Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis

SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling

1997 • 10,943 citations

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases

2003 • 4,348 citations

How Matrix Metalloproteinases Regulate Cell Behavior

2001 • 3,860 citations

Matrix Metalloproteinases and Other Matrix Proteinases in Relation to Cariology: The Era of ‘Dentin Degradomics'

2015 • 2,211 citations

Protein degradation and protection against misfolded or damaged proteins

2003 • 2,022 citations

The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis

1999 • 1,872 citations

Autoimmunity to type II collagen an experimental model of arthritis.

1977 • 1,599 citations

Matrix metalloproteinases: a tail of a frog that became a prince

2002 • 1,082 citations

Membrane Type 1 Matrix Metalloproteinase Digests Interstitial Collagens and Other Extracellular Matrix Macromolecules

1997 • 926 citations

Matrix Metalloproteinase-2 Is an Interstitial Collagenase

1995 • 917 citations

On the attribution and additivity of binding energies

1981 • 902 citations

Molecular Structure of Collagen

1963 • 715 citations

Structure of Collagen

1955 • 701 citations

The Collagenolytic Activity of Cathepsin K Is Unique among Mammalian Proteinases

1998 • 631 citations

The Activity of Collagenase-1 Is Required for Keratinocyte Migration on a Type I Collagen Matrix

1997 • 600 citations

Take five—BACE and the γ-secretase quartet conduct Alzheimer's amyloid β-peptide generation

2004 • 546 citations

Type I collagen is thermally unstable at body temperature

2002 • 519 citations

Molecular Determinants of Metalloproteinase Substrate Specificity: Matrix Metalloproteinase Substrate Binding Domains, Modules, and Exosites

2002 • 493 citations

Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate

1990 • 381 citations

Matrix metalloproteinases and TIMPs

2000 • 379 citations

The collagen substrate specificity of human skin fibroblast collagenase.

1981 • 371 citations

The Role of the C-terminal Domain of Human Collagenase-3 (MMP-13) in the Activation of Procollagenase-3, Substrate Specificity, and Tissue Inhibitor of Metalloproteinase Interaction

1997 • 345 citations

Specific degradation of the collagen molecule by tadpole collagenolytic enzyme.

1965 • 339 citations

Chain conformation in the collagen molecule

1979 • 315 citations

Human matrix metalloproteinase specificity studies using collagen sequence-based synthetic peptides

1996 • 313 citations

The role of the C-terminal domain in collagenase and stromelysin specificity.

1992 • 311 citations

Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids

1992 • 267 citations

Metalloproteinase inhibitors and the prevention of connective tissue breakdown

1996 • 260 citations

Structure of full-length porcine synovial collagenase reveals a C-terminal domain containing a calcium-linked, four-bladed β-propeller

1995 • 260 citations

The Matrix Metalloproteinase Family

1998 • 225 citations

Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice

1999 • 213 citations

Fragments of human fibroblast collagenase. Purification and characterization

1989 • 210 citations

Specific collagenolysis by gelatinase A, MMP‐2, is determined by the hemopexin domain and not the fibronectin‐like domain

2001 • 209 citations

Purification and characterization of a bone metalloproteinase that degrades gelatin and types IV and V collagen

1985 • 195 citations

A model for interstitial collagen catabolism by mammalian collagenases

1991 • 182 citations

The crystal and molecular structure of a collagen-like peptide with A biologically relevant sequence

2001 • 181 citations

A program of cell death and extracellular matrix degradation is activated in the amnion before the onset of labor.

1996 • 169 citations

The Helping Hand of Collagenase-3 (MMP-13): 2.7 Å Crystal Structure of its C-terminal Haemopexin-like Domain

1996 • 137 citations

Identification of the 183RWTNNFREY191Region as a Critical Segment of Matrix Metalloproteinase 1 for the Expression of Collagenolytic Activity

2000 • 125 citations

Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene.

1990 • 121 citations

Fragmentation of human polymorphonuclear-leucocyte collagenase

1993 • 118 citations

The presence of organic phosphorus in collagens and gelatins

1964 • 115 citations

Purification of human collagenases with a hydroxamic acid affinity column

1986 • 114 citations

Recognition and catabolism of synthetic heterotrimeric collagen peptides by matrix metalloproteinases

2000 • 109 citations

A helping hand for collagenases: the haemopexin-like domain

1995 • 103 citations

Gelatin: A Poor Substrate for a Mammalian Collagenase

1973 • 65 citations

Proteolytic Response to Oxidative Stress in Mammalian Cells

2002 • 63 citations

Control of lipid metabolism by regulated intramembrane proteolysis of sterol regulatory element binding proteins (SREBPs)

2003 • 59 citations

Collagen/collagenase interaction: Does the enzyme mimic the conformation of its own substrate?

1996 • 58 citations

Structural Properties of a Collagenous Heterotrimer that Mimics the Collagenase Cleavage Site of Collagen Type I

2002 • 52 citations

The gelatinolytic activity of rat uterus collagenase.

1985 • 39 citations

Heterotrimeric Collagen Peptides as Fluorogenic Collagenase Substrates: Synthesis, Conformational Properties, and Enzymatic Digestion

2000 • 35 citations

<b>MECHANISM OF COLLAGEN DEGRADATION BY COLLAGENASE: A TRANSITION PROCESS OF THE COLLAGEN MOLECULE FROM COLLAGENASE-SUBSTRATE TO </b><b>GELATINASE-SUBSTRATE </b>

1983 • 21 citations

Do mammalian collagenases and DNA restriction endonucleases share a similar mechanism for cleavage site recognition?

1977 • 12 citations

Human matrix metalloproteinase specificity studies using collagen sequence‐based synthetic peptides

1996 • 10 citations