The multidrug resistance phenotype confers immunological resistance.

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

The multidrug transporter, a double-edged sword.

1988 • 763 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody.

1992 • 322 citations

A T. cruzi-secreted protein immunologically related to the complement component C9: Evidence for membrane pore-forming activity at low pH

1990 • 211 citations

Predominance of functional multidrug resistance (MDR-1) phenotype in CD34+ acute myeloid leukemia cells

1993 • 164 citations

Verapamil Restoration of Daunorubicin Responsiveness in Daunorubicin-resistant Ehrlich Ascites Carcinoma

1982 • 157 citations

Alteration of plasma membrane glycopeptides and gangliosides of Chinese hamster cells accompanying development of resistance to daunorubicin and vincristine.

1983 • 146 citations

Biological and immunological features of humanized M195 (anti-CD33) monoclonal antibodies.

1992 • 140 citations

Lower electrical membrane potential and altered pHi homeostasis in multidrug-resistant (MDR) cells: Further characterization of a series of MDR cell lines expressing different levels of P-glycoprotein

1993 • 131 citations

Isolation and characterization of adriamycin-resistant HL-60 cells which are not defective in the initial intracellular accumulation of drug.

1986 • 117 citations

Monoclonal antibody M195: a diagnostic marker for acute myelogenous leukemia.

1989 • 102 citations

Inhibition of Multidrug‐resistant Human Tumor Growth in Athymic Mice by Anti‐P‐glycoprotein Monoclonal Antibodies

1989 • 94 citations

Monoclonal antibodies against P-glycoprotein, an MDR1 gene product, inhibit interleukin-2 release from PHA-activated lymphocytes.

1996 • 93 citations

The role of the MDR protein in altered drug translocation across tumor cell membranes

1995 • 79 citations

Multidrug resistance after retroviral transfer of the human MDR1 gene correlates with P-glycoprotein density in the plasma membrane and is not affected by cytotoxic selection.

1991 • 78 citations

Characterization of monoclonal antibodies recognizing a Mr 180,000 P-glycoprotein: differential expression of the Mr 180,000 and Mr 170,000 P-glycoproteins in multidrug-resistant human tumor cells.

1989 • 68 citations

Transfection of mu MDR 1 Inhibits Na+-Independent Cl-/-HCO3 Exchange in Chinese Hamster Ovary Cells

1994 • 40 citations

Single channel currents induced by complement in antibody-coated cell membranes.

1981 • 35 citations

Inaugural editorial

1995 • 1 citations