

Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum

1994 • 509 citations

Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland

1990 • 479 citations

An exonic mutation in the HuP2 paired domain gene causes Waardenburg's syndrome

1992 • 470 citations

HoxGenes and Chordate Evolution

1996 • 448 citations

Influence of PAX6 Gene Dosage on Development: Overexpression Causes Severe Eye Abnormalities

1996 • 435 citations

Pax: A murine multigene family of paired box-containing genes

1991 • 427 citations

Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor.

1992 • 417 citations

Pax in development

1992 • 402 citations

The mouse Pax2 ^1Neu mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney

1996 • 381 citations

Forebrain patterning defects in Small eye mutant mice

1996 • 379 citations

Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.

1996 • 351 citations

The paired box encodes a second DNA-binding domain in the paired homeo domain protein.

1991 • 349 citations

The role of Pax-1 in axial skeleton development

1994 • 343 citations

Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway

1995 • 341 citations

Evolution and role of Pax genes

1993 • 337 citations

Crystal structure of a paired domain-DNA complex at 2.5 å resolution reveals structural basis for pax developmental mutations

1995 • 325 citations

undulated, a mutation affecting the development of the mouse skeleton, has a point mutation in the paired box of Pax 1

1988 • 323 citations

The PAX3-FKHR Fusion Protein Created by the t(2;13) Translocation in Alveolar Rhabdomyosarcomas Is A More Potent Transcriptional Activator than PAX3

1995 • 304 citations

Dysgenesis of cephalic neural crest derivatives in Pax7−/− mutant mice

1996 • 297 citations

Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities

1993 • 284 citations

Pax-2 is required for mesenchyme-to-epithelium conversion during kidney development

1993 • 273 citations

Repression of Pax-2 by WT1 during normal kidney development

1995 • 265 citations

Characterization and Developmental Expression of Pax9, a Paired-Box-Containing Gene Related to Pax1

1995 • 263 citations

Multiple modes of engrailed regulation in the progression towards cell fate determination

1991 • 248 citations

The oncogenic potential of Pax genes.

1993 • 247 citations

Loss of p53 function through PAX-mediated transcriptional repression.

1995 • 236 citations

Multiple functions for Pax6 in mouse eye and nasal development.

1996 • 231 citations

Pax1 is expressed during development of the thymus epithelium and is required for normal T-cell maturation

1996 • 228 citations

The Splotch mutation interferes with muscle development in the limbs

1993 • 205 citations

Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins

1996 • 194 citations

The pathology of development : a study of inherited skeletal disorders in animals

1963 • 192 citations

PAX genes

1994 • 190 citations

Deregulation of PAX-5 by translocation of the Emu enhancer of the IgH locus adjacent to two alternative PAX-5 promoters in a diffuse large-cell lymphoma.

1996 • 175 citations

From somites to vertebral column

2016 • 167 citations

Pax-2 is a DNA-binding protein in embryonic kidney and Wilms tumor

1992 • 162 citations

Isolation of two tissue-specific Drosophila paired box genes, Pox meso and Pox neuro.

1989 • 161 citations

Pax-2 expression in the murine neural plate precedes and encompasses the expression domains of Wnt-1 and En-1

1995 • 151 citations

Deregulated expression of PAX5 in medulloblastoma.

1995 • 141 citations

Zebrafish pax[b] is involved in the formation of the midbrain–hindbrain boundary

1992 • 127 citations

Two Pax-binding sites are required for early embryonic brain expression of an Engrailed-2 transgene

1996 • 125 citations

Conservation of Pax-6 in a lower chordate, the ascidian Phallusia mammillata

1997 • 125 citations

The paired-box transcription factor, PAX2, positively modulates expression of the Wilms' tumor suppressor gene (WT1).

1996 • 122 citations

undulated Phenotypes Suggest a Role of Pax-1 for the Development of Vertebral and Extravertebral Structures

1995 • 121 citations

Pax-5 is expressed at the midbrain-hindbrain boundary during mouse development

1992 • 113 citations

Expression of AvianPax1andPax9Is Intrinsically Regulated in the Pharyngeal Endoderm, but Depends on Environmental Influences in the Paraxial Mesoderm

1996 • 111 citations

Initiation of the proximodistal axis in insect legs

1995 • 107 citations

The fate of somitocoele cells in avian embryos

1994 • 104 citations

Transfilter induction of kidney tubules as a function of the extent and duration of intercellular contacts

1978 • 100 citations

Pax proteins and eye development

1996 • 86 citations

Early progression of thymocytes along the CD4/CD8 developmental pathway is regulated by a subset of thymic epithelial cells expressing transforming growth factor beta.

1994 • 82 citations

N-CAM alterations in splotch neural tube defect mouse embryos

1991 • 79 citations

PAX genes and human neural tube defects: an amino acid substitution in PAX1 in a patient with spina bifida.

1996 • 74 citations

Interaction between undulated and Patch leads to an extreme form of spina bifida in double-mutant mice

1995 • 74 citations

Transcription factors in disease

1996 • 73 citations

Role of the gooseberry gene in Drosophila embryos: maintenance of wingless expression by a wingless--gooseberry autoregulatory loop.

1993 • 63 citations

Functional dissection of the paired segmentation gene in Drosophila embryos.

1991 • 49 citations

Homeotic genes, the homeobox, and the spatial organization of the embryo.

1985 • 42 citations

Evolution of developmental decisions and morphogenesis: the view from two camps

1992 • 31 citations