Resolving the identity myth: Key markers of functional CD4+FoxP3+ regulatory T cells

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

2017 • 4,003 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

CTLA-4 Control over Foxp3 ⁺ Regulatory T Cell Function

2008 • 2,656 citations

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

2006 • 2,516 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

FOXP3+ regulatory T cells in the human immune system

2010 • 2,283 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

2009 • 2,107 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

2009 • 1,688 citations

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

2006 • 1,496 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

2001 • 1,293 citations

Role of LAG-3 in Regulatory T Cells

2004 • 1,198 citations

Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression

2007 • 1,181 citations

Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans

2006 • 1,156 citations

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

2009 • 1,144 citations

Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells

2001 • 856 citations

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

2007 • 836 citations

Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

2004 • 805 citations

Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo

2001 • 658 citations

Identification of IL-17-producing FOXP3⁺regulatory T cells in humans

2009 • 657 citations

Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells

2004 • 618 citations

Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells

2001 • 615 citations

CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-10

2001 • 564 citations

From Vanilla to 28 Flavors: Multiple Varieties of T Regulatory Cells

2006 • 553 citations

CD4+CD25+ regulatory T cells in rheumatoid arthritis: Differences in the presence, phenotype, and function between peripheral blood and synovial fluid

2004 • 526 citations

Interaction of TNF with TNF Receptor Type 2 Promotes Expansion and Function of Mouse CD4+CD25+ T Regulatory Cells

2007 • 509 citations

Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and Periphery

2008 • 503 citations

CCR6 Regulates the Migration of Inflammatory and Regulatory T Cells

2008 • 492 citations

Homeostasis of Peripheral CD4+ T Cells: IL-2Rα and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers

2002 • 477 citations

Expression of the integrin α_Eβ₇identifies unique subsets of CD25⁺as well as CD25⁻regulatory T cells

2002 • 476 citations

IL-17–producing human peripheral regulatory T cells retain suppressive function

2009 • 471 citations

CD39+Foxp3+ Regulatory T Cells Suppress Pathogenic Th17 Cells and Are Impaired in Multiple Sclerosis

2009 • 454 citations

GARP (LRRC32) is essential for the surface expression of latent TGF-β on platelets and activated FOXP3 ⁺ regulatory T cells

2009 • 430 citations

Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice.

1999 • 428 citations

Blockade of CTLA-4 on CD4+CD25+ Regulatory T Cells Abrogates Their Function In Vivo

2006 • 422 citations

MHC Class II Expression Identifies Functionally Distinct Human Regulatory T Cells

2006 • 416 citations

OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset.

1990 • 399 citations

Phenotype, Localization, and Mechanism of Suppression of CD4+CD25+ Human Thymocytes

2002 • 384 citations

Mucosal T Lymphocyte Numbers Are Selectively Reduced in Integrin αE (CD103)-Deficient Mice

1999 • 377 citations

Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes

2008 • 354 citations

Compromised CD4⁺ CD25^high regulatory T‐cell function in patients with relapsing‐remitting multiple sclerosis is correlated with a reduced frequency of FOXP3‐positive cells and reduced FOXP3 expression at the single‐cell level

2007 • 339 citations

Loss of FOXP3 expression in natural human CD4⁺CD25⁺ regulatory T cells upon repetitive in vitro stimulation

2009 • 332 citations

Regulatory T-cell compartmentalization and trafficking

2006 • 323 citations

CD4+FoxP3+ regulatory T cells confer infectious tolerance in a TGF-β–dependent manner

2008 • 323 citations

LAG-3 Expression Defines a Subset of CD4+CD25highFoxp3+ Regulatory T Cells That Are Expanded at Tumor Sites

2010 • 315 citations

CCR6 expression defines regulatory effector/memory-like cells within the CD25+CD4+ T-cell subset

2004 • 314 citations

Negative Regulation of T Cell Homeostasis by Lymphocyte Activation Gene-3 (CD223)

2005 • 306 citations

Cutting Edge: Expression of TNFR2 Defines a Maximally Suppressive Subset of Mouse CD4+CD25+FoxP3+ T Regulatory Cells: Applicability to Tumor-Infiltrating T Regulatory Cells

2008 • 302 citations

A peripheral circulating compartment of natural naive CD4+ Tregs

2005 • 299 citations

Human memory FOXP3⁺Tregs secrete IL-17 ex vivo and constitutively express the T_H17 lineage-specific transcription factor RORγt

2009 • 293 citations

De novogeneration of antigen-specific CD4⁺CD25⁺regulatory T cells from human CD4⁺CD25^–cells

2005 • 284 citations

Persistence of naive CD45RA+ regulatory T cells in adult life

2005 • 267 citations

Inhibition of Human CD4+CD25+high Regulatory T Cell Function

2002 • 266 citations

Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells

2009 • 246 citations

ICOS Controls the Pool Size of Effector-Memory and Regulatory T Cells

2008 • 242 citations

Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen–specific CD8+ T-cell function in Hodgkin lymphoma patients

2006 • 238 citations

Membrane protein GARP is a receptor for latent TGF‐β on the surface of activated human Treg

2009 • 236 citations

FOXP3 Promoter Demethylation Reveals the Committed Treg Population in Humans

2008 • 227 citations

Generation of Potent and Stable Human CD4+ T Regulatory Cells by Activation-independent Expression of FOXP3

2007 • 218 citations

CD4+CD25+Foxp3+ T Cells and CD4+CD25−Foxp3+ T Cells in Aged Mice

2006 • 216 citations

CD4⁺CD25⁻LAG3⁺regulatory T cells controlled by the transcription factor Egr-2

2009 • 209 citations

Expression of CD39 by Human Peripheral Blood CD4+CD25+ T Cells Denotes a Regulatory Memory Phenotype

2010 • 206 citations

Toll-like receptors on regulatory T cells: expanding immune regulation

2006 • 201 citations

Co‐expression of TNFR2 and CD25 identifies more of the functional CD4⁺FOXP3⁺ regulatory T cells in human peripheral blood

2010 • 193 citations

Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures

2009 • 185 citations

Cutting Edge: Self-Peptides Drive the Peripheral Expansion of CD4+CD25+ Regulatory T Cells

2003 • 177 citations

Differentiation and Expansion of T Cells with Regulatory Function from Human Peripheral Lymphocytes by Stimulation in the Presence of TGF-β

2005 • 173 citations

Naive regulatory T cells: a novel subpopulation defined by resistance toward CD95L-mediated cell death

2006 • 170 citations

Regulation of Trafficking Receptor Expression in Human Forkhead Box P3+ Regulatory T Cells

2006 • 161 citations

Inducible costimulator (ICOS) is a marker for highly suppressive antigen-specific T cells sharing features of TH17/TH1 and regulatory T cells

2010 • 157 citations

Increased thioredoxin-1 production in human naturally occurring regulatory T cells confers enhanced tolerance to oxidative stress

2010 • 154 citations

Identification of a Regulatory T Cell Specific Cell Surface Molecule that Mediates Suppressive Signals and Induces Foxp3 Expression

2008 • 152 citations

Parasite-Dependent Expansion of TNF Receptor II–Positive Regulatory T Cells with Enhanced Suppressive Activity in Adults with Severe Malaria

2009 • 148 citations

CD49d provides access to “untouched” human Foxp3+ Treg free of contaminating effector cells

2008 • 144 citations

TNF Activates a NF-κB–Regulated Cellular Program in Human CD45RA– Regulatory T Cells that Modulates Their Suppressive Function

2010 • 143 citations

In vivo–activated CD103+CD4+ regulatory T cells ameliorate ongoing chronic graft-versus-host disease

2008 • 139 citations

Critical Role for TNF in the Induction of Human Antigen-Specific Regulatory T Cells by Tolerogenic Dendritic Cells

2010 • 127 citations

Expression of Costimulatory TNFR2 Induces Resistance of CD4+FoxP3− Conventional T Cells to Suppression by CD4+FoxP3+ Regulatory T Cells

2010 • 125 citations

GARP: a key receptor controlling FOXP3 in human regulatory T cells

2009 • 121 citations

Tumor eradication after cyclophosphamide depends on concurrent depletion of regulatory T cells: a role for cycling TNFR2-expressing effector-suppressor T cells in limiting effective chemotherapy

2008 • 118 citations

Increased CD127 expression on activated FOXP3⁺CD4⁺ regulatory T cells

2010 • 118 citations

Human memory FOXP3+ Treg secrete IL-17 ex-vivo and constitutively express the TH17 lineage specific transcription factor ROR{gamma}t

2009 • 117 citations

Co-signaling molecules of the B7-CD28 family in positive and negative regulation of T lymphocyte responses

2004 • 115 citations

Development of regulatory T cells requires IL-7Rα stimulation by IL-7 or TSLP

2008 • 115 citations

Skin‐versus gut‐skewed homing receptor expression and intrinsic CCR4 expression on human peripheral blood CD4⁺CD25⁺ suppressor T cells

2003 • 112 citations

Cutting Edge: TNFR-Shedding by CD4+CD25+ Regulatory T Cells Inhibits the Induction of Inflammatory Mediators

2008 • 110 citations

TNF-α: An Activator of CD4+FoxP3+TNFR2+ Regulatory T Cells

2010 • 106 citations

Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor α-chain are excluded from the analysis

2008 • 105 citations

Repertoire Requirements of CD4+ T Cells That Prevent Spontaneous Autoimmune Encephalomyelitis

2000 • 97 citations

TNF optimally activatives regulatory T cells by inducing TNF receptor superfamily members TNFR2, 4‐1BB and OX40

2011 • 93 citations

A unique subpopulation of CD4⁺ regulatory T cells controls wasting disease, IL‐10 secretion and T cell homeostasis

2003 • 89 citations

CCR6 Marks Regulatory T Cells as a Colon-Tropic, IL-10–Producing Phenotype

2010 • 84 citations

Activated T cells complicate the identification of regulatory T cells in rheumatoid arthritis

2008 • 76 citations

CIITA activates the expression of MHC class II genes in mouse T cells

1995 • 75 citations

Expression of CD103 identifies human regulatory T-cell subsets

2006 • 75 citations

Acquisition of regulatory function by human CD8⁺ T cells treated with anti‐CD3 antibody requires TNF

2010 • 72 citations

Anti-CTLA-4 treatment induces IL-10-producing ICOS+ regulatory T cells displaying IDO-dependent anti-inflammatory properties in a mouse model of colitis

2009 • 68 citations

Foxp3-Expressing CD103+ Regulatory T Cells Accumulate in Dendritic Cell Aggregates of the Colonic Mucosa in Murine Transfer Colitis

2006 • 51 citations

Flt3-L Increases CD4⁺CD25⁺Foxp3⁺ICOS⁺Cells in the Lungs of Cockroach-Sensitized and -Challenged Mice

2009 • 24 citations

Natural regulatory CD4 T cells expressing CD25

2001 • 14 citations

Function of Tumor Necrosis Factor Receptor Family Members on Regulatory T-Cells

2005 • 11 citations

Response: Is CD103 a good surface marker for in vivo–activated effector/memory Treg cells in patients with chronic inflammation? Unknown yet

2009 • 1 citations