Post-transcriptional Regulation of Thyroid Hormone Receptor Expression by cis-Acting Sequences and a Naturally Occurring Antisense RNA

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Current protocols in molecular biology

1988 • 7,584 citations

Thyroid Hormone Receptors: Multiple Forms, Multiple Possibilities*

1993 • 1,009 citations

Evolution of the nuclear receptor gene superfamily.

1992 • 662 citations

Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: Identification of an upstream control region

1981 • 646 citations

Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1

1998 • 503 citations

The E75 ecdysone-inducible gene responsible for the 75B early puff in Drosophila encodes two new members of the steroid receptor superfamily.

1990 • 483 citations

Tissue Differences in the Concentration of Triiodothyronine Nuclear Binding Sites in the Rat: Liver, Kidney, Pituitary, Heart, Brain, Spleen and Testis

1974 • 469 citations

Regulation of Translation in Eukaryotic Systems

1992 • 467 citations

Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing

1989 • 437 citations

Thyroid hormone receptor α isoforms generated by alternative splicing differentially activate myosin HC gene transcription

1988 • 425 citations

A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit.

1989 • 316 citations

Antisense RNA: Function and Fate of Duplex RNA in Cells of Higher Eukaryotes

1998 • 314 citations

Alternative splicing generates messages encoding rat c-erbA proteins that do not bind thyroid hormone.

1988 • 300 citations

Relationship of c-erbA mRNA content to tissue triiodothyronine nuclear binding capacity and function in developing and adult rats.

1990 • 298 citations

Inhibition by SR proteins of splicing of a regulated adenovirus pre-mRNA

1996 • 258 citations

Identification of a Rat c-erbAα-Related Protein Which Binds Deoxyribonucleic Acid but does not Bind Thyroid Hormone

1988 • 254 citations

Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus

1989 • 251 citations

Stoichiometric and steric principles governing repression by nuclear hormone receptors.

1997 • 236 citations

Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor.

1988 • 225 citations

Polypurine sequences within a downstream exon function as a splicing enhancer.

1994 • 222 citations

G Triplets Located throughout a Class of Small Vertebrate Introns Enforce Intron Borders and Regulate Splice Site Selection

1997 • 220 citations

The Monomer-Binding Orphan Receptor Rev-Erb Represses Transcription as a Dimer on a Novel Direct Repeat

1995 • 204 citations

Induction of Rev-ErbA alpha, an orphan receptor encoded on the opposite strand of the alpha-thyroid hormone receptor gene, during adipocyte differentiation

1993 • 199 citations

The Cardiac troponin T Alternative Exon Contains a Novel Purine-Rich Positive Splicing Element

1993 • 189 citations

Inhibition of c-erbA mRNA splicing by a naturally occurring antisense RNA.

1991 • 184 citations

Structural Elements of an Orphan Nuclear Receptor–DNA Complex

1998 • 151 citations

Common themes in the function of transcription and splicing enhancers

1997 • 151 citations

Human carboxyl-terminal variant of alpha-type c-erbA inhibits trans-activation by thyroid hormone receptors without binding thyroid hormone.

1989 • 129 citations

Dominant negative activity of an endogenous thyroid hormone receptor variant (alpha 2) is due to competition for binding sites on target genes.

1993 • 118 citations

Expression of the thyroid hormone receptor gene, erbA , in B lymphocytes: Alternative mRNA processing is independent of differentiation but correlates with antisense RNA levels

1997 • 108 citations

A 32-Nucleotide Exon-Splicing Enhancer Regulates Usage of Competing 5′ Splice Sites in a Differential Internal Exon

1995 • 93 citations

Identification of Intron and Exon Sequences Involved in Alternative Splicing of Insulin Receptor Pre-mRNA

1998 • 82 citations

Characterization of Rous sarcoma virus intronic sequences that negatively regulate splicing

1991 • 79 citations

Gene expression from the c-erbA alpha/Rev-ErbA alpha genomic locus. Potential regulation of alternative splicing by opposite strand transcription.

1990 • 71 citations

Effects of Varying the Position of Thyroid Hormone Response Elements within the Rat Growth Hormone Promoter: Implications for Positive and Negative Regulation by 3,5,3′-Triiodothyronine

1991 • 68 citations

Thyroid hormone action 1994: the plot thickens

1994 • 64 citations

The Thyroid Hormone Receptor Variant α2 Is a Weak Antagonist because It Is Deficient in Interactions with Nuclear Receptor Corepressors*

1998 • 57 citations

Thyroid Hormone Receptor Variant α2

1996 • 51 citations

Isolation of a cDNA Encoding Human Rev-ErbAα: Transcription from the Noncoding DNA Strand of a Thyroid Hormone Receptor Gene Results in a Related Protein That Does Not Bind Thyroid Hormone

1990 • 42 citations

A Short Sequence within Two Purine-Rich Enhancers Determines 5′ Splice Site Specificity

1998 • 40 citations

The dominant negative effect of thyroid hormone receptor splicing variant alpha 2 does not require binding to a thyroid response element.

1995 • 39 citations

The unique C-termini of the thyroid hormone receptor variant, c-erbA alpha 2, and thyroid hormone receptor alpha 1 mediate different DNA-binding and heterodimerization properties.

1992 • 39 citations

Thyroid hormone responsiveness is developmentally regulated in the rat small intestine: a possible role for the alpha-2 receptor variant.

1994 • 34 citations

Developmental expression of mRNAs from a rat C-erbA genomic locus

1992 • 17 citations