Generation of Potent and Stable Human CD4+ T Regulatory Cells by Activation-independent Expression of FOXP3

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

2006 • 2,516 citations

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

2006 • 1,496 citations

Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

2003 • 1,252 citations

Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans

2006 • 1,156 citations

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

2006 • 1,135 citations

Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7

2004 • 1,123 citations

Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function

2001 • 1,008 citations

Transient expression of FOXP3 in human activated nonregulatory CD4⁺ T cells

2006 • 973 citations

FOXP3: Of Mice and Men

2005 • 929 citations

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

2007 • 836 citations

Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

2004 • 805 citations

Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

2006 • 773 citations

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

2006 • 695 citations

Rapamycin Promotes Expansion of Functional CD4+CD25+FOXP3+ Regulatory T Cells of Both Healthy Subjects and Type 1 Diabetic Patients

2006 • 693 citations

Large-scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells

2004 • 505 citations

Generation Ex Vivo of TGF-β-Producing Regulatory T Cells from CD4+CD25− Precursors

2002 • 461 citations

Antigen-Specific Development of Primary and Memory T Cells in Vivo

1995 • 444 citations

Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells

2002 • 440 citations

The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs

2005 • 439 citations

MHC Class II Expression Identifies Functionally Distinct Human Regulatory T Cells

2006 • 416 citations

Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion

2006 • 407 citations

Molecular Mechanisms Underlying FOXP3 Induction in Human T Cells

2006 • 394 citations

Human CD4+ T Cells Express TLR5 and Its Ligand Flagellin Enhances the Suppressive Capacity and Expression of FOXP3 in CD4+CD25+ T Regulatory Cells

2005 • 368 citations

Transient regulatory T-cells: A state attained by all activated human T-cells

2006 • 336 citations

Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters

2004 • 318 citations

HIV Infection of Naturally Occurring and Genetically Reprogrammed Human Regulatory T-cells

2004 • 308 citations

IMGT/V-QUEST, an integrated software program for immunoglobulin and T cell receptor V-J and V-D-J rearrangement analysis

2004 • 307 citations

In vitro–expanded human CD4+CD25+ T-regulatory cells can markedly inhibit allogeneic dendritic cell–stimulated MLR cultures

2004 • 281 citations

Human regulatory T cells and their role in autoimmune disease

2006 • 264 citations

The T Cell Receptor FactsBook

2001 • 241 citations

Regulatory T-cell therapy: is it ready for the clinic?

2005 • 195 citations

In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation

2005 • 182 citations

Differentiation and Expansion of T Cells with Regulatory Function from Human Peripheral Lymphocytes by Stimulation in the Presence of TGF-β

2005 • 173 citations

Infectious tolerance and the long‐term acceptance of transplanted tissue

2006 • 168 citations

Retrovirus-Mediated Gene Transfer in Primary T Lymphocytes: Influence of the Transduction/Selection Process and ofex VivoExpansion on the T Cell Receptor β Chain Hypervariable Region Repertoire

2000 • 88 citations

High transdominant RevM10 protein levels are required to inhibit HIV-1 replication in cell lines and primary T cells: implication for gene therapy of AIDS

1997 • 78 citations

Costimulation of Transduced T Lymphocytes via T Cell Receptor-CD3 Complex and CD28 Leads to Increased Transcription of Integrated Retrovirus

1999 • 55 citations

UBD, a downstream element of FOXP3, allows the identification of LGALS3, a new marker of human regulatory T cells

2006 • 54 citations

Altered proximal T cell receptor (TCR) signaling in human CD4+CD25+ regulatory T cells

2006 • 41 citations

Highly efficient gene transfer in naive human T cells with a murine leukemia virus-based vector

2000 • 33 citations

Enhanced Transgene Expression in Quiescent and Activated Human CD8⁺T Cells

2004 • 32 citations

Transient T Cell Receptor β‐Chain Variable Region–Specific Expansions of CD4⁺and CD8⁺T Cells during the Early Phase of Pediatric Human Immunodeficiency Virus Infection: Characterization of Expanded Cell Populations by T Cell Receptor Phenotyping

2000 • 27 citations

Regulatory T cells: prospective for clinical application in hematopoietic stem cell transplantation

2005 • 22 citations

The clonal composition of human CD4+CD25+Foxp3+ cells determined by a comprehensive DNA-based multiplex PCR for TCRB gene rearrangements

2007 • 21 citations

Potential of Allospecific Gene-Engineered T Cells in Transplantation Gene Therapy: Specific T Cell Activation Determines Transgene Expressionin Vitroandin Vivo

2000 • 15 citations