Crystal structure of a paired domain-DNA complex at 2.5 å resolution reveals structural basis for pax developmental mutations

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

1992 • 3,863 citations

Accurate bond and angle parameters for X-ray protein structure refinement

1991 • 2,467 citations

Coupling of Local Folding to Site-Specific Binding of Proteins to DNA

1994 • 1,382 citations

Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5

1993 • 1,269 citations

Nuclear Magnetic Resonance

1956 • 1,215 citations

Mouse Small eye results from mutations in a paired-like homeobox-containing gene

1991 • 1,124 citations

Sequence-specific recognition of double helical nucleic acids by proteins.

1976 • 1,123 citations

Resolution of phase ambiguity in macromolecular crystallography

1985 • 1,040 citations

Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: A framework for understanding homeodomain-DNA interactions

1990 • 996 citations

The Definition of Generalized Helicoidal Parameters and of Axis Curvature for Irregular Nucleic Acids

1988 • 895 citations

Structure of E. coli Glutaminyl-tRNA Synthetase Complexed with tRNA ^Gln and ATP at 2.8 Å Resolution

1989 • 888 citations

Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma

1993 • 884 citations

Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region

1991 • 850 citations

Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene

1992 • 692 citations

Genomic structure, evolutionary conservation and aniridia mutations in the human PAX6 gene

1992 • 643 citations

Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma

1993 • 546 citations

Crystal structure of a MATα2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions

1991 • 538 citations

Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules

1994 • 506 citations

Structure of the Lambda Complex at 2.5 Å Resolution: Details of the Repressor-Operator Interactions

1988 • 500 citations

Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila

1986 • 497 citations

Mutations at the PAX6 locus are found in heterogeneous anterior segment malformations including Peters' anomaly

1994 • 489 citations

An exonic mutation in the HuP2 paired domain gene causes Waardenburg's syndrome

1992 • 470 citations

The structure of the Antennapedia homeodomain determined by NMR spectroscopy in solution: Comparison with prokaryotic repressors

1989 • 468 citations

Protein-DNA contacts in the structure of a homeodomain-DNA complex determined by nuclear magnetic resonance spectroscopy in solution.

1990 • 460 citations

Pax: A murine multigene family of paired box-containing genes

1991 • 427 citations

Pax in development

1992 • 402 citations

Model bias in macromolecular crystal structures

1992 • 397 citations

DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site.

1993 • 391 citations

Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma.

1993 • 373 citations

Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes.

1994 • 364 citations

Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing.

1994 • 361 citations

The paired box encodes a second DNA-binding domain in the paired homeo domain protein.

1991 • 349 citations

undulated, a mutation affecting the development of the mouse skeleton, has a point mutation in the paired box of Pax 1

1988 • 323 citations

The molecular basis of the undulated/Pax-1 mutation

1991 • 273 citations

Mutations in the paired domain of the human PAX3 gene cause Klein-Waardenburg syndrome (WS-III) as well as Waardenburg syndrome type I (WS-I).

1993 • 250 citations

The oncogenic potential of Pax genes.

1993 • 247 citations

The winged-helix DNA-binding motif: Another helix-turn-helix takeoff

1993 • 242 citations

Mutations in the PAX3 gene causing Waardenburg syndrome type 1 and type 2

1993 • 223 citations

Conformational and Helicoidal Analysis of 30 PS of Molecular Dynamics on the d(CGCGAATTCGCG) Double Helix: “Curves”, Dials and Windows

1989 • 216 citations

Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9

1993 • 212 citations

Hin Recombinase Bound to DNA: the Origin of Specificity in Major and Minor Groove Interactions

1994 • 206 citations

PAX genes

1994 • 190 citations

Generalized method of determining heavy-atom positions using the difference Patterson function

1987 • 139 citations

The Splotch-Delayed (Spd) Mouse Mutant Carries a Point Mutation within the Paired Box of the Pax-3 Gene

1993 • 112 citations

Nuclear Magnetic Resonance Solution Structure of the fushi tarazu Homeodomain from Drosophila and Comparison with the Antennapedia Homeodomain

1994 • 73 citations

A new Pax gene, Pax-9, maps to mouse Chromosome 12

1993 • 51 citations

Pax-3-DNA interaction: flexibility in the DNA binding and induction of DNA conformational changes by paired domains

1994 • 48 citations

Dissection of the Drosophila paired protein: Functional requirements for conserved motifs

1994 • 35 citations

Improving multiple isomorphous replacement phasing by heavy-atom refinement using solvent-flattened phases

1992 • 25 citations

Correction: Corrigendum: Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma

1994 • 5 citations