The Collagenolytic Activity of Cathepsin K Is Unique among Mammalian Proteinases

Matrix Metalloproteinases: A Review

1993 • 2,998 citations

Pycnodysostosis, a Lysosomal Disease Caused by Cathepsin K Deficiency

1996 • 1,003 citations

Connective Tissue and Its Heritable Disorders

2002 • 930 citations

Membrane Type 1 Matrix Metalloproteinase Digests Interstitial Collagens and Other Extracellular Matrix Macromolecules

1997 • 926 citations

Matrix Metalloproteinase-2 Is an Interstitial Collagenase

1995 • 917 citations

Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts*1

1988 • 887 citations

A specific immunoassay for monitoring human bone resorption: Quantitation of type I collagen cross-linked N-telopeptides in urine

1992 • 667 citations

Proteolytic Activity of Human Osteoclast Cathepsin K

1996 • 494 citations

Human Cathepsin O2, a Matrix Protein-degrading Cysteine Protease Expressed in Osteoclasts

1996 • 427 citations

Cellular Biology and Biochemical Mechanism of Bone Resorption

1988 • 383 citations

Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts.

1994 • 340 citations

Immunoassay for quantifying type I collagen degradation products in urine evaluated

1994 • 331 citations

Localization of matrix metalloproteinase 9 (92-kilodalton gelatinase/type IV collagenase = gelatinase B) in osteoclasts: implications for bone resorption.

1995 • 312 citations

Biology and Physiology of the Osteoclast

1992 • 297 citations

Degradation of collagen in the bone‐resorbing compartment underlying the osteoclast involves both cysteine‐proteinases and matrix metalloproteinases

1992 • 286 citations

Action of rat liver cathepsin L on collagen and other substrates.

1982 • 221 citations

Localization of cathepsin K in human osteoclasts by in situ hybridization and immunohistochemistry

1997 • 194 citations

Identification of matrix metalloproteinase 9 in rabbit osteoclasts.

1994 • 169 citations

A comparison of four cathepsins (B, L, N and S) with collagenolytic activity from rabbit spleen

1988 • 158 citations

Cathepsin K Antisense Oligodeoxynucleotide Inhibits Osteoclastic Bone Resorption

1997 • 155 citations

Measurement of Bone Degradation Products in Serum Using Antibodies Reactive with an Isomerized Form of an 8 Amino Acid Sequence of the C-Telopeptide of Type I Collagen

1997 • 135 citations

The determination of total hydroxyproline in urine and bone extracts

1966 • 128 citations

Inhibition of bone resorption in culture by inhibitors of thiol proteinases

1980 • 120 citations

Cleavage of native type I collagen by human neutrophil elastase

1998 • 105 citations

Retinoic acid directly stimulates osteoclastic bone resorption and gene expression of cathepsin K/OC-2

1995 • 103 citations

Limited proteolysis of type I collagen at hyperreactive sites by class I and II Clostridium histolyticum collagenases: complementary digestion patterns

1987 • 102 citations

A new synthetic inhibitor of mammalian tissue collagenase inhibits bone resorption in culture

1985 • 98 citations

Mammalian Mature Osteoclasts as Estrogen Target Cells

1996 • 93 citations

[6] Active-site titration of peptidases

1995 • 81 citations

Identification ofClostridium histolyticum collagenase hyperreactive sites in type I, II, and III collagens: Lack of correlation with local triple helical stability

1992 • 66 citations

Collagenolytic Cathepsins of Rabbit Spleen: A Kinetic Analysis of Collagen Degradation and Inhibition by Chicken Cystatin

1987 • 59 citations

The Dissolution of Insoluble Bovine Collagens by Cathepsin BI, Collagenolytic Cathepsin and Pepsin: The influence of collagen type, age and chemical purity on susceptibility

1977 • 50 citations

Age-related thermal stability and susceptibility to proteolysis of rat bone collagen

1990 • 47 citations

Differences in the degradation of native collagen by two microbial collagenases

1979 • 47 citations

The Influence of Dissolved Calcium Salts on the Degradation of Hard-Tissue Collagens by Lysosomal Cathepsins

1987 • 36 citations

Concanavalin A Directly Stimulates Bone-Resorbing Activity of Osteoclasts and Their Gene Expression of Cathepsin K/OC-2

1997 • 11 citations