A helping hand for collagenases: the haemopexin-like domain

Matrix metalloproteinases and their inhibitors in connective tissue remodeling

1991 • 3,309 citations

Matrix Metalloproteinases: A Review

1993 • 2,998 citations

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

The matrix‐degrading metalloproteinases

1992 • 1,383 citations

COLLAGENOLYTIC ACTIVITY IN AMPHIBIAN TISSUES: A TISSUE CULTURE ASSAY

1962 • 1,275 citations

Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc‐binding environments (HEXXHXXGXXH and Met‐turn) and topologies and should be grouped into a common family, the ‘metzincins’

1993 • 729 citations

Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.

1990 • 699 citations

The metzincins — Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a super family of zinc‐peptidases

1995 • 691 citations

Structural basis of the action of thermolysin and related zinc peptidases

1988 • 675 citations

The Matrix Metalloproteinases and Their Inhibitors

1992 • 604 citations

Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2.

1989 • 594 citations

Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate

1990 • 381 citations

Structural biochemistry and activation of matrix metalloproteases

1993 • 347 citations

The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity.

1994 • 342 citations

Specific degradation of the collagen molecule by tadpole collagenolytic enzyme.

1965 • 339 citations

Structure of the Catalytic Domain of Fibroblast Collagenase Complexed with an Inhibitor

1994 • 321 citations

Structure of astacin and implications for activation of astacins and zinc-ligation of collagenases

1992 • 319 citations

The role of the C-terminal domain in collagenase and stromelysin specificity.

1992 • 311 citations

The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases

1992 • 268 citations

Structure of full-length porcine synovial collagenase reveals a C-terminal domain containing a calcium-linked, four-bladed β-propeller

1995 • 260 citations

The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: A kinetic analysis of the inhibition of gelatinase A

1993 • 237 citations

First structure of a snake venom metalloproteinase: a prototype for matrix metalloproteinases/collagenases.

1993 • 215 citations

Assessment of the role of the fibronectin-like domain of gelatinase A by analysis of a deletion mutant.

1994 • 211 citations

Domain structure of human 72-kDa gelatinase/type IV collagenase. Characterization of proteolytic activity and identification of the tissue inhibitor of metalloproteinase-2 (TIMP-2) binding regions.

1992 • 201 citations

Structure of the catalytic domain of human fibroblast collagenase complexed with an inhibitor

1994 • 197 citations

X-ray Structures of Human Neutrophil Collagenase Complexed with Peptide Hydroxamate and Peptide Thiol Inhibitors. Implications for Substrate Binding and Rational Drug Design

1995 • 170 citations

Structure of human neutrophil collagenase reveals large S1′ specificity pocket

1994 • 163 citations

The NMR structure of the inhibited catalytic domain of human stromelysin–1

1994 • 154 citations

Tumor cell surface-associated binding site for the M(r) 72,000 type IV collagenase.

1992 • 153 citations

Sequence specificities of human fibroblast and neutrophil collagenases.

1991 • 146 citations

Alanine scanning mutagenesis and functional analysis of the fibronectin-like collagen-binding domain from human 92-kDa type IV collagenase.

1992 • 146 citations

Structural implications for the role of the N terminus in the ‘superactivation’ of collagenases

1994 • 135 citations

Structure-function relationship of human neutrophil collagenase: identification of regions responsible for substrate specificity and general proteinase activity.

1993 • 128 citations

Fragmentation of human polymorphonuclear-leucocyte collagenase

1993 • 118 citations

Role of zinc-binding- and hemopexin domain-encoded sequences in the substrate specificity of collagenase and stromelysin-2 as revealed by chimeric proteins.

1993 • 109 citations

Characterization and activation of procollagenase from human polymorphonuclear leucocytes

1990 • 101 citations

1.8 å crystal structure of the C-terminal domain of rabbit serum haemopexin

1995 • 96 citations

Binding of latent and high M r active forms of stromelysin to collagen is mediated by the C-terminal domain

1991 • 95 citations

Nucleotide sequence and organization of the human S-protein gene: repeating peptide motifs in the "pexin" family and a model for their evolution

1987 • 92 citations

The gelatin-binding site of human 72 kDa type IV collagenase (gelatinase A)

1994 • 88 citations

An internal cysteine plays a role in the maintenance of the latency of human fibroblast collagenase

1991 • 84 citations

Different Domain Interactions Are Involved in the Binding of Tissue Inhibitors of Metalloproteinases to Stromelysin-1 and Gelatinase A

1994 • 77 citations

The primary structure of human hemopexin deduced from cDNA sequence: evidence for internal, repeating homology

1985 • 75 citations

Metalloproteinase super–families and drug design

1994 • 62 citations

New folds for all-β proteins

1993 • 62 citations

A domain structure common to hemopexin, vitronectin, interstitial collagenase, and a collagenase homolog.

1987 • 41 citations

Fragments of human fibroblast collagenase: interaction with metalloproteinase inhibitors and substrates

1994 • 31 citations

Homology of placental protein 11 and pea seed albumin 2 with vitronectin

1991 • 30 citations

The second zinc atom in the matrix metalloproteinase catalytic domain is absent in the full‐length enzymes: a possible role for the C‐terminal domain

1995 • 28 citations