Loss of p53 function through PAX-mediated transcriptional repression.

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

The multistep nature of cancer

1993 • 1,872 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell death

1991 • 1,195 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma

1993 • 884 citations

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

1994 • 807 citations

Identification of a p53-dependent negative response element in the bcl-2 gene.

1994 • 747 citations

Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma.

1994 • 580 citations

Origin of Murine B Cell Lineages

1993 • 579 citations

Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma

1993 • 546 citations

Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis.

1992 • 536 citations

THE TUMOR SUPPRESSOR GENES

1993 • 509 citations

Cooperative interaction of an initiator-binding transcription initiation factor and the helix–loop–helix activator USF

1991 • 505 citations

Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor.

1992 • 417 citations

Pax in development

1992 • 402 citations

DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site.

1993 • 391 citations

p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumors.

1985 • 380 citations

Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma.

1993 • 373 citations

Molecular and cellular origins of B lymphocyte diversity

1991 • 346 citations

The tumore suppressor p53

1993 • 336 citations

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

1992 • 328 citations

p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression.

1992 • 297 citations

The molecular basis of the undulated/Pax-1 mutation

1991 • 273 citations

Expression of p53 during mouse embryogenesis

1991 • 249 citations

The oncogenic potential of Pax genes.

1993 • 247 citations

A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation.

1990 • 244 citations

THE GENETICS OF WILMS’ TUMOR—A Case of Disrupted Development

1994 • 232 citations

PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms’ tumors

1992 • 223 citations

Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9

1993 • 212 citations

p53: the ultimate tumor suppressor gene?

1992 • 209 citations

Pax: Gene regulators in the developing nervous system

1993 • 195 citations

Interactions between SV40 large‐tumor antigen and the growth suppressor proteins pRB and p53

1993 • 180 citations

Relationship of p53 to the control of apoptotic cell death.

1994 • 163 citations

Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53 - MDM2 complexes.

1993 • 152 citations

The 5′ region of the p53 gene: evolutionary conservation and evidence for a negative regulatory element.

1985 • 146 citations

MAMMALIAN PAX GENES

1994 • 143 citations

How loops, β sheets, and α helices help us to understand p53

1994 • 140 citations

Expression of the PAX2 gene in human fetal kidney and Wilms' tumor.

1992 • 131 citations

p53 Cellular Tumor Antigen: Analysis of mRNA Levels in Normal Adult Tissues, Embryos, and Tumors

1985 • 117 citations

The tumor suppressor p53 regulates its own transcription.

1993 • 115 citations

Characterization of the human p53 gene promoter.

1989 • 108 citations

Human p53 oncogene contains one promoter upstream of exon 1 and a second, stronger promoter within intron 1.

1988 • 88 citations

PAX5 expression correlates with increasing malignancy in human astrocytomas.

1995 • 79 citations

Regulation of gene expression at early stages of B-cell differentiation

1994 • 58 citations

The Tumor Suppressor p53 Regulates Its Own Transcription

1993 • 29 citations

11th Ernst Klenk Lecture. The p53 tumor suppressor gene and product.

1993 • 13 citations