TNF optimally activatives regulatory T cells by inducing TNF receptor superfamily members TNFR2, 4‐1BB and OX40

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

2009 • 1,688 citations

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

2009 • 1,079 citations

Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide

2003 • 976 citations

The role of TNF superfamily members in T-cell function and diseases

2009 • 846 citations

Interaction of TNF with TNF Receptor Type 2 Promotes Expansion and Function of Mouse CD4+CD25+ T Regulatory Cells

2007 • 509 citations

Tumor necrosis factors: developments during the last decade.

1996 • 473 citations

Phenotype, Localization, and Mechanism of Suppression of CD4+CD25+ Human Thymocytes

2002 • 384 citations

OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection

2008 • 383 citations

Cutting Edge: Expression of TNFR2 Defines a Maximally Suppressive Subset of Mouse CD4+CD25+FoxP3+ T Regulatory Cells: Applicability to Tumor-Infiltrating T Regulatory Cells

2008 • 302 citations

IL-2, -7, and -15, but Not Thymic Stromal Lymphopoeitin, Redundantly Govern CD4+Foxp3+ Regulatory T Cell Development

2008 • 250 citations

OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis

2009 • 220 citations

Co‐expression of TNFR2 and CD25 identifies more of the functional CD4⁺FOXP3⁺ regulatory T cells in human peripheral blood

2010 • 193 citations

Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs

2010 • 162 citations

Cutting Edge: OX40 Agonists Can Drive Regulatory T Cell Expansion if the Cytokine Milieu Is Right

2009 • 156 citations

Increased thioredoxin-1 production in human naturally occurring regulatory T cells confers enhanced tolerance to oxidative stress

2010 • 154 citations

OX40 is required for regulatory T cell–mediated control of colitis

2010 • 148 citations

Parasite-Dependent Expansion of TNF Receptor II–Positive Regulatory T Cells with Enhanced Suppressive Activity in Adults with Severe Malaria

2009 • 148 citations

TNF Receptor Type 2 (p75) Functions as a Costimulator for Antigen-Driven T Cell Responses In Vivo

2006 • 147 citations

TNF Activates a NF-κB–Regulated Cellular Program in Human CD45RA– Regulatory T Cells that Modulates Their Suppressive Function

2010 • 143 citations

Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells

2008 • 143 citations

Ex Vivo Expansion of CD4+CD25+FoxP3+ T Regulatory Cells Based on Synergy between IL-2 and 4-1BB Signaling

2007 • 139 citations

Critical Role for TNF in the Induction of Human Antigen-Specific Regulatory T Cells by Tolerogenic Dendritic Cells

2010 • 127 citations

Expression of Costimulatory TNFR2 Induces Resistance of CD4+FoxP3− Conventional T Cells to Suppression by CD4+FoxP3+ Regulatory T Cells

2010 • 125 citations

Tumor necrosis factor α blockade exacerbates murine psoriasis‐like disease by enhancing Th17 function and decreasing expansion of Treg cells

2010 • 121 citations

Tumor eradication after cyclophosphamide depends on concurrent depletion of regulatory T cells: a role for cycling TNFR2-expressing effector-suppressor T cells in limiting effective chemotherapy

2008 • 118 citations

Cutting Edge: TNFR-Shedding by CD4+CD25+ Regulatory T Cells Inhibits the Induction of Inflammatory Mediators

2008 • 110 citations

TNF-α: An Activator of CD4+FoxP3+TNFR2+ Regulatory T Cells

2010 • 106 citations

GM-CSF-induced, bone-marrow-derived dendritic cells can expand natural Tregs and induce adaptive Tregs by different mechanisms

2010 • 98 citations

Acquisition of regulatory function by human CD8⁺ T cells treated with anti‐CD3 antibody requires TNF

2010 • 72 citations

A non‐redundant role for OX40 in the competitive fitness of Treg in response to IL‐2

2010 • 62 citations

Role of the hypothalamus-pituitary-adrenal axis in the regulation of TNF production in mice. Effect of stress and inhibition of endogenous glucocorticoids.

1995 • 51 citations

Gene structure and chromosomal localization of the mouse homologue of rat OX40 protein

1995 • 27 citations