Compromised CD4⁺ CD25^high regulatory T‐cell function in patients with relapsing‐remitting multiple sclerosis is correlated with a reduced frequency of FOXP3‐positive cells and reduced FOXP3 expression at the single‐cell level

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

1988 • 19,632 citations

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Revised Criteria for the Classification of Rheumatoid Arthritis

1990 • 7,730 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis

2001 • 6,888 citations

The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

2017 • 4,003 citations

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

IMMUNOLOGY OF MULTIPLE SCLEROSIS

2005 • 2,099 citations

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

2004 • 1,835 citations

FOXP3: Of Mice and Men

2005 • 929 citations

Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

2007 • 846 citations

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation

2007 • 804 citations

TNF downmodulates the function of human CD4+CD25hi T-regulatory cells

2006 • 768 citations

Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells

2004 • 618 citations

Deficient CD4+CD25high T Regulatory Cell Function in Patients with Active Systemic Lupus Erythematosus

2007 • 600 citations

Requirement for CD44 in Activated T Cell Extravasation into an Inflammatory Site

1997 • 560 citations

Natural Recovery and Protection from Autoimmune Encephalomyelitis: Contribution of CD4+CD25+ Regulatory Cells within the Central Nervous System

2005 • 545 citations

Anti–TNF-α therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-β

2007 • 475 citations

Isolation and functional characterization of regulatory CD25^brightCD4⁺ T cells from the target organ of patients with rheumatoid arthritis

2003 • 452 citations

Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis

2005 • 439 citations

The Subpopulation of CD4+CD25+ Splenocytes That Delays Adoptive Transfer of Diabetes Expresses L-Selectin and High Levels of CCR7

2002 • 383 citations

Decreased FOXP3 levels in multiple sclerosis patients

2005 • 367 citations

Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia

2005 • 364 citations

Interferon beta in the treatment of multiple sclerosis

1998 • 340 citations

α4-integrin-VCAM-1 binding mediates G protein–independent capture of encephalitogenic T cell blasts to CNS white matter microvessels

2001 • 330 citations

Secondary progressive multiple sclerosis: current knowledge and future challenges

2006 • 290 citations

Antibodies to CD44 and integrin α₄, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment

1999 • 287 citations

Induction of CD4⁺CD25⁺regulatory T cells by copolymer-I through activation of transcription factor Foxp3

2005 • 265 citations

Human regulatory T cells and their role in autoimmune disease

2006 • 264 citations

Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients

2007 • 193 citations

Secondary progressive in contrast to relapsing‐remitting multiple sclerosis patients show a normal CD4⁺CD25⁺ regulatory T‐cell function and FOXP3 expression

2006 • 189 citations

Entry of naive CD4 T cells into peripheral lymph nodes requires L-selectin.

1994 • 182 citations

Innate Immunity in Multiple Sclerosis: Myeloid Dendritic Cells in Secondary Progressive Multiple Sclerosis Are Activated and Drive a Proinflammatory Immune Response

2006 • 175 citations

Human CD25⁺ regulatory T cells: two subsets defined by the integrins α₄β₇ or α₄β₁ confer distinct suppressive properties upon CD4⁺ T helper cells

2004 • 172 citations

Induction of organ‐selective CD4⁺ regulatory T cell homing

2007 • 158 citations

Analyses of immunosenescent markers in patients with autoimmune disease

2007 • 154 citations

A functional polymorphism in the promoter/enhancer region of the FOXP3/Scurfin gene associated with type 1 diabetes

2003 • 152 citations

Thymic Export Function and T Cell Homeostasis in Patients with Relapsing Remitting Multiple Sclerosis

2003 • 144 citations

A CFSE based assay for measuring CD4+CD25+ regulatory T cell mediated suppression of auto-antigen specific and polyclonal T cell responses

2007 • 133 citations

Interferon beta-1a therapy enhances CD4+ regulatory T-cell function: An ex vivo and in vitro longitudinal study in relapsing−remitting multiple sclerosis

2006 • 129 citations

Impaired maturation and altered regulatory function of plasmacytoid dendritic cells in multiple sclerosis

2006 • 127 citations

Insights into the Immunopathogenesis of Multiple Sclerosis

2002 • 88 citations

Reduced Foxp3 Protein Expression Is Associated with Inflammatory Disease during Human T Lymphotropic Virus Type 1 Infection

2006 • 85 citations

Expression of CD103 identifies human regulatory T-cell subsets

2006 • 75 citations

Altered naive CD4 and CD8 T cell homeostasis in patients with relapsing-remitting multiple sclerosis: thymicversusperipheral (non-thymic) mechanisms

2005 • 52 citations

Altered phenotype and function of blood dendritic cells in multiple sclerosis are modulated by IFN-βand IL-10

2001 • 46 citations

Intrathecal production of Chlamydia pneumoniae-specific high-affinity antibodies is significantly associated to a subset of multiple sclerosis patients with progressive forms

2003 • 23 citations

Hyaluronate receptor (CD44) and integrin α4 (CD49d) are up-regulated on T cells during MS relapses

2005 • 17 citations