RNAi Related Mechanisms Affect Both Transcriptional and Posttranscriptional Transgene Silencing in Drosophila

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

Identification of Novel Genes Coding for Small Expressed RNAs

2001 • 4,834 citations

Role for a bidentate ribonuclease in the initiation step of RNA interference

2001 • 4,804 citations

RNA interference is mediated by 21- and 22-nucleotide RNAs

2001 • 3,271 citations

An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans

2001 • 3,225 citations

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

2000 • 2,945 citations

An Extensive Class of Small RNAs in Caenorhabditis elegans

2001 • 2,806 citations

A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA

2001 • 2,623 citations

RNAi

2000 • 2,596 citations

Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing

2001 • 1,847 citations

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

2001 • 1,761 citations

Argonaute2, a Link Between Genetic and Biochemical Analyses of RNAi

2001 • 1,492 citations

The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans

1999 • 1,286 citations

Use of dsRNA-Mediated Genetic Interference to Demonstrate that frizzled and frizzled 2 Act in the Wingless Pathway

1998 • 1,116 citations

Arabidopsis SGS2 and SGS3 Genes Are Required for Posttranscriptional Gene Silencing and Natural Virus Resistance

2000 • 1,082 citations

An RNA-Dependent RNA Polymerase Gene in Arabidopsis Is Required for Posttranscriptional Gene Silencing Mediated by a Transgene but Not by a Virus

2000 • 1,061 citations

A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal

1998 • 955 citations

RNA-directed de novo methylation of genomic sequences in plants

1994 • 929 citations

Transcriptional silencing and promoter methylation triggered by double-stranded RNA

2000 • 866 citations

Targeted mRNA degradation by double-stranded RNA in vitro

1999 • 845 citations

A Similarity Between Viral Defense and Gene Silencing in Plants

1997 • 821 citations

mut-7 of C. elegans, Required for Transposon Silencing and RNA Interference, Is a Homolog of Werner Syndrome Helicase and RNaseD

1999 • 745 citations

Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline

2001 • 745 citations

Systemic Spread of Sequence-Specific Transgene RNA Degradation in Plants Is Initiated by Localized Introduction of Ectopic Promoterless DNA

1998 • 694 citations

AGO1 defines a novel locus of Arabidopsis controlling leaf development

1998 • 657 citations

Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase

1999 • 653 citations

RNA-triggered gene silencing

1999 • 623 citations

Smart single-chip gas sensor microsystem

2001 • 598 citations

RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans

1998 • 561 citations

AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals

2000 • 555 citations

Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology.

1991 • 504 citations

RNA–DNA Interactions and DNA Methylation in Post-Transcriptional Gene Silencing

1999 • 452 citations

Domains in gene silencing and cell differentiation proteins: the novel PAZ domain and redefinition of the Piwi domain

2000 • 426 citations

Double-Stranded RNA as a Template for Gene Silencing

2000 • 421 citations

Transgene silencing of the al-1 gene in vegetative cells of Neurospora is mediated by a cytoplasmic effector and does not depend on DNA-DNA interactions or DNA methylation.

1996 • 373 citations

RNAi as Random Degradative PCR

2001 • 370 citations

SDE3 encodes an RNA helicase required for post-transcriptional gene silencing in Arabidopsis

2001 • 365 citations

RNA-directed transcriptional gene silencing in plants can be inherited independently of the RNA trigger and requires Met1 for maintenance

2001 • 363 citations

Isolation of quelling-defective ( qde ) mutants impaired in posttranscriptional transgene-induced gene silencing in Neurospora crassa

1997 • 307 citations

Transgene‐mediated suppression of chalcone synthase expression in Petunia hybrida results from an increase in RNA turnover

1994 • 297 citations

Gene silencing mediated by promoter homology occurs at the level of transcription and results in meiotically heritable alterations in methylation and gene activity

1996 • 286 citations

Transcriptional and posttranscriptional gene silencing are mechanistically related

2001 • 266 citations

Post-transcriptional regulation contributes to Drosophila clock gene mRNA cycling

1997 • 257 citations

Posttranscriptional Gene Silencing in Neurospora by a RecQ DNA Helicase

1999 • 252 citations

Cosuppression in Drosophila: Gene Silencing of Alcohol dehydrogenase by white-Adh Transgenes Is Polycomb Dependent

1997 • 245 citations

Evidence that processed small dsRNAs may mediate sequence-specific mRNA degradation during RNAi in Drosophila embryos

2000 • 239 citations

DNA methylation and chromatin structure affect transcriptional and post-transcriptional transgene silencing in Arabidopsis

2000 • 238 citations

Production of aberrant promoter transcripts contributes to methylation and silencing of unlinked homologous promoters in trans

1999 • 228 citations

The DNA methylation locusDDM1 is required for maintenance of gene silencing in Arabidopsis

1998 • 223 citations

Taming of transposable elements by homology-dependent gene silencing

1999 • 221 citations

RNA-based silencing strategies in plants

2001 • 212 citations

De novomethylation and co-suppression induced by a cytoplasmically replicating plant RNA virus

1998 • 195 citations

aubergine enhances oskar translation in the Drosophila ovary

1996 • 164 citations

Release of epigenetic gene silencing by trans-acting mutations in Arabidopsis

1998 • 157 citations

Transgene-mediated cosuppression in the C. elegans germ line

2000 • 157 citations

Genetic and Molecular Characterization of sting, a Gene Involved in Crystal Formation and Meiotic Drive in the Male Germ Line of Drosophila melanogaster

1999 • 152 citations

Distinct roles for RDE-1 and RDE-4 during RNA interference in Caenorhabditis elegans.

2001 • 151 citations

Role of transcriptional interference in the Drosophila melanogaster Adh promoter switch

1989 • 138 citations

Developmental roles and molecular characterization of a Drosophila homologue of Arabidopsis Argonaute1, the founder of a novel gene superfamily

2001 • 123 citations

A DNA target of 30 bp is sufficient for RNA-directed DNA methylation

2000 • 115 citations

Replicating satellite RNA induces sequence-specific DNA methylation and truncated transcripts in plants

2001 • 97 citations

Cosuppression of Nonhomologous Transgenes in Drosophila Involves Mutually Related Endogenous Sequences

1999 • 88 citations

Use of P-Element-Mediated Transformation to Identify the Molecular Basis of Naturally Occurring Variants Affecting Adh Expression in Drosophila melanogaster

1987 • 81 citations

Making noise about silence: repression of repeated genes in animals

2000 • 79 citations

Deletions at intervening sequence splice sites in the alcohol dehydrogenase gene ofDrosophila

1982 • 70 citations

Molecular cloning and characterization of a rabbit eIF2C protein

1998 • 69 citations

Copy number control of a transposable element, the I factor, a LINE-like element in Drosophila

1998 • 53 citations

Transcriptional and Posttranscriptional Silencing of Rodent α1(I) Collagen by a Homologous Transcriptionally Self-Silenced Transgene

1999 • 50 citations

Natural mRNA is required for directing Met-tRNAf binding to 40S ribosomal subunits in animal cells: involvement of Co-eIF-2A in natural mRNA-directed initiation complex formation

1988 • 34 citations

Posttranscriptional reporter transgene silencing in transgenic tobacco

1996 • 12 citations