CD49d provides access to “untouched” human Foxp3+ Treg free of contaminating effector cells

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

A Randomized, Placebo-Controlled Trial of Natalizumab for Relapsing Multiple Sclerosis

2006 • 3,172 citations

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

2006 • 2,516 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

1992 • 1,711 citations

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

2006 • 1,496 citations

Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood

2001 • 1,168 citations

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

2005 • 957 citations

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

2007 • 836 citations

Induction of FOXP3 expression in naive human CD4+FOXP3− T cells by T-cell receptor stimulation is transforming growth factor-β–dependent but does not confer a regulatory phenotype

2007 • 730 citations

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17–producing cells

2008 • 715 citations

Cutting Edge: IL-2 Is Critically Required for the In Vitro Activation of CD4+CD25+ T Cell Suppressor Function

2004 • 572 citations

Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans

2007 • 516 citations

Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion

2006 • 407 citations

Functional Regulatory T Cells Accumulate in Aged Hosts and Promote Chronic Infectious Disease Reactivation

2008 • 360 citations

Cutting Edge: Anti-CD25 Monoclonal Antibody Injection Results in the Functional Inactivation, Not Depletion, of CD4+CD25+ T Regulatory Cells

2006 • 333 citations

Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon β

2004 • 320 citations

CCR6 expression defines regulatory effector/memory-like cells within the CD25+CD4+ T-cell subset

2004 • 314 citations

Tregs and allergic disease

2004 • 287 citations

In vitro–expanded human CD4+CD25+ T-regulatory cells can markedly inhibit allogeneic dendritic cell–stimulated MLR cultures

2004 • 281 citations

Human regulatory T cells and their role in autoimmune disease

2006 • 264 citations

Expansion of Functional Endogenous Antigen-Specific CD4+CD25+ Regulatory T Cells from Nonobese Diabetic Mice

2005 • 254 citations

Tregs and allergic disease

2004 • 248 citations

Regulatory T‐cell physiology and application to treat autoimmunity

2006 • 236 citations

Immune reconstitution without graft-versus-host disease after haemopoietic stem-cell transplantation: a phase 1/2 study

2002 • 225 citations

Normal Human CD4+ Memory T Cells Display Broad Heterogeneity in Their Activation Threshold for Cytokine Synthesis

1998 • 202 citations

Tregs and transplantation tolerance

2004 • 195 citations

In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation

2005 • 182 citations

Regulatory T cells and organ transplantation

2004 • 177 citations

Human CD25⁺ regulatory T cells: two subsets defined by the integrins α₄β₇ or α₄β₁ confer distinct suppressive properties upon CD4⁺ T helper cells

2004 • 172 citations

Tregs and transplantation tolerance

2004 • 166 citations

Dipeptidyl‐peptidase IV/CD26 on T cells: analysis of an alternative T‐cell activation pathway

1998 • 133 citations

Isolation of CD4+CD25+ Regulatory T Cells for Clinical Trials

2006 • 133 citations

Anti-Tac (daclizumab, Zenapax) in the Treatment of Leukemia, Autoimmune Diseases, and in the Prevention of Allograft Rejection: A 25-Year Personal Odyssey

2007 • 131 citations

What does the future hold for cell-based tolerogenic therapy?

2007 • 129 citations

CD4⁺CD25⁺Regulatory T Cells and Their Therapeutic Potential

2005 • 126 citations

Engagement of specific T-cell surface molecules regulates cytoskeletal polarization in HTLV-1–infected lymphocytes

2005 • 114 citations

Human Regulatory T Cells Control Xenogeneic Graft-versus-Host Disease Induced by Autologous T Cells in RAG2−/−γc−/− Immunodeficient Mice

2006 • 92 citations

Partial Depletion of CD69^low‐expressing Natural Regulatory T Cells with the Anti‐CD25 Monoclonal Antibody PC61

2006 • 57 citations