Pax proteins and eye development

Induction of Ectopic Eyes by Targeted Expression of the eyeless Gene in Drosophila

1995 • 1,563 citations

Pax-6, a murine paired box gene, is expressed in the developing CNS

1991 • 1,226 citations

Mouse Small eye results from mutations in a paired-like homeobox-containing gene

1991 • 1,124 citations

A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos

1993 • 1,086 citations

Homology of the eyeless Gene of Drosophila to the Small eye Gene in Mice and Aniridia in Humans

1994 • 1,075 citations

Pax-2 controls multiple steps of urogenital development

1995 • 865 citations

Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region

1991 • 850 citations

PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects

1994 • 683 citations

The role ofPax-6in eye and nasal development

1995 • 660 citations

Genomic structure, evolutionary conservation and aniridia mutations in the human PAX6 gene

1992 • 643 citations

The human PAX6 gene is mutated in two patients with aniridia

1992 • 565 citations

Patterning activities of vertebrate hedgehog proteins in the developing eye and brain

1995 • 557 citations

Mutations at the PAX6 locus are found in heterogeneous anterior segment malformations including Peters' anomaly

1994 • 489 citations

Expression of the zebrafish paired box gene pax[zf-b] during early neurogenesis

1991 • 443 citations

Midline signalling is required for Pax gene regulation and patterning of the eyes

1995 • 433 citations

Spatially and temporally restricted expression of Pax2 during murine neurogenesis

1990 • 397 citations

Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing.

1994 • 361 citations

Expression of zebrafish nk2.2 is influenced by sonic hedgehog/vertebrate hedgehog-1 and demarcates a zone of neuronal differentiation in the embryonic forebrain

1995 • 337 citations

A mutation in the Pax-6 gene in rat small eye is associated with impaired migration of midbrain crest cells

1993 • 309 citations

Pax-6 Is First Expressed in a Region of Ectoderm Anterior to the Early Neural Plate: Implications for Stepwise Determination of the Lens

1994 • 292 citations

Order and coherence in the fate map of the zebrafish nervous system

1995 • 292 citations

Sequence and expression pattern ofpax-6are highly conserved between zebrafish and mice

1992 • 264 citations

Expression pattern of zebrafish pax genes suggests a role in early brain regionalization

1991 • 255 citations

New perspectives on eye evolution

1995 • 247 citations

Aniridia-associated cytogenetic rearrangements suggest that a position effect may cause the mutant phenotype

1995 • 215 citations

Regulatory gene expression boundaries demarcate sites of neuronal differentiation in the embryonic zebrafish forebrain

1994 • 213 citations

Zebrafish pax[zf-a]: a paired box-containing gene expressed in the neural tube.

1991 • 213 citations

Embryonic lens induction: shedding light on vertebrate tissue determination

1992 • 207 citations

Pax: Gene regulators in the developing nervous system

1993 • 195 citations

PAX genes

1994 • 190 citations

Small eye (Sey): a mouse model for the genetic analysis of craniofacial abnormalities

1988 • 182 citations

Uchida rat (rSey): a new mutant rat with craniofacial abnormalities resembling those of the mouse Sey mutant

1994 • 181 citations

Retinoic acid establishes ventral retinal characteristics

1996 • 178 citations

Comparative analysis of Pax-2 protein distributions during neurulation in mice and zebrafish

1992 • 169 citations

Patterning of the Caenorhabditis elegans head region by the Pax-6 family member vab-3

1995 • 167 citations

Kidney and Retinal Defects (Krd), a Transgene-Induced Mutation with a Deletion of Mouse Chromosome 19 That Includes the Pax2 Locus

1994 • 156 citations

Antibodies against pax6 immunostain amacrine and ganglion cells and neuronal progenitors, but not rod precursors, in the normal and regenerating retina of the goldfish

1996 • 156 citations

A complex array of positive and negative elements regulates the chicken alpha A-crystallin gene: involvement of Pax-6, USF, CREB and/or CREM, and AP-1 proteins.

1994 • 146 citations

Mutation of the PAX6 gene in patients with autosomal dominant keratitis.

1995 • 145 citations

Specification of sense-organ identity by a Caenorhabditis elegans Pax-6 homologue

1995 • 144 citations

MAMMALIAN PAX GENES

1994 • 143 citations

A Mouse Model of the Aniridia-Wilms Tumor Deletion Syndrome

1990 • 136 citations

Pax-6 is essential for lens-specific expression of zeta-crystallin.

1995 • 135 citations

Transcriptional Regulation of the Mouse αA-Crystallin Gene: Activation Dependent on a Cyclic AMP-Responsive Element (DE1/CRE) and a Pax-6-Binding Site

1995 • 127 citations

Expression of pax-6 during urodele eye development and lens regeneration.

1995 • 110 citations

Pax-6 and lens-specific transcription of the chicken delta 1-crystallin gene.

1995 • 104 citations

Midline signaling in the primordium of the zebrafish anterior central nervous system.

1994 • 98 citations

Characterization of a paired box- and homeobox-containing quail gene (Pax-QNR) expressed in the neuroretina.

1992 • 97 citations

Quail Pax-6 (Pax-QNR) encodes a transcription factor able to bind and trans-activate its own promoter.

1993 • 92 citations

Identification and Characterization of a Neuroretina-Specific Enhancer Element in the Quail Pax-6 (Pax-QNR) Gene

1995 • 62 citations

Molecular genetics of ocular disease

1995 • 52 citations

Early decisions in Drosophila eye morphogenesis

1995 • 48 citations

C-Myb acts as transcriptional activator of the quail PAX6 (PAX-QNR) promoter through two different mechanisms.

1995 • 26 citations

The role of Pax genes during murine development

1995 • 10 citations

PAX genes in human developmental anomalies

1994 • 7 citations