Recognition and catabolism of synthetic heterotrimeric collagen peptides by matrix metalloproteinases

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Matrix Metalloproteinases

1999 • 3,774 citations

X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

1992 • 3,488 citations

Matrix Metalloproteinases: A Review

1993 • 2,998 citations

Structure of 20S proteasome from yeast at 2.4Å resolution

1997 • 2,211 citations

Membrane Type 1 Matrix Metalloproteinase Digests Interstitial Collagens and Other Extracellular Matrix Macromolecules

1997 • 926 citations

Matrix Metalloproteinase-2 Is an Interstitial Collagenase

1995 • 917 citations

Real-time biospecific interaction analysis using surface plasmon resonance and a sensor chip technology.

1991 • 909 citations

Biochemical Characterization of Human Collagenase-3

1996 • 871 citations

Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas

1994 • 769 citations

A novel hydrogel matrix on gold surfaces in surface plasmon resonance sensors for fast and efficient covalent immobilization of ligands

1990 • 759 citations

Molecular Structure of Collagen

1963 • 715 citations

Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein.

1986 • 645 citations

Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1

1997 • 610 citations

Matrix metal loproteinases and the development of cancer

1996 • 569 citations

The Family of Matrix Metalloproteinases^a

1994 • 437 citations

Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin)

1990 • 431 citations

Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases.

1990 • 406 citations

The collagen substrate specificity of human skin fibroblast collagenase.

1981 • 371 citations

Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor

1998 • 360 citations

The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity.

1994 • 342 citations

Structure of the Catalytic Domain of Fibroblast Collagenase Complexed with an Inhibitor

1994 • 321 citations

Chain conformation in the collagen molecule

1979 • 315 citations

Human matrix metalloproteinase specificity studies using collagen sequence-based synthetic peptides

1996 • 313 citations

The role of the C-terminal domain in collagenase and stromelysin specificity.

1992 • 311 citations

Sequence dependent conformational variations of collagen triple-helical structure.

1999 • 303 citations

Human β-tryptase is a ring-like tetramer with active sites facing a central pore

1998 • 301 citations

Relating matrix metalloproteinase structure to function: Why the “hemopexin” domain?

1997 • 300 citations

Supercoiled Protein Motifs: The Collagen Triple-Helix and the α-Helical Coiled Coil

1998 • 292 citations

Stromelysin‐1: Three‐dimensional structure of the inhibited catalytic domain and of the C‐truncated proenzyme

1995 • 289 citations

The collagen substrate specificity of human neutrophil collagenase.

1987 • 285 citations

A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling.

1995 • 280 citations

Kinetic and Concentration Analysis Using BIA Technology

1994 • 272 citations

Binding of gelatinases A and B to type-I collagen and other matrix components

1995 • 270 citations

The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases

1992 • 268 citations

Matrix metalloproteinases

1998 • 267 citations

Structure of full-length porcine synovial collagenase reveals a C-terminal domain containing a calcium-linked, four-bladed β-propeller

1995 • 260 citations

Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors.

1999 • 238 citations

Extracellular Matrix Binding Properties of Recombinant Fibronectin Type II-like Modules of Human 72-kDa Gelatinase/Type IV Collagenase

1995 • 221 citations

Assessment of the role of the fibronectin-like domain of gelatinase A by analysis of a deletion mutant.

1994 • 211 citations

Fragments of human fibroblast collagenase. Purification and characterization

1989 • 210 citations

Structure of the catalytic domain of human fibroblast collagenase complexed with an inhibitor

1994 • 197 citations

Acetyl-Terminated and Template-Assembled Collagen-Based Polypeptides Composed of Gly-Pro-Hyp Sequences. 2. Synthesis and Conformational Analysis by Circular Dichroism, Ultraviolet Absorbance, and Optical Rotation

1996 • 195 citations

1.56 Å structure of mature truncated human fibroblast collagenase

1994 • 183 citations

A model for interstitial collagen catabolism by mammalian collagenases

1991 • 182 citations

[28] Gelatinases A and B

1995 • 182 citations

X-ray Structures of Human Neutrophil Collagenase Complexed with Peptide Hydroxamate and Peptide Thiol Inhibitors. Implications for Substrate Binding and Rational Drug Design

1995 • 170 citations

Structure of human neutrophil collagenase reveals large S1′ specificity pocket

1994 • 163 citations

The role of polar and hydrophobic interactions for the molecular packing of type I collagen: A three-dimensional evaluation of the amino acid sequence

1978 • 163 citations

Direct activation of human neutrophil procollagenase by recombinant stromelysin

1993 • 162 citations

Matrix metalloproteinases and TIMPs: properties and implications for the rheumatic diseases

1998 • 158 citations

Alanine scanning mutagenesis and functional analysis of the fibronectin-like collagen-binding domain from human 92-kDa type IV collagenase.

1992 • 146 citations

The Helping Hand of Collagenase-3 (MMP-13): 2.7 Å Crystal Structure of its C-terminal Haemopexin-like Domain

1996 • 137 citations

[26] Human neutrophil collagenase

1995 • 129 citations

Structure-function relationship of human neutrophil collagenase: identification of regions responsible for substrate specificity and general proteinase activity.

1993 • 128 citations

Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene.

1990 • 121 citations

Fragmentation of human polymorphonuclear-leucocyte collagenase

1993 • 118 citations

X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily

1996 • 112 citations

Role of zinc-binding- and hemopexin domain-encoded sequences in the substrate specificity of collagenase and stromelysin-2 as revealed by chimeric proteins.

1993 • 109 citations

The gelatinolytic activity of human skin fibroblast collagenase.

1982 • 105 citations

A helping hand for collagenases: the haemopexin-like domain

1995 • 103 citations

Steps involved in activation of the complex of pro-matrix metalloproteinase 2 (progelatinase A) and tissue inhibitor of metalloproteinases (TIMP)-2 by 4-aminophenylmercuric acetate

1995 • 103 citations

Matrix metalloproteases: variations on a theme

1998 • 100 citations

Design and synthesis of heterotrimeric collagen peptides with a built‐in cystine‐knot Models for collagen catabolism by matrix‐metalloproteases

1996 • 95 citations

Disulfide-Bridged Heterotrimeric Collagen Peptides Containing the Collagenase Cleavage Site of Collagen Type I. Synthesis and Conformational Properties

1999 • 94 citations

The C‐terminal (haemopexin‐like) domain structure of human gelatinase A (MMP2): structural implications for its function

1996 • 94 citations

The Involvement of the Fibronectin Type II-like Modules of Human Gelatinase A in Cell Surface Localization and Activation

1998 • 89 citations

The gelatin-binding site of human 72 kDa type IV collagenase (gelatinase A)

1994 • 88 citations

Activation of Human Neutrophil Procollagenase by Stromelysin 2

1996 • 70 citations

Mutation of the Active Site Glutamic Acid of Human Gelatinase A: Effects on Latency, Catalysis, and the Binding of Tissue Inhibitor of Metalloproteinases-1

1994 • 67 citations

Collagen-based structures containing the peptoid residue N-isobutylglycine (Nleu): Synthesis and biophysical studies of Gly-Pro-Nleu sequences by circular dichroism, ultraviolet absorbance, and optical rotation

1998 • 67 citations

The Recombinant Catalytic Domain of Human Neutrophil Collagenase Lacks Type I Collagen Substrate Specificity

1993 • 60 citations

Analysis of the contribution of the hinge region of human neutrophil collagenase (HNC, MMP‐8) to stability and collagenolytic activity by alanine scanning mutagenesis

1997 • 59 citations

Collagen/collagenase interaction: Does the enzyme mimic the conformation of its own substrate?

1996 • 58 citations

X-ray Structures of Human Neutrophil Collagenase Complexed with Peptide Hydroxamate and Peptide Thiol Inhibitors. Implications for Substrate Binding and Rational Drug Design

1995 • 50 citations

Expression of Human Pro-Matrix Metalloproteinase 3 that Lacks the N-terminal 34 Residues in Escherichia coli: Autoactivation and Interaction with Tissue Inhibitor of Metalloproteinase 1 (TIMP-1)

1998 • 50 citations

Isolation and characterization of A peptide containing the site of cleavage of the chick skin collagen α1[I] chain by animal collagenases

1979 • 39 citations

The Collagen Triple-Helix: Correlation of Conformation with Biological Activities

1995 • 38 citations

The gelatin‐binding site of the second type‐II domain of gelatinase A/MMP‐2

1999 • 37 citations

Heterotrimeric collagen peptides containing functional epitopes. Synthesis of single-stranded collagen type I peptides related to the collagenase cleavage site

1999 • 30 citations

A new strategy for regioselective interstrand disulfide bridging of multiple cysteine peptides

1999 • 23 citations

Patterns of Hydration In Crystalline Collagen Peptides

1998 • 18 citations

Collagen‐based structures containing the peptoid residue N‐isobutylglycine (Nleu): Synthesis and biophysical studies of Gly‐Pro‐Nleu sequences by circular dichroism, ultraviolet absorbance, and optical rotation

1996 • 18 citations

Evidence for a Triple Helix Recognition Site in the Hemopexin‐like Domains of Human Fibroblast and Neutrophil Interstitial Collagenases^a

1994 • 18 citations